Yıl: 2023 Cilt: 8 Sayı: 3 Sayfa Aralığı: 363 - 368 Metin Dili: İngilizce DOI: 10.26453/otjhs.1276809 İndeks Tarihi: 11-09-2023

Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease

Öz:
Objective: Interferon-gamma inducible protein-10 (IP- 10) released from macrophages is associated with thrombosis. We aimed to investigate patients' biochemical markers following severe COVID-19, concentrating on the role of IP-10 in mortality. Materials and Methods: In our study, we retrospectively evaluated data from 88 (females, 44.3%) severe patients followed in our university hospital's intensive care unit (ICU). We obtained demographic and laboratory data from our study population's files and electronic records, including D-dimer, ferritin, uric acid, IP-10 values, and other biochemical markers. Results: The mean age of all 88 patients with COVID-19 infection followed in the ICU was 70.5 ±10 years. The median for lymphocyte count was 1.3 (1-2.1) vs 0.8 (0.5- 1.1) K/uL, ferritin 151 (90.7-255) vs 624 (296-1254) mcg/ L, D-dimer 386 (293.5-650) vs 1280 (871-2245) ug/L, LDH 220 (185-286) vs 429.5 (368-560) U/L with a p- value of <0.05 in survivors vs non-survivors respectively. On the other hand, the level of IP-10 was 21.3 (13.2-31.6) vs 26.6 (11.4-43.6) pg/mL with a p-value of 0.04. Conclusion: In this study, in which non-survivors and survivors were compared in severe COVID-19 patients, it was found that ferritin and D-dimer were good predictors of mortality, while IP-10 could not be a predictor of mortality.
Anahtar Kelime: Biomarker COVID-19 IP-10 mortality

İnterferon-gamma ile İndüklenebilir Protein-10: COVID-19 Hastalığı için Bir Ölüm Göstergesi Değildir

Öz:
Amaç: Makrofajlardan salınan interferon-gama indükle- nebilir protein-10 (IP-10) tromboz ile ilişkilidir. Bu çalış- ma, şiddetli COVID-19 nedeniyle takip edilen hastaların biyokimyasal belirteçlerini ve IP-10'un mortaliteyi göster- medeki rolünü araştırmayı amaçladı. Materyal ve Metot: Bu çalışmada üniversite hastanesinin yoğun bakım ünitesinde (YBÜ) takip edilen 88 (Kadın % 44,3) ağır hastanın retrospektif verileri değerlendirildi. De- mografik ve laboratuvar verileri ile D-dimer, Ferritin, Ürik asit, IP-10 değerleri ve diğer biyokimyasal belirteçlere ilişkin veriler ölen ve yaşayan hastaların dosyalarından elde edildi. Bulgular: Yoğun bakımda takip edilen COVID-19 enfeksi- yonlu 88 hastanın yaş ortalaması 70,5 ±10 idi. Hayatta kalan gurupta, lenfosit sayısı 1,3 (1-2,1) K/uL, ferritin 151 (90,7- 255), D-dimer 386 (293,5-650), LDH 220 (185-286) iken, ölen hastalarda ise, lenfosit sayısı 0,8 (0,5-1,1), ferritin 624 (296-1254) mcg/L, D-dimer 1280 (871-2245) ug/L, LDH 429.5 (368-560) U/L saptandı. Bu parametrelerde p değeri <0,05 idi. Buna karşılık, hayatta kalmayanlarda serum IP-10 seviyeleri hayatta kalanlar da 21,3 (1,2-31,6) pg/mL iken ölen hastalarda 26,6 (11,4-43,6) pg/mL, p=0,04. Sonuç: Şiddetli COVID-19 hastalarında hayatta kalmayanlar ve hayatta kalanların karşılaştırıldığı bu çalışmada, ferritin, ve D-dimerin mortalite için iyi bir tahmin edici potansiyeli olduğu, IP-10'un ise bir belirleyici olamayacağı bulundu.
Anahtar Kelime: Biyobelirteç COVID-19 IP-10 mortalite

