Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine

SEYFİKLİ, Zehra; doruk, sibel; AKSIT, HÜSEYIN; DEMİRTAŞ, İbrahim; Erkorkmaz, Ünal

Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine

Sibel DORUK, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Tokat, Türkiye)

İbrahim DEMİRTAŞ, (Çankırı Karatekin Üniversitesi, Çankırı, Türkiye)

Hüseyin AKŞİT, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Tokat, Türkiye)

Ünal ERKORKMAZ, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Tokat, Türkiye)

Zehra SEYFİKLİ (Cumhuriyet Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Sivas, Türkiye)

Turkish Journal of Medical Sciences

4 0

Yıl: 2012 Cilt: 42 Sayı: 4 Sayfa Aralığı: 739 - 745 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine

Öz:

Amaç: Tütün dumanı maruziyetinin soluk havasındaki karbonmonoksit (eCO) ve saçtaki nikotin düzeyine etkisini saptamayı ve bu yöntemler arasındaki ilişkiyi belirlemek. Yöntem ve gereç: Çalışmaya 3 grup olarak 96 olgu (64/32 erkek/kadın) çalışmaya alındı. Grup 1 (n = 46) sigara içicisi idi, Grup 2 (n = 20) ve Grup 3 (n = 30) sigara içmeyen ancak çevresel tütün dumanı olan ya da olmayan olgulardı. Tüm olgularda CO monitörü ile eCO düzeyi ölçüldü. Saçta nikotin konsantrasyonunu belirlemede (n = 47) gaz kromatografi / kütle spektrometri yöntemi kullanıldı. Bulgular: Olguların yaş ortalaması 39,1 idi. Ortalama eCO düzeyi gruplarda 9,3 ppm, 1,3 ppm ve 1,0 ppm ve saçta nikotin konsantrasyonu sırasıyla 20,9 ng/mg, 2,1 ng/mg ve 0,7 ng/mg idi. eCO düzeyleri ve saçta nikotin konsantrasyonu açısından Grup 1 ile diğer gruplar arasında farklılık saptandı ancak eCO düzeyleri ve saçta nikotin konsantrasyonu. Grup 2 ve Grup 3’de benzerdi. eCO düzeyleri ile saç nikotin konsantrasyonları arasında pozitif ilişki saptandı. Sigara içicilerinde eCO ve saçta nikotin için eşik değerleri sırasıyla 6 ppm ve 4 ng/mg idi. Sonuç: Saç gibi çeşitli biyolojik örneklerde nikotin analizi tütün dumanı maruziyeti için spesifik olmasına rağmen bu yöntemler pahalı ve zordur. Sonuçlarımız saç nikotin analizi yerine eCO ölçümü gibi ucuz ve kolay bir yöntemin kullanabileceğini desteklese de daha fazla sayıda olgu içeren yeni çalışmalara gereksinim vardır.

Anahtar Kelime: Ekshalasyon Çevresel maruziyet Sigara dumanı kirliliği Spektrofotometri Saç Sigara içme Nikotin

Konular: Cerrahi

Tütün dumanı maruziyetinin değerlendirilmesi: Soluk havasında karbonmonoksit ve saçta nikotin ölçümü

Öz:

Aim: To investigate the effect of tobacco smoke (TS) exposure on the quantity of exhaled carbon monoxide (eCO) and hair nicotine (HN) and to evaluate the relationship between these values. Materials and methods: Included in the study were 96 subjects (64 male, 32 female) divided into 3 groups. The subjects in Group 1 (n = 46) were current smokers, and the subjects in Group 2 (n = 20) and Group 3 (n = 30) were nonsmokers with or without environmental TS exposure, respectively. The eCO level of all of the subjects was measured with a breath CO monitor. Gas chromatography/mass spectrometry were used for quantifi cation of the HN (n = 47). Results: The mean age of the subjects was 39.1 years. The mean levels of eCO were 9.3 ppm, 1.3 ppm, and 1.0 ppm and the mean HN concentrations were 20.9 ng/mg, 2.1 ng/mg, and 0.7 ng/mg in the 3 groups, respectively. There was a significant difference between Group 1 and the other groups according to the levels of eCO and HN concentrations, but the levels of eCO and HN concentrations were similar in Group 2 and Group 3. There was a positive correlation between the levels of eCO and the HN concentrations. The cutoff values of eCO and HN for smokers were 6 ppm and 4 ng/mg, respectively. Conclusion: Although nicotine analysis in some biological samples like hair is specific to TS exposure, these methods are expensive and difficult procedures. Our results suggest that instead of HN analysis, a cheap and easy method like eCO measurement may be used, but further studies with more cases are needed.

Anahtar Kelime: Hair Smoking Nicotine Exhalation Environmental Exposure Tobacco Smoke Pollution Spectrophotometry

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	doruk s, DEMİRTAŞ İ, AKSIT H, Erkorkmaz Ü, SEYFİKLİ Z (2012). Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine. , 739 - 745.
Chicago	doruk sibel,DEMİRTAŞ İbrahim,AKSIT HÜSEYIN,Erkorkmaz Ünal,SEYFİKLİ Zehra Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine. (2012): 739 - 745.
MLA	doruk sibel,DEMİRTAŞ İbrahim,AKSIT HÜSEYIN,Erkorkmaz Ünal,SEYFİKLİ Zehra Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine. , 2012, ss.739 - 745.
AMA	doruk s,DEMİRTAŞ İ,AKSIT H,Erkorkmaz Ü,SEYFİKLİ Z Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine. . 2012; 739 - 745.
Vancouver	doruk s,DEMİRTAŞ İ,AKSIT H,Erkorkmaz Ü,SEYFİKLİ Z Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine. . 2012; 739 - 745.
IEEE	doruk s,DEMİRTAŞ İ,AKSIT H,Erkorkmaz Ü,SEYFİKLİ Z "Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine." , ss.739 - 745, 2012.
ISNAD	doruk, sibel vd. "Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine". (2012), 739-745.

APA	doruk s, DEMİRTAŞ İ, AKSIT H, Erkorkmaz Ü, SEYFİKLİ Z (2012). Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine. Turkish Journal of Medical Sciences, 42(4), 739 - 745.
Chicago	doruk sibel,DEMİRTAŞ İbrahim,AKSIT HÜSEYIN,Erkorkmaz Ünal,SEYFİKLİ Zehra Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine. Turkish Journal of Medical Sciences 42, no.4 (2012): 739 - 745.
MLA	doruk sibel,DEMİRTAŞ İbrahim,AKSIT HÜSEYIN,Erkorkmaz Ünal,SEYFİKLİ Zehra Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine. Turkish Journal of Medical Sciences, vol.42, no.4, 2012, ss.739 - 745.
AMA	doruk s,DEMİRTAŞ İ,AKSIT H,Erkorkmaz Ü,SEYFİKLİ Z Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine. Turkish Journal of Medical Sciences. 2012; 42(4): 739 - 745.
Vancouver	doruk s,DEMİRTAŞ İ,AKSIT H,Erkorkmaz Ü,SEYFİKLİ Z Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine. Turkish Journal of Medical Sciences. 2012; 42(4): 739 - 745.
IEEE	doruk s,DEMİRTAŞ İ,AKSIT H,Erkorkmaz Ü,SEYFİKLİ Z "Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine." Turkish Journal of Medical Sciences, 42, ss.739 - 745, 2012.
ISNAD	doruk, sibel vd. "Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine". Turkish Journal of Medical Sciences 42/4 (2012), 739-745.