Yıl: 2022 Cilt: 12 Sayı: 2 Sayfa Aralığı: 345 - 348 Metin Dili: İngilizce DOI: 10.31832/smj.783277 İndeks Tarihi: 20-07-2023

Manuscript name: How We Treated a Kidney Transplant Recipient Who Was Receiving Sirolimus During the SARS-CoV-2 Pandemic? Primum Non Nocere.

Öz:
The new Coronavirus SARS-CoV-2 (COVID-19) epidemic continues to affect the world. It is emphasized that COVID-19 is more severe in patients with solid organ transplantation, and the risk of mortality may be higher than in the normal population. Herein, with the first time, we described a COVID-19 pneumoniae kidney recipient case treated with sirolimus. A 49-year-old male patient had kidney transplantation 13 years ago. He was used prednisolone and sirolimus. His main complaints were fever (38.3°C) and weakness. Atypical pneumoniae was diagnosed with thorax computed tomography. The respiratory specimen of the patient was positive with COVID-19 by PCR test. Sirolimus was stopped due to the immunosuppressive effect, and the treatment switched to low dose everolimus. Also, hydroxychloroquine, oseltamivir and azithromycin triple therapy was started for five days. The patient was discharged with healing on the seventh day.
Anahtar Kelime: COVID-19; Kidney transplantation; Sirolimus

SARS-CoV-2 Salgını Sırasında Sirolimus Alan Böbrek Nakli Alıcısını Nasıl Tedavi Ettik? İlk Önce Zarar Verme

Öz:
Yeni Koronavirüs SARS-CoV-2 (COVID-19) salgını dünyayı etkilemeye devam etmektedir. Organ nakli yapılan hastalarda COVID-19'un daha şiddetli olduğu ve ölüm riskinin normal popülasyona göre daha yüksek olabileceği vurgulanmaktadır. Burada ilk kez ; sirolimus ile tedavi edilen COVID-19 pnömonisi geçiren böbrek nakilli bir hastayı sunmayı amaçladık. On üç yıl önce böbrek nakli olan 49 yaşında erkek hasta 38.3°C ateş ve halsizlik şikayeti ile başvurdu. İmmünsupresif ilaç olarak prednizolon ve sirolimus kullanmakta olan hastanın toraks tomografisinde atipik pnömoni tanısı koyulup COVİD-19 PCR testi pozitif saptandı. İmmünsupretif etki nedeniyle sirolimus kesilerek everolimus tedavisine geçildi. Ayrıca hidroksiklorokin, oseltamivir ve azitromisin üçlü tedavisine beş gün süreyle başlandı. Hasta yedinci günde iyileşerek taburcu edildi.
Anahtar Kelime: COVID-19 ; Böbrek transplantasyonu ; Sirolimus

