Magnetic resonance imaging findings in COVID-19-related anosmia
Yıl: 2022 Cilt: 52 Sayı: 5 Sayfa Aralığı: 1506 - 1512 Metin Dili: İngilizce DOI: 10.55730/1300-0144.5490 İndeks Tarihi: 27-12-2022
Magnetic resonance imaging findings in COVID-19-related anosmia
Öz: Background/aim: The coronavirus disease 2019 (COVID-19) mostly manifests with fever, shortness of breath, and cough, has also been found to cause some neurological symptoms, such as anosmia and ageusia. The aim of the study was to present the magnetic resonance imaging (MRI) findings of patients with anosmia-hyposmia symptoms and to discuss potential mechanisms in light of these findings. Materials and methods: Of the 2412 patients diagnosed with COVID-19-related pneumonia (RT-PCR at least once + clinically confirmed) between March and December 2020, 15 patients underwent olfactory MRI to investigate the cause of ongoing anosmia/ hyposmia symptoms were included in the study. Results: Eleven (73.3%) patients were female and four (26.7%) were male. A total of eight patients (53.3%) showed thickening in the olfactory cleft region, where the olfactory epithelium is located. In nine patients (60%), enhancement was observed in the olfactory cleft region. Diffusion-weighted imaging showed restricted diffusion in three patients (20%) (corpus callosum splenium in one patient, thalamus mediodorsal nucleus in one patient, and mesencephalon in one patient). Conclusion: This study revealed that there is a relationship between anosmia and MRI findings. Larger studies can enlighten the pathophysiological mechanism and shed light on both diagnosis and new treatments.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Ates OF, Taydas O, Dheir H. Thorax magnetic resonance imaging findings in patients with coronavirus disease (covid-19). Academic Radiology 2020; 27 (10): 1373-1378. doi: 10.1016/j.acra.2020.08.009
- 2. Lüers JC, Klußmann JP, Guntinas-Lichius O. [the covid-19 pandemic and otolaryngology: What it comes down to?]. Laryngo- rhino- otologie 2020; 99 (5): 287-291. doi: 10.1055/a- 1095-2344
- 3. Bagheri SH, Asghari A, Farhadi M, Shamshiri AR, Kabir A et al. Coincidence of covid-19 epidemic and olfactory dysfunction outbreak in Iran. Medical Journal of the Islamic Republic of Iran 2020; 34: 62. doi: 10.34171/mjiri.34.62
- 4. Giacomelli A, Pezzati L, Conti F, Bernacchia D, Siano M et al. Self-reported olfactory and taste disorders in patients with severe acute respiratory coronavirus 2 infection: A cross-sectional study. Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of America 2020; 71 (15): 889-890. doi: 10.1093/cid/ciaa330
- 5. Moein ST, Hashemian SM, Mansourafshar B, Khorram-Tousi A, Tabarsi P et al. Smell dysfunction: A biomarker for covid-19. International Forum of Allergy & Rhinology 2020; 10 (8): 944- 950. doi: 10.1002/alr.22587
- 6. Beltrán-Corbellini Á, Chico-García JL, Martínez-Poles J, Rodríguez-Jorge F, Natera-Villalba E et al. Acute-onset smell and taste disorders in the context of covid-19: A pilot multicentre polymerase chain reaction based case-control study. European Journal of Neurology 2020; 27 (9): 1738-1741. doi: 10.1111/ene.14273
- 7. Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (covid-19): A multicenter european study. European Archives of Oto-rhino-laryngology 2020; 277 (8): 2251-2261. doi: 10.1007/s00405-020-05965-1
- 8. Sungnak W, Huang N, Bécavin C, Berg M, Queen R et al. Sars- cov-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nature Medicine 2020; 26 (5): 681-687. doi: 10.1038/s41591-020-0868-6
- 9. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T et al. Sars-cov-2 cell entry depends on ace2 and tmprss2 and is blocked by a clinically proven protease inhibitor. Cell 2020; 181 (2): 271-280.e278. doi: 10.1016/j.cell.2020.02.052
