{"_shards":{"failed":0,"skipped":0,"successful":3,"total":3},"hits":{"hits":[{"_id":"174971","_index":"publication","_score":12.06848,"_source":{"abstracts":[{"abstract":"Amaç: Herpes simpleks ensefaliti çocuklarda sporadik ensefalitlerin en sık görülen nedenlerinden biridir ve yüksek morbidite ve mortaliteoranına sahiptir. Bu çalışmada çocuklarda klinik ve nörogörüntüleme bulgularıyla tedavi sonuçlarının değerlendirilerek herpes simpleksensefalitinin klinik spektrumunun belirlenmesi amaçlanmıştır.Gereç ve Yöntem: Selçuk Üniversitesi, Çocuk Nöroloji kliniğinde 2005-2010 yılları arasında herpes simpleks ensefaliti tanısı ile izlenen 14hastanın klinik, laboratuvar ve görüntüleme bulguları geriye yönelik olarak değerlendirildi.Bulgular: Serimiz rekürrens gösteren 1 olgu da dahil olmak üzere 14 hastadan oluşuyordu. Olgularımızın ortalama yaşı 3,6 yıl, en sık başvuruşikayetleri ise nöbet ve ateşti. Beyin omurilik sıvısı glukoz konsantrasyonu olguların tümünde normal bulunurken yüksek protein ve eritrositdeğerleri olguların %28'inde tespit edildi. Herpes simpleks virüs polimeraz zincir reaksiyonu olguların %92sinde pozitifti ve kraniyalmanyetik rezonans görüntüleme bulguları olguların tümünde herpes simpleks ensefalitini düşündürmekteydi. 2 yaş altındaki çocuklardabeyin omurilik sıvısı bulguları normal olmasına rağmen talamik tutulum ön plandaydı. 9 olgu sekelsiz iyileşirken 5 olguda kalıcı nörolojiksekel gelişti.Sonuç: Bu bulgular çocuklarda özellikle de 2 yaşın altındaki çocuklarda herpes simpleks ensefaliti tanısının zor olduğunu göstermektedir.Konvulziyon ya da diğer ensefalit bulgularıyla başvuran çocuklarda olası tanılar içerisinde herpes simpleks ensefaliti mutlaka düşünülmeli vekalıcı nörolojik sekelleri önlemek için asiklovir en erken dönemde başlanmalıdır.","id":118048,"keywords":null,"language":"TUR","title":"Clinical Spectrum of the Herpes Simplex Encephalitis in Children: Clinical Features, Neuroimaging, Treatment, and Outcomes"},{"abstract":"Objective: Herpes simplex encephalitis is one of the most common causes of sporadic encephalitis in children and it is associated with highmortality and morbidity. This study aims at describing the clinical spectrum of herpes simplex encephalitis in children by identifying theirneurological imaging features and assessing potential treatment outcomes.Methods: Clinical, laboratory, and imaging findings in 14 patients with herpes simplex encephalitis were retrospectively reviewed duringthe period between January 2005 and January 2010 at Selcuk University, Department of Pediatric Neurology.Results: Our study consisted of 14 patients including a patient who had a relapsing course. The median age of the patients was 3,6 years.Seizure and fever were the most common findings at admission. Cerebrospinal fluid glucose concentration was normal in all patients.Protein and red blood cell levels were elevated in 28% patients. Polymerase chain reaction testing for HSV was positive in 92% and cranialmagnetic resonance imaging was suggestive of herpes simplex encaphalitis in all the patients. Prominent thalamic involvement wasobserved in patients less than 2 years of age, however cerebrospinal fluid findings in these patients were normal. 