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
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  • 1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497–506.
  • 2. Fei Zhou, Ting Yu, Ronghui Du, Guohui Fan, Ying Liu, Zhibo Liu, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospec- tive cohort study. Lancet 2020 Mar 28;395(10229):1054-1062.
  • 3. Gandolfini I, Delsante M, Fiaccadori E, Zaza G, Manenti L, Degli Antoni A, et al. CO- VID-19 in Kidney Transplant Recipients. Am J Transplantation 2020 Jul;20(7):1941-1943.
  • 4. Zhang H, Chen Y, Yuan Q, Xia Q-X, Zeng X-P, Peng J-T, et al. Identification of Kidney Transplant Recipients with Coronavirus Disease 2019 EurUrol 2020 Jun;77(6):742-747.
  • 5. Guillen E, Pineiro GJ, Revuelta I, Rodriguez D, Bodro M, Moreno A, et al. Case report of COVID-19 in a kidney transplant recipient: Does immunosuppression alter the clinical presentation? Am J Transplantation 2020 Jul;20(7):1875-1878.
  • 6. Weiner SM, Sellin L, Vonend O, Schenker P, Buchner NJ, Flecken M, et al. Pneumonitis associated with sirolimus: clinical characteristics, risk factors and outcome--a single-centre experience and review of the literature. Nephrol Dial Transplant 2007;22:3631–7.
  • 7. Almeida F, Amorim S, Sarmento A, Santos L. Life -threatening everolimus-associated pneu- monitis: A case report and a review of the literature. Transplant Proc 2018 Apr;50(3):933- 938.
  • 8. Lee HS, Huh KH, Kim YS, Kim MS, Kim HJ, Kim SI, et al. Sirolimus-induced pneumoni- tis after renal transplantation: a single-center experience. Transplant Proc 2012;44:161–3.
  • 9. Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di Napoli R. Features, Evaluation and Treatment Coronavirus (COVID-19). StatPearls, Treasure Island (FL): StatPearls Publis- hing 2020.
APA dheir h, Sipahi S, Gündüz Y, Şenocak D, Genc A, KARABAY O (2022). Manuscript name: How We Treated a Kidney Transplant Recipient Who Was Receiving Sirolimus During the SARS-CoV-2 Pandemic? Primum Non Nocere.. , 345 - 348. 10.31832/smj.783277
Chicago dheir hamad,Sipahi Savaş,Gündüz Yasemin,Şenocak Didar,Genc Ahmed Bilal,KARABAY OĞUZ Manuscript name: How We Treated a Kidney Transplant Recipient Who Was Receiving Sirolimus During the SARS-CoV-2 Pandemic? Primum Non Nocere.. (2022): 345 - 348. 10.31832/smj.783277
MLA dheir hamad,Sipahi Savaş,Gündüz Yasemin,Şenocak Didar,Genc Ahmed Bilal,KARABAY OĞUZ Manuscript name: How We Treated a Kidney Transplant Recipient Who Was Receiving Sirolimus During the SARS-CoV-2 Pandemic? Primum Non Nocere.. , 2022, ss.345 - 348. 10.31832/smj.783277
AMA dheir h,Sipahi S,Gündüz Y,Şenocak D,Genc A,KARABAY O Manuscript name: How We Treated a Kidney Transplant Recipient Who Was Receiving Sirolimus During the SARS-CoV-2 Pandemic? Primum Non Nocere.. . 2022; 345 - 348. 10.31832/smj.783277
Vancouver dheir h,Sipahi S,Gündüz Y,Şenocak D,Genc A,KARABAY O Manuscript name: How We Treated a Kidney Transplant Recipient Who Was Receiving Sirolimus During the SARS-CoV-2 Pandemic? Primum Non Nocere.. . 2022; 345 - 348. 10.31832/smj.783277
IEEE dheir h,Sipahi S,Gündüz Y,Şenocak D,Genc A,KARABAY O "Manuscript name: How We Treated a Kidney Transplant Recipient Who Was Receiving Sirolimus During the SARS-CoV-2 Pandemic? Primum Non Nocere.." , ss.345 - 348, 2022. 10.31832/smj.783277
ISNAD dheir, hamad vd. "Manuscript name: How We Treated a Kidney Transplant Recipient Who Was Receiving Sirolimus During the SARS-CoV-2 Pandemic? Primum Non Nocere.". (2022), 345-348. https://doi.org/10.31832/smj.783277
APA dheir h, Sipahi S, Gündüz Y, Şenocak D, Genc A, KARABAY O (2022). Manuscript name: How We Treated a Kidney Transplant Recipient Who Was Receiving Sirolimus During the SARS-CoV-2 Pandemic? Primum Non Nocere.. Sakarya Tıp Dergisi, 12(2), 345 - 348. 10.31832/smj.783277
Chicago dheir hamad,Sipahi Savaş,Gündüz Yasemin,Şenocak Didar,Genc Ahmed Bilal,KARABAY OĞUZ Manuscript name: How We Treated a Kidney Transplant Recipient Who Was Receiving Sirolimus During the SARS-CoV-2 Pandemic? Primum Non Nocere.. Sakarya Tıp Dergisi 12, no.2 (2022): 345 - 348. 10.31832/smj.783277
MLA dheir hamad,Sipahi Savaş,Gündüz Yasemin,Şenocak Didar,Genc Ahmed Bilal,KARABAY OĞUZ Manuscript name: How We Treated a Kidney Transplant Recipient Who Was Receiving Sirolimus During the SARS-CoV-2 Pandemic? Primum Non Nocere.. Sakarya Tıp Dergisi, vol.12, no.2, 2022, ss.345 - 348. 10.31832/smj.783277
AMA dheir h,Sipahi S,Gündüz Y,Şenocak D,Genc A,KARABAY O Manuscript name: How We Treated a Kidney Transplant Recipient Who Was Receiving Sirolimus During the SARS-CoV-2 Pandemic? Primum Non Nocere.. Sakarya Tıp Dergisi. 2022; 12(2): 345 - 348. 10.31832/smj.783277
Vancouver dheir h,Sipahi S,Gündüz Y,Şenocak D,Genc A,KARABAY O Manuscript name: How We Treated a Kidney Transplant Recipient Who Was Receiving Sirolimus During the SARS-CoV-2 Pandemic? Primum Non Nocere.. Sakarya Tıp Dergisi. 2022; 12(2): 345 - 348. 10.31832/smj.783277
IEEE dheir h,Sipahi S,Gündüz Y,Şenocak D,Genc A,KARABAY O "Manuscript name: How We Treated a Kidney Transplant Recipient Who Was Receiving Sirolimus During the SARS-CoV-2 Pandemic? Primum Non Nocere.." Sakarya Tıp Dergisi, 12, ss.345 - 348, 2022. 10.31832/smj.783277
ISNAD dheir, hamad vd. "Manuscript name: How We Treated a Kidney Transplant Recipient Who Was Receiving Sirolimus During the SARS-CoV-2 Pandemic? Primum Non Nocere.". Sakarya Tıp Dergisi 12/2 (2022), 345-348. https://doi.org/10.31832/smj.783277