- 10. Bertram S, Heurich A, Lavender H, Gierer S, Danisch S et al. Influenza and sars-coronavirus activating proteases tmprss2 and hat are expressed at multiple sites in human respiratory and gastrointestinal tracts. PloS one 2012; 7 (4): e35876. doi: 10.1371/journal.pone.0035876
- 11. de Haro-Licer J, Roura-Moreno J, Vizitiu A, González- Fernández A, González-Ares JA. Long term serious olfactory loss in colds and/or flu. Acta Otorrinolaringologica Espanola 2013; 64 (5): 331-338. doi: 10.1016/j.otorri.2013.04.003
- 12. Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S et al. Covid- 19-associated acute hemorrhagic necrotizing encephalopathy: Imaging features. Radiology 2020; 296 (2): E119-e120. doi: 10.1148/radiol.2020201187
- 13. Politi LS, Salsano E, Grimaldi M. Magnetic resonance imaging alteration of the brain in a patient with coronavirus disease 2019 (covid-19) and anosmia. JAMA Neurology 2020; 77 (8): 1028-1029. doi: 10.1001/jamaneurol.2020.2125
- 14. Netland J, Meyerholz DK, Moore S, Cassell M, Perlman S. Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ace2. Journal of Virology 2008; 82 (15): 7264-7275. doi: 10.1128/jvi.00737-08
- 15. Cakir Cetin A, Kumus O, Keskinoglu P, Sutay S, Ecevit MC. Turkish validation of the sino-nasal outcome test-22. Clinical Otolaryngology 2019; 44 (4): 557-564. doi: 10.1111/coa.13332
- 16. Soler ZM, Patel ZM, Turner JH, Holbrook EH. A primer on viral-associated olfactory loss in the era of covid-19. International Forum of Allergy & Rhinology 2020; 10 (7): 814- 820. doi: 10.1002/alr.22578
- 17. Yang X, Yu Y, Xu J, Shu H, Xia J et al. Clinical course and outcomes of critically ill patients with sars-cov-2 pneumonia in wuhan, china: A single-centered, retrospective, observational study. The Lancet Respiratory Medicine 2020; 8 (5): 475-481. doi: 10.1016/s2213-2600(20)30079-5
- 18. Duprez TP, Rombaux P. Imaging the olfactory tract (cranial nerve #1). European Journal of Radiology 2010; 74 (2): 288- 298. doi: 10.1016/j.ejrad.2009.05.065
- 19. Kandemirli SG, Altundag A, Yildirim D, Tekcan Sanli DE, Saatci O. Olfactory bulb mri and paranasal sinus ct findings in persistent covid-19 anosmia. Academic Radiology 2021; 28 (1): 28-35. doi: 10.1016/j.acra.2020.10.006
- 20. Chetrit A, Lechien JR, Ammar A, Chekkoury-Idrissi Y, Distinguin L et al. Magnetic resonance imaging of covid-19 anosmic patients reveals abnormalities of the olfactory bulb: Preliminary prospective study. Journal of Infection 2020; 81 (5): 816-846. doi: 10.1016/j.jinf.2020.07.028
- 21. Strauss SB, Lantos JE, Heier LA, Shatzkes DR, Phillips CD. Olfactory bulb signal abnormality in patients with covid-19 who present with neurologic symptoms. American Journal of Neuroradiology 2020. doi: 10.3174/ajnr.A6751
- 22. Mueller A, Rodewald A, Reden J, Gerber J, von Kummer R et al. Reduced olfactory bulb volume in post-traumatic and post- infectious olfactory dysfunction. Neuroreport 2005; 16 (5): 475-478. doi: 10.1097/00001756-200504040-00011
- 23. Yao L, Yi X, Pinto JM, Yuan X, Guo Y et al. Olfactory cortex and olfactory bulb volume alterations in patients with post- infectious olfactory loss. Brain Imaging and Behavior 2018; 12 (5): 1355-1362. doi: 10.1007/s11682-017-9807-7
- 24. Chung MS, Choi WR, Jeong HY, Lee JH, Kim JH. Mr imaging- based evaluations of olfactory bulb atrophy in patients with olfactory dysfunction. American Journal of Neuroradiology 2018; 39 (3): 532-537. doi: 10.3174/ajnr.A5491
- 25. Özdemir M, Taydaş O, Öztürk MH. Covid-19 enfeksiyonunda toraks bilgisayarlı tomografi bulguları. Journal of Biotechnology and Strategic Health Research 2020; 4: 91-96. doi: 10.34084/ bshr.725584