9 patients were left withno neurological sequelae however persistent neurological sequelae was present in 5 patients.Conclusion: The findings suggested how challenging it could get to diagnose herpes encephalitis in children, especially those under theage of 2. Due to its diagnostic possibility in children presenting with convulsion and other encephalitic processes, treatment with acyclovirmust be initiated as soon as herpes encephalitis is suspected to avoid further neurological insults.","id":221034,"keywords":null,"language":"ENG","title":"Çocuklarda Herpes Simpleks Ensefalitinin Klinik Spektrumu: Klinik Bulgular, Nörogörüntüleme, Tedavi ve Sonuçlarının Değerlendirilmesi"}],"accessType":"OPEN","attachments":null,"authors":[{"authorId":899788,"duty":"AUTHOR","inPublicationName":"Kürşad AYDIN","institution":{"city":["ANKARA"],"code":["MzYzODU4"],"country":["Türkiye"],"fullTitle":["GAZİ ÜNİVERSİTESİ \u003e TIP FAKÜLTESİ \u003e DAHİLİ TIP BİLİMLERİ BÖLÜMÜ \u003e NÖROLOJİ ANABİLİM DALI"],"rootCode":["NDAwOTUw"],"rootTitle":["GAZİ ÜNİVERSİTESİ"],"status":["KAMU"],"title":["NÖROLOJİ ANABİLİM DALI"],"type":[""]},"institutionName":["Gazi Üniversitesi, Tıp Fakültesi, Pediatrik Nöroloji Anabilim Dalı, Ankara, Türkiye"],"isVerified":false,"name":"KÜRSAD AYDIN","orcid":"0000-0003-1513-6149","order":2,"relationId":1234649,"userId":""},{"authorId":925399,"duty":"AUTHOR","inPublicationName":"Ayşe KARTAL","institution":{"city":["MALATYA"],"code":["MzcwODM0"],"country":["Türkiye"],"fullTitle":["İNÖNÜ ÜNİVERSİTESİ \u003e TIP FAKÜLTESİ \u003e DAHİLİ TIP BİLİMLERİ BÖLÜMÜ \u003e NÖROLOJİ ANABİLİM DALI"],"rootCode":["Mzk5NDk3"],"rootTitle":["İNÖNÜ ÜNİVERSİTESİ"],"status":["KAMU"],"title":["NÖROLOJİ ANABİLİM DALI"],"type":[""]},"institutionName":["İnönü Üniversitesi Tıp Fakültesi, Pediatrik Nöroloji Anabilim Dalı, Malatya, Türkiye"],"isVerified":false,"name":"Ayşe Kartal","orcid":"0000-0002-7775-8747","order":1,"relationId":1234648,"userId":""}],"citedReferences":null,"createdBy":"system","databases":["SCIENCE"],"docType":"PAPER","doi":null,"downloadCount":0,"endDate":null,"endPage":"93","facetAuthorCity":["ANKARA","MALATYA"],"facetAuthorCountry":["Türkiye"],"facetAuthorInstitution":["GAZİ ÜNİVERSİTESİ","İNÖNÜ ÜNİVERSİTESİ"],"firstIndexDate":"2022-07-29T23:04:47.244556Z","id":174971,"indexDate":"2026-05-25T15:35:20.31302Z","indexedBy":"indexer","issue":{"id":35268,"isSpecial":false,"month":["6"],"number":"2","publishDate":"2015-06-01T00:00:00","volume":"22","year":"2015"},"journal":{"eissn":"","id":"148","issn":"1300-1744","name":"İnönü Üniversitesi Turgut Özal Tıp Merkezi Dergisi"},"language":"TUR","orderCitationCount":0,"orderTitle":"ClinicalSpectrum of the Herpes Simplex Encephalitis in Children: Clinical Features, Neuroimaging, Treatment, and Outcomes","otherCitations":null,"pdf":"80ba7e68-b284-4ef9-a012-7fcd2250e4ef","projectGroup":null,"projectnumber":null,"publicationProduct":null,"publicationType":"RESEARCH","publicationYear":2015,"references":[{"authors":null,"context":"1. Granerod J, Ambrose HE, Davies NW, Clewley JP, Walsh  AL, Morgan D, et al. Causes of encephalitis and differences  in their clinical presentations in England: a multicentre,  population-based prospective study. Lancet Infect Dis  2010;10:835-44.","id":3268528,"journalCode":"","order":1,"targetPublication":0,"year":""},{"authors":null,"context":"2. Whitley RJ, Kimberlin DW. Herpes simplex encephalitis:  children and adolescents. Semin Pediatr Infect Dis  2005;16:17-23.","id":3268529,"journalCode":"","order":2,"targetPublication":0,"year":""},{"authors":null,"context":"3. De Tie`ge X, Heron B, Lebon P, Ponsot G, Rozenberg F.  