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
0
0
0
  • 1. Chen Y, Wang J, Liu C, Su L, Zhang D, Fan J, et al. IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19. Mol Med. 2020;26(1):97. doi:10.1186/s10020-020-00230-x
  • 2. Clinical spectrum. COVID-19 Treatment Guidelines. https:// www.covid19treatmentguidelines.nih.gov/ overview/clinical-spectrum/. Accessed May 19, 2023.
  • 3. Corominas H, Castellví I, Pomar V, Antonijoan R, Mur I, Matas L, et al. Effectiveness and safety of intravenous tocilizumab to treat COVID-19associated hyperinflammatory syndrome: Covizumab-6 observational cohort. Clin Immunol. 2021;223:108631. doi:10.1016/ j.clim.2020.108631
  • 4. Buszko M, Park JH, Verthelyi D, Sen R, Young HA, Rosenberg AS. The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge. Nat Immunol. 2020;21(10):1146-1151. doi:10.1038/s41590-020 -0779-1
  • 5. Schultze JL, Aschenbrenner AC. COVID-19 and the human innate immune system. Cell. 2021;184 (7):1671-1692. doi:10.1016/j.cell.2021.02.029
  • 6. Bignon E, Miclot T, Terenzi A, Barone G, Monari A. Structure of the 5’ untranslated region in SARS-CoV-2 genome and its specific recognition by innate immune system via the human oligoadenylate synthase 1. Chem Commun . 2022;58(13):2176-2179. doi:10.1039/ d1cc07006a
  • 7. Lu Q, Zhu Z, Tan C, Zhou H, Hu Y, Shen G, et al. Changes of serum IL-10, IL-1β, IL-6, MCP-1, TNF-α, IP-10 and IL-4 in COVID-19 patients. Int J Clin Pract. 2021;75(9):e14462. doi:10.1111/ ijcp.14462
  • 8. Sriram K, Insel PA. Inflammation and thrombosis in COVID-19 pathophysiology: proteinaseactivated and purinergic receptors as drivers and candidate therapeutic targets. Physiol Rev. 2021;101(2):545-567. doi:10.1152/ physrev.00035.2020
  • 9. Lev S, Gottesman T, Sahaf Levin G, Lederfein D, Berkov E, Diker D, et al. Observational cohort study of IP-10’s potential as a biomarker to aid in inflammation regulation within a clinical decision support protocol for patients with severe COVID-19. PLoS One. 2021;16(1):e0245296. doi:10.1371/journal.pone.0245296
  • 10. M Hussein A, Taha ZB, Gailan Malek A, Akram Rasul K, Hazim Kasim D, Jalal Ahmed R, et al. D-Dimer and Serum ferritin as an Independent Risk Factor for Severity in COVID-19 Patients. Mater Today Proc. Published online April 13, 2021. doi:10.1016/j.matpr.2021.04.009
  • 11.Xie H, Zhao J, Lian N, Lin S, Xie Q, Zhuo H. Clinical characteristics of non-ICU hospitalized patients with coronavirus disease 2019 and liver injury: A retrospective study. Liver Int. 2020;40 (6):1321-1326. doi:10.1111/liv.14449
  • 12.Buszko M, Nita-Lazar A, Park JH, Schwartzberg PL, Verthelyi D, Young HA, et al. Lessons learned: new insights on the role of cytokines in COVID-19. Nat Immunol. 2021;22(4):404-411. doi:10.1038/s41590-021-00901-9
  • 13.Liu M, Guo S, Stiles JK. The emerging role of CXCL10 in cancer (Review). Oncol Lett. 2011;2 (4):583-589. doi:10.3892/ol.2011.300
  • 14.Yang Y, Shen C, Li J, Yuan J, Wei J, Huang F, et al. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. J Allergy Clin Immunol. 2020;146(1):119-127.e4. doi:10.1016/ j.jaci.2020.04.027
  • 15.Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi:10.1016/S0140- 6736(20)30183-5
  • 16.Rizzi M, Costanzo M, Tonello S, Matino E, Casciaro FG, Croce A, et al. Prognostic Markers in Hospitalized COVID-19 Patients: The Role of IP -10 and C-Reactive Protein. Dis Markers. 2022;2022:3528312. doi:10.1155/2022/3528312
