Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model
Yıl: 2023 Cilt: 8 Sayı: 4 Sayfa Aralığı: 525 - 532 Metin Dili: İngilizce DOI: 10.26453/otjhs.1374368 İndeks Tarihi: 24-12-2023
Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model
Öz: Objective: Adipokinetic hormone (AKH) plays a role in sugar and lipid metabolism in insects. Previous studies of AKH showed memory improvements in a schizophrenia rat model that displayed memory impairment and reduced depression in a rat olfactory bulbectomy model. In this study, we investigated the effects of the adipokinetic hormone/red pigment-concentrating hormone (AKH/RPCH) family of peptides on brain neurotransmitter levels and brain neurochemistry in a schizophrenia rat model. Materials and Methods: We administered AKH/RPCH peptides for 4 days sub-chronically, both in naive rats and also in the MK-801-induced schizophrenia rat model. Liquid chromatography-mass spectrometry apparatus was used for targeted and untargeted analysis of rat neurochemistry. Results: Increased brain glutamate levels characteristic of MK-801 peptide-treated rats were significantly reduced by AKH. Furthermore, AKH also increased brain dopamine levels in both naive and MK-801 rats. Metabolomic studies have shown that AKH affects lipid and glutamate metabolism, while hypertrehalosaemic hormone plays a role in sugar metabolism and inflammation. Conclusion: According to our results, AKH might affect dopaminergic and glutamatergic systems and reverse the effects of MK-801, possibly affecting NMDA receptors.
Anahtar Kelime: Adipokinetik Hormon/Kırmızı Pigment Konsantre Hormon Peptid Ailesinin MK-801'in İndüklediği Şizofreni Sıçan Modelinde Nörokimyasal Etkileri
Öz: Amaç: Adipokinetik hormon (AKH) böceklerde şeker ve lipid metabolizmasında rol oynar. Önceki çalışmalarda AKH sıçan şizofeni modelinde belleği ve sıçan olfaktör bulbektomi modelinde depresyonu düzelttiği gösterilmiştir. Bu çalışmada, adipokinetik hormon/kırmızı pigment konsantre edici hormon (AKH/RPCH) ailesi peptidlerinin sıçan şizofreni modelinde beyin nörotransmitter seviyesi ve beyin nörokimyası üzerine etkisi araştırılmıştır. Materyal ve Metot: Peptidleri hem naif sıçanlarda hem de MK-801 ile indüklenmiş sıçan şizofreni modelinde 4 gün boyunca subkronik olarak uyguladık. Likid kromatografi-kütle spektrometri cihazı nörokimyanın hedeflenmiş ve hedeflenmemiş analizi için kullanıldı. Bulgular: AKH anlamlı olarak MK-801 uygulanmış sıçanlarda artmış beyin glutamat seviyesini düşürmüştür. AKH ayrıca hem naif sıçanlarda hem MK-801 uygulanmış sıçanlarda beyin dopamin seviyesini artırdı. Metabolomik çalışmalar adipokinetik hormonun lipid ve glutamat metabolizmasını etkilediğini, hipertrehalosemik hormonun ise şeker metabolizması ve enflamasyonda rol oynadığını gösterdi. Sonuç: Sonuçlarımıza göre AKH dopaminerjik ve glutamaterjik sistemi etkileyebilir ve MK-801’in etkilerini muhtemelen NMDA reseptörleri üzerinden tersine çeviriyor olabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Başarır Bozkurt Ş, Mutlu O, Bermejo Rodriguez D, Kacer D, tanyeri p, COBANTÜRK P, Valeš K (2023). Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model. , 525 - 532. 10.26453/otjhs.1374368 |
| Chicago | Başarır Bozkurt Şeyma Nur,Mutlu Oguz,Bermejo Rodriguez Daniel,Kacer David,tanyeri pelin,COBANTÜRK PINAR,Valeš Karel Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model. (2023): 525 - 532. 10.26453/otjhs.1374368 |
| MLA | Başarır Bozkurt Şeyma Nur,Mutlu Oguz,Bermejo Rodriguez Daniel,Kacer David,tanyeri pelin,COBANTÜRK PINAR,Valeš Karel Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model. , 2023, ss.525 - 532. 10.26453/otjhs.1374368 |
| AMA | Başarır Bozkurt Ş,Mutlu O,Bermejo Rodriguez D,Kacer D,tanyeri p,COBANTÜRK P,Valeš K Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model. . 2023; 525 - 532. 10.26453/otjhs.1374368 |
| Vancouver | Başarır Bozkurt Ş,Mutlu O,Bermejo Rodriguez D,Kacer D,tanyeri p,COBANTÜRK P,Valeš K Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model. . 2023; 525 - 532. 10.26453/otjhs.1374368 |
| IEEE | Başarır Bozkurt Ş,Mutlu O,Bermejo Rodriguez D,Kacer D,tanyeri p,COBANTÜRK P,Valeš K "Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model." , ss.525 - 532, 2023. 10.26453/otjhs.1374368 |
| ISNAD | Başarır Bozkurt, Şeyma Nur vd. "Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model". (2023), 525-532. https://doi.org/10.26453/otjhs.1374368 |
| APA | Başarır Bozkurt Ş, Mutlu O, Bermejo Rodriguez D, Kacer D, tanyeri p, COBANTÜRK P, Valeš K (2023). Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model. Online Türk Sağlık Bilimleri Dergisi, 8(4), 525 - 532. 10.26453/otjhs.1374368 |
| Chicago | Başarır Bozkurt Şeyma Nur,Mutlu Oguz,Bermejo Rodriguez Daniel,Kacer David,tanyeri pelin,COBANTÜRK PINAR,Valeš Karel Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model. Online Türk Sağlık Bilimleri Dergisi 8, no.4 (2023): 525 - 532. 10.26453/otjhs.1374368 |
| MLA | Başarır Bozkurt Şeyma Nur,Mutlu Oguz,Bermejo Rodriguez Daniel,Kacer David,tanyeri pelin,COBANTÜRK PINAR,Valeš Karel Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model. Online Türk Sağlık Bilimleri Dergisi, vol.8, no.4, 2023, ss.525 - 532. 10.26453/otjhs.1374368 |
| AMA | Başarır Bozkurt Ş,Mutlu O,Bermejo Rodriguez D,Kacer D,tanyeri p,COBANTÜRK P,Valeš K Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model. Online Türk Sağlık Bilimleri Dergisi. 2023; 8(4): 525 - 532. 10.26453/otjhs.1374368 |
| Vancouver | Başarır Bozkurt Ş,Mutlu O,Bermejo Rodriguez D,Kacer D,tanyeri p,COBANTÜRK P,Valeš K Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model. Online Türk Sağlık Bilimleri Dergisi. 2023; 8(4): 525 - 532. 10.26453/otjhs.1374368 |
| IEEE | Başarır Bozkurt Ş,Mutlu O,Bermejo Rodriguez D,Kacer D,tanyeri p,COBANTÜRK P,Valeš K "Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model." Online Türk Sağlık Bilimleri Dergisi, 8, ss.525 - 532, 2023. 10.26453/otjhs.1374368 |
| ISNAD | Başarır Bozkurt, Şeyma Nur vd. "Neurochemical Effects of the Adipokinetic Hormone/Red Pigment Concentrating Hormone Family of Peptides in MK-801-Induced Schizophrenia Rat Model". Online Türk Sağlık Bilimleri Dergisi 8/4 (2023), 525-532. https://doi.org/10.26453/otjhs.1374368 |