Limits of early diagnosis of herpes simplex encephalitis in  children: a retrospective study of 38 cases. Clin Infect Dis  2003;36:1335-39.","id":3268530,"journalCode":"","order":3,"targetPublication":0,"year":""},{"authors":null,"context":"4. Lakeman FD, Whitley RJ. Diagnosis of herpes simplex  encephalitis: application of polymerase chain reaction to  cerebrospinal fluid from brain-biopsied patients and  correlation with disease: National Institute of Allergy and  Infectious Diseases Collaborative Antiviral Study Group. J  Infect Dis 1995;171:857-63.","id":3268531,"journalCode":"","order":4,"targetPublication":0,"year":""},{"authors":null,"context":"5. Kennedy PG, Chaudhuri A. Herpes simplex encephalitis. J  Neurol Neurosurg Psychiatry 2002;73:237-38.","id":3268527,"journalCode":"","order":5,"targetPublication":0,"year":""},{"authors":null,"context":"6. Leonard JR, Moran CJ, Cross 3rd DT, Wippold 2nd FJ,  Schlesinger Y, Storch GA. MR imaging of herpes simplex  type 1 encephalitis in infants and young children: a separate  pattern of findings. AJR Am J Roentgenol 2000;174:1651-55.","id":3268532,"journalCode":"","order":6,"targetPublication":0,"year":""},{"authors":null,"context":"7. Whitley RJ. Herpes simplex encephalitis: adolescents and  adults. Antiviral Res 2006;71:141-48.","id":3268533,"journalCode":"","order":7,"targetPublication":0,"year":""},{"authors":null,"context":"8. Lahat E, Barr J, Barkai G, Paret G, Brand N, Barzilai A. Long  term neurological outcome of herpes encephalitis. Arch Dis  Child. 1999;80:69-71.","id":3268534,"journalCode":"","order":8,"targetPublication":0,"year":""},{"authors":null,"context":"9. McGrath N, Anderson NE, Croxson MC, Powell KF. Herpes  simplex encephalitis treated with acyclovir: diagnosis and  long term outcome. J Neurol Neurosurg Psychiatry.  1997;63:321-26.","id":3268535,"journalCode":"","order":9,"targetPublication":0,"year":""},{"authors":null,"context":"10. Elbers JM, Bitnun A, Richardson SE, Ford-Jones EL, Tellier  R, Wald RM, et al. A 12-year prospective study of childhood  herpes simplex encephalitis: is there a broader spectrum of  disease? Pediatrics 2007;119:399-407.","id":3268536,"journalCode":"","order":10,"targetPublication":0,"year":""},{"authors":null,"context":"11. Whitley RJ, Soong SJ, Linneman Jr C, Liu C, Pazin G, Alford  CA. Herpes simplex encephalitis. Clinical Assessment JAMA  1982;247:317-20.","id":3268537,"journalCode":"","order":11,"targetPublication":0,"year":""},{"authors":null,"context":"12. Raschilas F, Wolff M, Delatour F, Chaffaut C, De Broucker T,  Chevret S, et al. Outcome of and prognostic factors for  herpes simplex encephalitis in adult patients: results of a  multicenter study. Clin Infect Dis 2002;35:254-60.","id":3268538,"journalCode":"","order":12,"targetPublication":0,"year":""},{"authors":null,"context":"13. Uren EC, Johnson PD, Montanaro J, Gilbert GL. Herpes  simplex virus encephalitis in pediatrics: diagnosis by  detection of antibodies and DNA in cerebrospinal fluid.  