- 26. Tada H, Takanashi J, Barkovich AJ, Oba H, Maeda M et al. Clinically mild encephalitis/encephalopathy with a reversible splenial lesion. Neurology 2004; 63 (10): 1854-1858. doi: 10.1212/01.wnl.0000144274.12174.cb
- 27. Demopoulos C, Arroyo MS, Dunn W, Strominger Z, Sherr EH et al. Individuals with agenesis of the corpus callosum show sensory processing differences as measured by the sensory profile. Neuropsychology 2015; 29 (5): 751-758. doi: 10.1037/ neu0000165
- 28. Takatsu H, Ishimaru N, Ito M, Kinami S. Mild encephalitis/ encephalopathy with a reversible splenial lesion in an adult patient with influenza. Internal Medicine (Tokyo, Japan) 2017; 56 (22): 3093-3095. doi: 10.2169/internalmedicine.8997-17
- 29. Illig KR. Projections from orbitofrontal cortex to anterior piriform cortex in the rat suggest a role in olfactory information processing. The Journal of Comparative Neurology 2005; 488 (2): 224-231. doi: 10.1002/cne.20595
- 30. Courtiol E, Wilson DA. The olfactory thalamus: Unanswered questions about the role of the mediodorsal thalamic nucleus in olfaction. Frontiers in Neural Circuits 2015; 9: 49. doi: 10.3389/fncir.2015.00049
| APA | ÇETIN H, ATES A, Taydaş O, Elmas B, Guclu E (2022). Magnetic resonance imaging findings in COVID-19-related anosmia. , 1506 - 1512. 10.55730/1300-0144.5490 |
| Chicago | ÇETIN HÜSEYIN,ATES AYSE SULE,Taydaş Ogün,Elmas Bahri,Guclu Ertugrul Magnetic resonance imaging findings in COVID-19-related anosmia. (2022): 1506 - 1512. 10.55730/1300-0144.5490 |
| MLA | ÇETIN HÜSEYIN,ATES AYSE SULE,Taydaş Ogün,Elmas Bahri,Guclu Ertugrul Magnetic resonance imaging findings in COVID-19-related anosmia. , 2022, ss.1506 - 1512. 10.55730/1300-0144.5490 |
| AMA | ÇETIN H,ATES A,Taydaş O,Elmas B,Guclu E Magnetic resonance imaging findings in COVID-19-related anosmia. . 2022; 1506 - 1512. 10.55730/1300-0144.5490 |
| Vancouver | ÇETIN H,ATES A,Taydaş O,Elmas B,Guclu E Magnetic resonance imaging findings in COVID-19-related anosmia. . 2022; 1506 - 1512. 10.55730/1300-0144.5490 |
| IEEE | ÇETIN H,ATES A,Taydaş O,Elmas B,Guclu E "Magnetic resonance imaging findings in COVID-19-related anosmia." , ss.1506 - 1512, 2022. 10.55730/1300-0144.5490 |
| ISNAD | ÇETIN, HÜSEYIN vd. "Magnetic resonance imaging findings in COVID-19-related anosmia". (2022), 1506-1512. https://doi.org/10.55730/1300-0144.5490 |
| APA | ÇETIN H, ATES A, Taydaş O, Elmas B, Guclu E (2022). Magnetic resonance imaging findings in COVID-19-related anosmia. Turkish Journal of Medical Sciences, 52(5), 1506 - 1512. 10.55730/1300-0144.5490 |
| Chicago | ÇETIN HÜSEYIN,ATES AYSE SULE,Taydaş Ogün,Elmas Bahri,Guclu Ertugrul Magnetic resonance imaging findings in COVID-19-related anosmia. Turkish Journal of Medical Sciences 52, no.5 (2022): 1506 - 1512. 10.55730/1300-0144.5490 |
| MLA | ÇETIN HÜSEYIN,ATES AYSE SULE,Taydaş Ogün,Elmas Bahri,Guclu Ertugrul Magnetic resonance imaging findings in COVID-19-related anosmia. Turkish Journal of Medical Sciences, vol.52, no.5, 2022, ss.1506 - 1512. 10.55730/1300-0144.5490 |
| AMA | ÇETIN H,ATES A,Taydaş O,Elmas B,Guclu E Magnetic resonance imaging findings in COVID-19-related anosmia. Turkish Journal of Medical Sciences. 2022; 52(5): 1506 - 1512. 10.55730/1300-0144.5490 |
| Vancouver | ÇETIN H,ATES A,Taydaş O,Elmas B,Guclu E Magnetic resonance imaging findings in COVID-19-related anosmia. Turkish Journal of Medical Sciences. 2022; 52(5): 1506 - 1512. 10.55730/1300-0144.5490 |
| IEEE | ÇETIN H,ATES A,Taydaş O,Elmas B,Guclu E "Magnetic resonance imaging findings in COVID-19-related anosmia." Turkish Journal of Medical Sciences, 52, ss.1506 - 1512, 2022. 10.55730/1300-0144.5490 |
| ISNAD | ÇETIN, HÜSEYIN vd. "Magnetic resonance imaging findings in COVID-19-related anosmia". Turkish Journal of Medical Sciences 52/5 (2022), 1506-1512. https://doi.org/10.55730/1300-0144.5490 |
