The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience
Yıl: 2021 Cilt: 11 Sayı: 1 Sayfa Aralığı: 129 - 136 Metin Dili: İngilizce DOI: 10.31832/smj.784990 İndeks Tarihi: 05-12-2022
The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience
Öz: Objective The purpose of this study was to review the general characteristics, risk factors, treatment modalities of our head and neck cancer (HNC) patients and to calculate survival of patients, to evaluate the factors affecting our treatment results and survival. Materials and Methods Sixty-seven eligible patients with HNC were evaluated. The study data were obtained from the files of patients diagnosed with HNC who were followed up in Sakarya University Training and Research Hospital between 2011 and 2020. Results The median age at diagnosis was 62 ± 11.40 (range: 19 to 82), 62 in men and 50 in women. The most common location was larynx with 55% frequency. Cigarette and alcohol use rates were 69% and 18%, respectively. Secondary malignancy was observed in 18% (n = 12) of the patients, with the most common secondary malignancy being lung cancer (9%, n = 6). The stages of the patients at the time of diagnosis were 13.45% (n = 9), 22.47% (n = 15), 50.77% (n = 34) and 11.93% (n = 8) stage 1,2,3 and 4, respectively. Forty two percent of the patients had metastases at the time of diagnosis or metastasis developed during follow-up. Metastatic sites were lung in 13 patients (19.45%), lymph node in 10 patients (15%), bone in 7 patients (10.56%), and liver in 1 (1.50%) patient. Local recurrence occurred in 27% (n = 18) of patients. Local recurrence and / or metastasis developed in 50% of 58 patients with stage 1, 2 or 3. The majority of these patients were stage 3 (n = 17 (59%)). While the median disease free survival (DFS) of stage 1-2 patients was 49 ± 29.65 months (range: 0-107 months), the median DFS of stage 3 patients was calculated as 19 ± 10.95 months (range: 0-40 months). Median Progression-free survival (PFS) after first line chemotherapy (CT) with metastatic HNC cancer was 8±3 months (range: 2-14 months). Median overall survival (OS) was calculated 192±83 months in all patients. Conclusion Secondary malignancy development rates were found to be slightly elevated in our study. The total dose of cisplatin concurrent with RT was slightly lower than the other similar studies. The most preferred combination of chemotherapy in metastatic patients was cisplatin/5Fluorouracil/cetuximab. Our PFS results were slightly higher than in the literature.
Anahtar Kelime: Baş Boyun Kanseri Hastalarının Klinik Özellikleri ve Tedavi Sonuçlarının Değerlendirilmesi: Tek Merkez Deneyimi
Öz: Amaç: Bu çalışmanın amacı baş boyun kanserli (BBK) hastalarımızın genel özelliklerini, risk faktörlerini, tedavi modalitelerini gözden geçirmek ve sağkalımlarını hesaplayıp sağkalımı ve tedavi sonuçlarını etkileyen faktörleri değerlendirmekti. Gereç ve Yöntemler: Altmış yedi BBK tanılı hasta değerlendirildi. Çalışmanın verileri Sakarya Üniversitesi Eğitim ve Araştırma Hastanesinde 2011-2020 yılları arasında takipli hastaların dosyalarından elde edildi. Bulgular: Tanı anındaki medyan yaş erkekler 62, kadınlar 50 olmak üzere tüm hastalarda 62 ± 11,42 (aralık: 19-82) idi. En sık yerleşim yeri %55 oranla larinks idi. Sigara ve alkol kullanım oranları sırasıyla %69 ve %18 idi. Sekonder malignite oranı %18 olup en sık görüleni akciğer kanseriydi (%9, n = 6). Hastaların tanı anındaki evreleri 1,2,3 ve 4 sırasıyla %13,45 (n = 9), %22,47 (n = 15), %50,77(n = 34) ve %11,93 (n = 8) idi. Hastaların tanı anında ya da takibi sırasında olmak üzere toplam %42’si metastatikti. Metastaz bölgeleri 13 hastada (%19,45) akciğer, 10 hastada (%15) lenf nodu, 7 hastada (%10,56) kemik, ve 1 hastada (%1,50) karaciğerdi. Lokal rekürrens %27 (n = 18) oranındaydı. Evre 1,2 ve 3 58 hastanın %50’sinde lokal rekürrens ve/veya metastaz gelişmişti. Bu hastaların çoğunluğu evre 3 hastalardı (n = 17 (%59)). Evre 1-2 hastalarda medyan hastalıksız sağkalım 49 ± 29,65 ay (aralık: 0-107 ay) iken evre 3 hastalarda medyan hastalıksız sağkalım 19 ± 10,95 ay (aralık: 0-40 ay) idi. Metastatik birinci seri kemoterapi sonrası medyan progresyonsuz sağkalım 8±3 ay (aralık: 2-14 ay) ve tüm hastalarda medyan genel sağkalım 192±83 ay idi. Sonuç: Çalışmamızda sekonder malignite gelişme oranı hafif yüksekti. Radyoterapi eş zamanlı sisplatin total dozları literatürdeki benzer diğer çalışmalara göre hafifçe düşüktü. En çok tercih edilen metastatik birinci seri kemoterapi kombinasyonu sisplatin/5Fluorourasil/setuximab’tı. Progresyonsuz sağkalım sonuçları literatüre göre hafif yüksekti.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | DEMİRCİ a, Varım C, bayoglu i, Bilir C, hacibekiroglu i (2021). The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience. , 129 - 136. 10.31832/smj.784990 |
| Chicago | DEMİRCİ ayşe,Varım Ceyhun,bayoglu ibrahim vedat,Bilir Cemil,hacibekiroglu ilhan The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience. (2021): 129 - 136. 10.31832/smj.784990 |
| MLA | DEMİRCİ ayşe,Varım Ceyhun,bayoglu ibrahim vedat,Bilir Cemil,hacibekiroglu ilhan The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience. , 2021, ss.129 - 136. 10.31832/smj.784990 |
| AMA | DEMİRCİ a,Varım C,bayoglu i,Bilir C,hacibekiroglu i The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience. . 2021; 129 - 136. 10.31832/smj.784990 |
| Vancouver | DEMİRCİ a,Varım C,bayoglu i,Bilir C,hacibekiroglu i The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience. . 2021; 129 - 136. 10.31832/smj.784990 |
| IEEE | DEMİRCİ a,Varım C,bayoglu i,Bilir C,hacibekiroglu i "The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience." , ss.129 - 136, 2021. 10.31832/smj.784990 |
| ISNAD | DEMİRCİ, ayşe vd. "The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience". (2021), 129-136. https://doi.org/10.31832/smj.784990 |
| APA | DEMİRCİ a, Varım C, bayoglu i, Bilir C, hacibekiroglu i (2021). The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience. Sakarya Tıp Dergisi, 11(1), 129 - 136. 10.31832/smj.784990 |
| Chicago | DEMİRCİ ayşe,Varım Ceyhun,bayoglu ibrahim vedat,Bilir Cemil,hacibekiroglu ilhan The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience. Sakarya Tıp Dergisi 11, no.1 (2021): 129 - 136. 10.31832/smj.784990 |
| MLA | DEMİRCİ ayşe,Varım Ceyhun,bayoglu ibrahim vedat,Bilir Cemil,hacibekiroglu ilhan The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience. Sakarya Tıp Dergisi, vol.11, no.1, 2021, ss.129 - 136. 10.31832/smj.784990 |
| AMA | DEMİRCİ a,Varım C,bayoglu i,Bilir C,hacibekiroglu i The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience. Sakarya Tıp Dergisi. 2021; 11(1): 129 - 136. 10.31832/smj.784990 |
| Vancouver | DEMİRCİ a,Varım C,bayoglu i,Bilir C,hacibekiroglu i The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience. Sakarya Tıp Dergisi. 2021; 11(1): 129 - 136. 10.31832/smj.784990 |
| IEEE | DEMİRCİ a,Varım C,bayoglu i,Bilir C,hacibekiroglu i "The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience." Sakarya Tıp Dergisi, 11, ss.129 - 136, 2021. 10.31832/smj.784990 |
| ISNAD | DEMİRCİ, ayşe vd. "The Evaluation of Clinical Characteristics and Treatment Results of Head and Neck Cancer Patients: Single Center Experience". Sakarya Tıp Dergisi 11/1 (2021), 129-136. https://doi.org/10.31832/smj.784990 |