Pediatr Infect Dis J 1993;12:10016.","id":3268539,"journalCode":"","order":13,"targetPublication":0,"year":""},{"authors":null,"context":"14. Weil AA, Glaser CA, Amad Z, Forghani B. Patients with  suspected herpes simplex encephalitis: rethinking an initial  negative polymerase chain reaction result. Clin Infect Dis  2002;34:1154-7.","id":3268540,"journalCode":"","order":14,"targetPublication":0,"year":""},{"authors":null,"context":"15. Maschke M, Kastrup O, Forsting M, Diener HC. Update on  neuroimaging in infectious central nervous system disease.  Curr Opin Neurol 2004;17:475–80.","id":3268541,"journalCode":"","order":15,"targetPublication":0,"year":""},{"authors":null,"context":"16. De Tie`ge X, Rozenberg F, Des Portes V, Lobut JB, Lebon P,  Ponsot G, et al. Herpes simplex encephalitis relapses in  children: differentiation of two neurologic entities.  Neurology 2003;61:241-3.","id":3268542,"journalCode":"","order":16,"targetPublication":0,"year":""},{"authors":null,"context":"17. De Tie`ge X, Rozenberg F, Burlot K, Gaudelus J, Ponsot G,  Heron B. Herpes simplex encephalitis: diagnostic problems  and late relapse. Dev Med Child Neurol 2006;48:60-3.","id":3268543,"journalCode":"","order":17,"targetPublication":0,"year":""},{"authors":null,"context":"18. Panisset S, Adamasbaum C, Heron B, Panisset S,  Adamsbaum C, Heron B, et al. Imaging in pediatric herpes  simplex virus type I encephalitis. J Radiol 1999;80:31-5.","id":3268544,"journalCode":"","order":18,"targetPublication":0,"year":""},{"authors":null,"context":"19. Wasay M, Mekan SF, Khelaeni B, Saeed Z, Hassan A,  Cheema Z, et al. Extra temporal involvement in herpes  simplex encephalitis. Eur J Neurol 2005;12:475-9.","id":3268545,"journalCode":"","order":19,"targetPublication":0,"year":""},{"authors":null,"context":"20. Lai CW, Gragasin ME. Electroencephalography in herpes  simplex encephalitis. J Clin Neurophysiol 1988;5:87-103.","id":3268546,"journalCode":"","order":20,"targetPublication":0,"year":""},{"authors":null,"context":"21. Brick JF, Brick JE, Morgan JJ, Gutierrez AR. EEG and  pathologic findings in patients undergoing brain biopsy for  suspected encephalitis. Electroencephalogr Clin  Neurophysiol 1990;76:86-9.","id":3268547,"journalCode":"","order":21,"targetPublication":0,"year":""},{"authors":null,"context":"22. Schleede L, Bueter W, Baumgartner-Sigl S, Opladen T,  Weigt-Usinger K, Stephan S, et al. Pediatric herpes simplex  virus encephalitis: a retrospective multicenter experience. J  Child Neurol 2013;28:321-31.","id":3268549,"journalCode":"","order":22,"targetPublication":0,"year":""},{"authors":null,"context":"23. Ito Y, Kimura H, Yabuta Y, Ando Y, Murakami T, Shiomi M,  et al. Exacerbation of herpes simplex encephalitis after  successful treatment with acyclovir. Clin Infect Dis  2000;30:185-87.","id":3268584,"journalCode":"","order":23,"targetPublication":0,"year":""}],"retreat":false,"startPage":"90","startedDate":null,"subjects":[{"autoLabel":false,"fullName":"Fen \u003e Tıp \u003e Mikrobiyoloji","id":135,"name":"Mikrobiyoloji","rootId":1,"rootName":"Fen"},{"autoLabel":false,"fullName":"Fen \u003e Tıp \u003e Pediatri","id":163,"name":"Pediatri","rootId":1,"rootName":"Fen"}],"viewCount":4}}],"max_score":12.06848,"total":{"relation":"eq","value":1}},"timed_out":false,"took":2,"trdizinAddress":"https://search.trdizin.gov.tr/tr/yayin/detay/174971/Clinical-Spectrum-of-the-Herpes-Simplex-Encephalitis-in-Children:-Clinical-Features,-Neuroimaging,-Treatment,-and-Outcomes"}