  • 17.Mulla S, Molla MMA, Ahmed SMA, Akhtaruzzaman AKM, Saleh AA, Anwar S. Association of interferon gamma inducible protein-10, monocyte chemoattractant protein-1, macrophage inflammatory protein-1 alpha, interleukin-6, and rs12252 single nucleotide polymorphism of interferon-induced transmembrane protein-3 gene with the severity of COVID-19 infection. Egypt J Intern Med. 2022;34(1):53. doi:10.1186/s43162- 022-00141-9
APA İSLAM M, dheir h, özözen şahin e, YAYLACI S, Aydın A, pınar m, Guclu E, GENC A, Koroglu M, KARABAY O (2023). Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease. , 363 - 368. 10.26453/otjhs.1276809
Chicago İSLAM MAHMUD,dheir hamad,özözen şahin elif,YAYLACI SELÇUK,Aydın Abdülkadir,pınar musa,Guclu Ertugrul,GENC AHMED CIHAD,Koroglu Mehmet,KARABAY OĞUZ Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease. (2023): 363 - 368. 10.26453/otjhs.1276809
MLA İSLAM MAHMUD,dheir hamad,özözen şahin elif,YAYLACI SELÇUK,Aydın Abdülkadir,pınar musa,Guclu Ertugrul,GENC AHMED CIHAD,Koroglu Mehmet,KARABAY OĞUZ Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease. , 2023, ss.363 - 368. 10.26453/otjhs.1276809
AMA İSLAM M,dheir h,özözen şahin e,YAYLACI S,Aydın A,pınar m,Guclu E,GENC A,Koroglu M,KARABAY O Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease. . 2023; 363 - 368. 10.26453/otjhs.1276809
Vancouver İSLAM M,dheir h,özözen şahin e,YAYLACI S,Aydın A,pınar m,Guclu E,GENC A,Koroglu M,KARABAY O Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease. . 2023; 363 - 368. 10.26453/otjhs.1276809
IEEE İSLAM M,dheir h,özözen şahin e,YAYLACI S,Aydın A,pınar m,Guclu E,GENC A,Koroglu M,KARABAY O "Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease." , ss.363 - 368, 2023. 10.26453/otjhs.1276809
ISNAD İSLAM, MAHMUD vd. "Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease". (2023), 363-368. https://doi.org/10.26453/otjhs.1276809
APA İSLAM M, dheir h, özözen şahin e, YAYLACI S, Aydın A, pınar m, Guclu E, GENC A, Koroglu M, KARABAY O (2023). Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease. Online Türk Sağlık Bilimleri Dergisi, 8(3), 363 - 368. 10.26453/otjhs.1276809
Chicago İSLAM MAHMUD,dheir hamad,özözen şahin elif,YAYLACI SELÇUK,Aydın Abdülkadir,pınar musa,Guclu Ertugrul,GENC AHMED CIHAD,Koroglu Mehmet,KARABAY OĞUZ Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease. Online Türk Sağlık Bilimleri Dergisi 8, no.3 (2023): 363 - 368. 10.26453/otjhs.1276809
MLA İSLAM MAHMUD,dheir hamad,özözen şahin elif,YAYLACI SELÇUK,Aydın Abdülkadir,pınar musa,Guclu Ertugrul,GENC AHMED CIHAD,Koroglu Mehmet,KARABAY OĞUZ Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease. Online Türk Sağlık Bilimleri Dergisi, vol.8, no.3, 2023, ss.363 - 368. 10.26453/otjhs.1276809
AMA İSLAM M,dheir h,özözen şahin e,YAYLACI S,Aydın A,pınar m,Guclu E,GENC A,Koroglu M,KARABAY O Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease. Online Türk Sağlık Bilimleri Dergisi. 2023; 8(3): 363 - 368. 10.26453/otjhs.1276809
Vancouver İSLAM M,dheir h,özözen şahin e,YAYLACI S,Aydın A,pınar m,Guclu E,GENC A,Koroglu M,KARABAY O Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease. Online Türk Sağlık Bilimleri Dergisi. 2023; 8(3): 363 - 368. 10.26453/otjhs.1276809
IEEE İSLAM M,dheir h,özözen şahin e,YAYLACI S,Aydın A,pınar m,Guclu E,GENC A,Koroglu M,KARABAY O "Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease." Online Türk Sağlık Bilimleri Dergisi, 8, ss.363 - 368, 2023. 10.26453/otjhs.1276809
ISNAD İSLAM, MAHMUD vd. "Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease". Online Türk Sağlık Bilimleri Dergisi 8/3 (2023), 363-368. https://doi.org/10.26453/otjhs.1276809