Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis

Erkorkmaz, Ünal; DENİZ DEMİR, HELİN; AYDIN, Erdinç; ÖZYURT, Hüseyin

Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis

Erdinç AYDIN, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Tokat, Türkiye)

Helin Deniz DEMİR, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Tokat, Türkiye)

Hüseyin ÖZYURT, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Tokat, Türkiye)

Ünal ERKORKMAZ (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Tokat, Türkiye)

Turkish Journal of Medical Sciences

3 0

Yıl: 2010 Cilt: 40 Sayı: 4 Sayfa Aralığı: 605 - 612 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis

Öz:

Amaç:% 1 kafeik asit feniletil ester (CAPE), % 0,1 olopatidine hidroklorür ve % 0,1 deksametazon sodyum fosfat’ın anti- alerjik etkinliğinin karşılaştırılması. Yöntem ve gereç: Deneysel alerjik konjonktivit üç gruba ayrılmış 31 Yeni Zelanda tipi tavşanlarda bir mast hücre aktivatörü olan 48/80 bileşik ile oluşturuldu. % 1 CAPE, % 0,1 olopatidine hidroklorür ve % 0,1 deksametazon sodyum fosfat provokasyondan 30 dakika önce, provokasyondan 15 dakika sonra damlatıldı. Her bir grupta çalışma (sağ) ve kontrol (sol) gözlerinde ödem ve hiperemi derecelendirildi. Ön segment fotoğrafları ve histopatolojik değerlendirme için konjunktiva örnekleri alındı ve derecelendirildi. Bulgular: Provokasyon sonrası dönemde ödem ve hiperemi skorları provokasyon dönemi ile karşılaştırıldığında her grupta anlamlı farklılık belirlendi (P = 0,021; P = 0,037; P = 0,0001). provokasyon dönemi ve provokasyon sonrasıdönemde histopatolojik skorlar değerlendirildiğinde, CAPE ve deksametazon sodyum fosfat gruplarında istatistiki anlamlı farklılık bulunurken (P = 0,003; P = 0,014), olopatidine grubunda mevcut değildi (P = 0,096). Sonuç: Bu çalışma % 1 CAPE’nin klinik olarak % 0,1 olopatidine ve % 0,1 deksametazon kadar etkili olduğunu göstermektedir. % 1 CAPE, akut alerjik konjonktivitin kontrol altına alınmasında % 0,1 olopatidine ve % 0,1 deksametazon’a bir alternatif olabilir.

Anahtar Kelime:

Konular: Cerrahi

Deneysel alerjik konjonktivit modelinde kafeik asit feniletil ester (CAPE), olopatadine hidroklorid ve deksametazon sodyum fosfat’ın etkinliklerinin karşılaştırılması

Öz:

Aim: To compare the antiallergic efficacy of 1% caffeic acid phenethyl ester (CAPE), 0.1% olopatadine hydrochloride, and 0.1% dexamethasone sodium phosphate. Materials and methods: Experimental allergic conjunctivitis was provoked by a mast cell activator (compound 48/80) in 31 New Zealand rabbits. The rabbits were divided into 3 groups, and 1% CAPE, 0.1% olopatadine hydrochloride, and 0.1% dexamethasone sodium phosphate were instilled 30 min before and 15 min after the provocation. The edema and hyperemia in the experimental (right) eyes and control (left) eyes were scored in each group. Anterior segment photographs and conjunctival samples for histopathological evaluation and scoring were taken.Results: When the edema and hyperemia scores of the postprovocation term were compared with those of the provocation term, a significant difference was detected in each group (P = 0.021, P = 0.037, P = 0.0001). The histopathological scores of the provocation and postprovocation terms were evaluated; a statistically significant difference was found in the CAPE and dexamethasone sodium phosphate groups (P = 0.003, P = 0.014), but not in the olopatadine group (P = 0.096). Conclusion: This study demonstrated that 1% CAPE was as clinically efficacious as 0.1% olopatadine and 0.1% dexamethasone. Thus, 1% CAPE may be an alternative to 0.1% olopatadine and 0.1% dexamethasone in the management of acute allergic reactions.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	AYDIN E, DENİZ DEMİR H, ÖZYURT H, Erkorkmaz Ü (2010). Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis. , 605 - 612.
Chicago	AYDIN Erdinç,DENİZ DEMİR HELİN,ÖZYURT Hüseyin,Erkorkmaz Ünal Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis. (2010): 605 - 612.
MLA	AYDIN Erdinç,DENİZ DEMİR HELİN,ÖZYURT Hüseyin,Erkorkmaz Ünal Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis. , 2010, ss.605 - 612.
AMA	AYDIN E,DENİZ DEMİR H,ÖZYURT H,Erkorkmaz Ü Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis. . 2010; 605 - 612.
Vancouver	AYDIN E,DENİZ DEMİR H,ÖZYURT H,Erkorkmaz Ü Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis. . 2010; 605 - 612.
IEEE	AYDIN E,DENİZ DEMİR H,ÖZYURT H,Erkorkmaz Ü "Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis." , ss.605 - 612, 2010.
ISNAD	AYDIN, Erdinç vd. "Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis". (2010), 605-612.

APA	AYDIN E, DENİZ DEMİR H, ÖZYURT H, Erkorkmaz Ü (2010). Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis. Turkish Journal of Medical Sciences, 40(4), 605 - 612.
Chicago	AYDIN Erdinç,DENİZ DEMİR HELİN,ÖZYURT Hüseyin,Erkorkmaz Ünal Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis. Turkish Journal of Medical Sciences 40, no.4 (2010): 605 - 612.
MLA	AYDIN Erdinç,DENİZ DEMİR HELİN,ÖZYURT Hüseyin,Erkorkmaz Ünal Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis. Turkish Journal of Medical Sciences, vol.40, no.4, 2010, ss.605 - 612.
AMA	AYDIN E,DENİZ DEMİR H,ÖZYURT H,Erkorkmaz Ü Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis. Turkish Journal of Medical Sciences. 2010; 40(4): 605 - 612.
Vancouver	AYDIN E,DENİZ DEMİR H,ÖZYURT H,Erkorkmaz Ü Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis. Turkish Journal of Medical Sciences. 2010; 40(4): 605 - 612.
IEEE	AYDIN E,DENİZ DEMİR H,ÖZYURT H,Erkorkmaz Ü "Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis." Turkish Journal of Medical Sciences, 40, ss.605 - 612, 2010.
ISNAD	AYDIN, Erdinç vd. "Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis". Turkish Journal of Medical Sciences 40/4 (2010), 605-612.