TY  - JOUR
TI  - Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease
AB  - Objective: Interferon-gamma inducible protein-10 (IP- 10) released from macrophages is associated with thrombosis. We aimed to investigate patients' biochemical markers following severe COVID-19, concentrating on the role of IP-10 in mortality. Materials and Methods: In our study, we retrospectively evaluated data from 88 (females, 44.3%) severe patients followed in our university hospital's intensive care unit (ICU). We obtained demographic and laboratory data from our study population's files and electronic records, including D-dimer, ferritin, uric acid, IP-10 values, and other biochemical markers. Results: The mean age of all 88 patients with COVID-19 infection followed in the ICU was 70.5 ±10 years. The median for lymphocyte count was 1.3 (1-2.1) vs 0.8 (0.5- 1.1) K/uL, ferritin 151 (90.7-255) vs 624 (296-1254) mcg/ L, D-dimer 386 (293.5-650) vs 1280 (871-2245) ug/L, LDH 220 (185-286) vs 429.5 (368-560) U/L with a p- value of <0.05 in survivors vs non-survivors respectively. On the other hand, the level of IP-10 was 21.3 (13.2-31.6) vs 26.6 (11.4-43.6) pg/mL with a p-value of 0.04. Conclusion: In this study, in which non-survivors and survivors were compared in severe COVID-19 patients, it was found that ferritin and D-dimer were good predictors of mortality, while IP-10 could not be a predictor of mortality.
AU  - Guclu, Ertugrul
AU  - İSLAM, MAHMUD
AU  - dheir, hamad
AU  - özözen şahin, elif
AU  - YAYLACI, SELÇUK
AU  - Aydın, Abdülkadir
AU  - pınar, musa
AU  - GENC, AHMED CIHAD
AU  - Koroglu, Mehmet
AU  - KARABAY, OĞUZ
DO  - 10.26453/otjhs.1276809
PY  - 2023
JO  - Online Türk Sağlık Bilimleri Dergisi
VL  - 8
IS  - 3
SN  - 2459-1467
SP  - 363
EP  - 368
DB  - TRDizin
UR  - http://search/yayin/detay/1195708
ER  -