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The disc diffusion method and the minimum inhibitory concentration value determination (MIC) were used for antimicrobial activity. QANB demonstrated broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. However, it has effectively shown activity against E. aerogenes, which causes pneumonia, sepsis, urinary tract infections, and wound infections. QANB also showed significant activity against C. albicans. The fact that QANB is much more effective against C. albicans than nystatin, which is widely used as an antifungal drug, supports the idea that this compound can be used as a potential antifungal drug.","id":1334262,"keywords":["Candida Albicans","antifungal activity","azo dyes","Quinolone","pyranoquinolone","actibacterial activity"],"language":"ENG","title":"Synthesis of New Azoquinolone: Evaluation of Structural, Spectral Properties, and Antimicrobial Activity"}],"accessType":"OPEN","attachments":null,"authors":[{"authorId":883797,"duty":"AUTHOR","inPublicationName":"Mehtap Yakut","institution":{"city":["ANKARA"],"code":["NTA5Njgx"],"country":[""],"fullTitle":["ANKARA ÜNİVERSİTESİ \u003e FEN FAKÜLTESİ \u003e KİMYA BÖLÜMÜ"],"rootCode":["NDA0MDA4"],"rootTitle":["ANKARA ÜNİVERSİTESİ"],"status":["KAMU"],"title":["KİMYA BÖLÜMÜ"],"type":[""]},"institutionName":["Ankara Üniversitesi, Fen Fakültesi Kimya Bölümü, Ankara, Türkiye"],"isVerified":false,"name":"Mehtap Özgür (nee Yakut)","orcid":"0000-0002-6237-8522","order":2,"relationId":3500196,"userId":""},{"authorId":1092340,"duty":"AUTHOR","inPublicationName":"Ayşe Gül Caniklioğlu","institution":{"city":["GİRESUN"],"code":["NjA3Nzkw"],"country":[""],"fullTitle":["GİRESUN ÜNİVERSİTESİ \u003e EĞİTİM FAKÜLTESİ \u003e İLKÖĞRETİM BÖLÜMÜ"],"rootCode":["MzU4NDMy"],"rootTitle":["GİRESUN ÜNİVERSİTESİ"],"status":["KAMU"],"title":["İLKÖĞRETİM BÖLÜMÜ"],"type":[""]},"institutionName":["Giresun Üniversitesi, Eğitim Fakültesi, İlköğretim Bölümü, İlköğretim Öğretmenliği Yetiştirme Anabilim Dalı, Giresun, Türkiye"],"isVerified":false,"name":"Ayşe Gül Caniklioğlu","orcid":"0000-0003-0043-6624","order":3,"relationId":3500197,"userId":""},{"authorId":1128393,"duty":"AUTHOR","inPublicationName":"Öznur Ölmez Nalcıoğlu","institution":{"city":["GİRESUN"],"code":["MzMyNDMy"],"country":[""],"fullTitle":["GİRESUN ÜNİVERSİTESİ \u003e EĞİTİM FAKÜLTESİ"],"rootCode":["MzU4NDMy"],"rootTitle":["GİRESUN ÜNİVERSİTESİ"],"status":["KAMU"],"title":["EĞİTİM FAKÜLTESİ"],"type":[""]},"institutionName":["Giresun Üniversitesi Eğitim Fakültesi, Matematik ve Fen Eğitimi Bölümü, Fen Eğitimi Anabilim Dalı, Giresun, Türkiye"],"isVerified":false,"name":"Oznur Olmez Nalcıoğlu","orcid":"0000-0002-9813-1572","order":1,"relationId":3500195,"userId":""}],"citedReferences":null,"createdBy":"f0487b17-60dd-4158-9083-7f874073a3c5","databases":["SCIENCE"],"docType":"PAPER","doi":"10.18596/jotcsa.1719222","downloadCount":1,"endDate":null,"endPage":"206","facetAuthorCity":["ANKARA","GİRESUN"],"facetAuthorCountry":[""],"facetAuthorInstitution":["ANKARA ÜNİVERSİTESİ","GİRESUN ÜNİVERSİTESİ"],"firstIndexDate":"2025-12-31T12:39:39.129773Z","id":1364360,"indexDate":"2026-04-04T20:06:07.73094Z","indexedBy":"indexer","issue":{"id":91810,"isSpecial":false,"month":["11"],"number":"4","publishDate":"2025-12-01T00:00:00","volume":"12","year":"2025"},"journal":{"eissn":"2149-0120","id":"1053","issn":"","name":"Journal of the Turkish Chemical Society, Section A: Chemistry"},"language":"ENG","orderCitationCount":0,"orderTitle":"Synthesisof New Azoquinolone: Evaluation of Structural, Spectral Properties, and Antimicrobial Activity","otherCitations":[{"count":0,"origin":"CrossRef"},{"count":0,"origin":"OpenAlex"},{"count":0,"origin":"OpenCitations"}],"pdf":"56fc9590-e8c5-4197-b7e8-9c509fcdea32","projectGroup":null,"projectnumber":null,"publicationProduct":null,"publicationType":"RESEARCH","publicationYear":2025,"references":[{"authors":null,"context":"1. 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Moradi Rufchahi EO, Pouramir H, Yazdanbakhsh MR, Yousefi H, Bagheri M, Rassa M. Novel azo dyes derived from 8-methyl-4-hydroxyl-2-quinolone: Synthesis, UV–vis studies and biological activity. Chinese Chem Lett [Internet]. 2013 May;24(5):425– 8. Available from: \u003cURL\u003e.","id":25443139,"journalCode":"","order":47,"targetPublication":0,"year":""}],"retreat":false,"startPage":"197","startedDate":null,"subjects":[{"autoLabel":true,"fullName":"Fen \u003e Temel Bilimler \u003e Kimya, Organik","id":112,"name":"Kimya, Organik","rootId":1,"rootName":"Fen"},{"autoLabel":true,"fullName":"Fen \u003e Tıp \u003e Mikrobiyoloji","id":135,"name":"Mikrobiyoloji","rootId":1,"rootName":"Fen"}],"viewCount":23}}],"max_score":11.96984,"total":{"relation":"eq","value":1}},"timed_out":false,"took":4,"trdizinAddress":"https://search.trdizin.gov.tr/tr/yayin/detay/1364360/Synthesis-of-New-Azoquinolone:-Evaluation-of-Structural,-Spectral-Properties,-and-Antimicrobial-Activity"}