Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis

BİLGİLİ, Memet Erşan; SARAÇOĞLU, Zeynep Nurhan; Sabuncu, Ilham; ASLAN, Abdurrahman; Yıldız, Hamza

Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis

Memet Erşan BİLGİLİ, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Eskişehir, Türkiye)

Zeynep Nurhan SARAÇOĞLU, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Eskişehir, Türkiye)

Hamza YILDIZ, (Eskişehir Askeri Hastanesi, Eskişehir, Türkiye)

Abdurrahman ASLAN, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Eskişehir, Türkiye)

İlham SABUNCU (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Eskişehir, Türkiye)

Journal of Clinical and Analytical Medicine

17 0

Yıl: 2015 Cilt: 6 Sayı: 1 Sayfa Aralığı: 37 - 40 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis

Öz:

Amaç: Bu çalışmanın amacı intertriginöz tinea pedis tedavisinde oral terbinafin ve itrakonazolun etkinliğinin ve güvenirliğinin değerlenmekti. Gereç veYöntem: Klinik ve mikolojik olarak intertriginöz tinea pedis tanısı konan 60hasta çalışmaya alındı. Hastalar iki gruba ayrıldı. Birinci grup iki hafta boyunca 250 mg oral terbinafin (n:30) aldı. İkinci grup yedi gün boyunca 200mg itrakonazol tedavisi aldı. İlk muayenede ve çalışmaya başladıktan sonraki 15, 30, 60ıncı günlerde semptom ve bulgular kliniksel olarak değerlendirildi ve mikolojik değerlendirme için örnek alındı. Bulgular: İlk muayeneden sonra kontrol muayenelerine gelmeyen 6 hasta çalışma dışında bırakıldı. Tedavinin etkinliği 15, 30, 60ıncı günlerde değerlendirildi. Birinci kontrolde terbinafin grubunda %57.1 ve itrakonazol grubunda %46.1 oranında semptomlarkayboldu. İkinci kontrolde terbinafin grubunda tedavi başarısı %82.1, itrakonazol grubunda %73.1 idi. 60ıncı günde kür oranları benzerdi (terbinafin için%89.3, itrakonazol için %84.6). İki grup arasında istatistiksel olarak anlamlıfark saptanmadı. Tartışma: İntertriginöz tinea pedis tedavisinde oral terbinafin ve itrakonazol benzer etkinlik ve tolerabiliteye sahiptir.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Tinea Pedis Tedavisinde Oral Terbinafin ve İtrakonazolun Karşılaştırılması

Öz:

Aim: The aim of this study was to evaluate the efficacy and safety of oralterbinafine and itraconazole in the treatment of the patients with interdigitaltinea pedis. Material and Method: A total 60 patients with clinically and my- cologically diagnosed as interdigital tinea pedis were enrolled to the study.Patients were divided into two groups. The first group received oral terbin- afine 250 mg/day for two weeks (n:30). The second group received itracon- azole 200 mg daily for 7 days (n:30). At the first visit and 15, 30, 60 daysafter the start of the study, signs and symptoms were assessed clinically andscales were taken for mycological assessments. Results: Six patients who didnot return after the first visit were excluded from the study (2 on terbinafine,4 on itraconazole). The effectiveness of therapy was evaluated at day 15, 30,60. Symptoms were absent in 57.1% of terbinafine group and 46.1% of theitraconazole group in the first control. The effectiveness of the terbinafinegroup was 82.1% and 73.1% of the itraconazole group in second control. Atday 60, the cure rates were similar (89.3% for terbinafine, 84.6% for itraconazole). No statistical significant differences between the two groups was observed (p>0.05). Discussion: Oral terbinafine and itraconazole have the sameeffectiveness and tolerability in the treatment of interdigital tinea pedis.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	BİLGİLİ M, SARAÇOĞLU Z, Yıldız H, ASLAN A, Sabuncu I (2015). Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis. , 37 - 40.
Chicago	BİLGİLİ Memet Erşan,SARAÇOĞLU Zeynep Nurhan,Yıldız Hamza,ASLAN Abdurrahman,Sabuncu Ilham Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis. (2015): 37 - 40.
MLA	BİLGİLİ Memet Erşan,SARAÇOĞLU Zeynep Nurhan,Yıldız Hamza,ASLAN Abdurrahman,Sabuncu Ilham Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis. , 2015, ss.37 - 40.
AMA	BİLGİLİ M,SARAÇOĞLU Z,Yıldız H,ASLAN A,Sabuncu I Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis. . 2015; 37 - 40.
Vancouver	BİLGİLİ M,SARAÇOĞLU Z,Yıldız H,ASLAN A,Sabuncu I Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis. . 2015; 37 - 40.
IEEE	BİLGİLİ M,SARAÇOĞLU Z,Yıldız H,ASLAN A,Sabuncu I "Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis." , ss.37 - 40, 2015.
ISNAD	BİLGİLİ, Memet Erşan vd. "Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis". (2015), 37-40.

APA	BİLGİLİ M, SARAÇOĞLU Z, Yıldız H, ASLAN A, Sabuncu I (2015). Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis. Journal of Clinical and Analytical Medicine, 6(1), 37 - 40.
Chicago	BİLGİLİ Memet Erşan,SARAÇOĞLU Zeynep Nurhan,Yıldız Hamza,ASLAN Abdurrahman,Sabuncu Ilham Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis. Journal of Clinical and Analytical Medicine 6, no.1 (2015): 37 - 40.
MLA	BİLGİLİ Memet Erşan,SARAÇOĞLU Zeynep Nurhan,Yıldız Hamza,ASLAN Abdurrahman,Sabuncu Ilham Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis. Journal of Clinical and Analytical Medicine, vol.6, no.1, 2015, ss.37 - 40.
AMA	BİLGİLİ M,SARAÇOĞLU Z,Yıldız H,ASLAN A,Sabuncu I Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis. Journal of Clinical and Analytical Medicine. 2015; 6(1): 37 - 40.
Vancouver	BİLGİLİ M,SARAÇOĞLU Z,Yıldız H,ASLAN A,Sabuncu I Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis. Journal of Clinical and Analytical Medicine. 2015; 6(1): 37 - 40.
IEEE	BİLGİLİ M,SARAÇOĞLU Z,Yıldız H,ASLAN A,Sabuncu I "Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis." Journal of Clinical and Analytical Medicine, 6, ss.37 - 40, 2015.
ISNAD	BİLGİLİ, Memet Erşan vd. "Comparison of Oral Terbinafine with Itraconazole in the Treatment of Tinea Pedis". Journal of Clinical and Analytical Medicine 6/1 (2015), 37-40.