AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ

ERÇEN DİKEN, Özlem; Demir, Emre; Aydemir, Yusuf

AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ

Özlem ERÇEN DİKEN, (Hitit Üniversitesi Tıp Fakültesi, Göğüs Hastalıları Anabilim Dalı, Çorum)

Yusuf AYDEMİR, (Sakarya Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Sakarya, Türkiye)

Emre DEMİR (Hitit Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı Çorum, Türkiye)

Bozok Tıp Dergisi

4 1

Yıl: 2018 Cilt: 8 Sayı: 1 Sayfa Aralığı: 118 - 124 Metin Dili: Türkçe İndeks Tarihi: 21-01-2019

AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ

Öz:

Amaç: Akciğer kanseri kötü prognozlu ve tedavi yanıtı sınırlı olan bir kanser türüdür. Galektinakciğer kanseri patogenezinde rol alabildiği düşünülen fakat akciğer kanseri ile ilişkisinin yeterlidüzeyde gösterilemediği potansiyel bir belirteçtir. Amacımız serumda basit bir yöntem olan galektin1 ve 3 ölçümünün, akciğer kanseri tanısal ya da prognostik belirteci olup olamayacağınıaraştırmaktır.Yöntem: Çalışmaya 49 akciğer kanseri ve 30 sağlıklı kontrol hastası alındı. Serumlarında galektin1 ve 3 düzeyleri galektin ölçüm kiti ile çalışıldı. Akciğer kanserli olgular ve sağlıklı kontrol hastalarıgalektin 1 ve 3’ün tanısal ve prognostik belirteç olup olmayacağı ile ilgili parametreler istatistikselolarak incelendi.Bulgular: Akciğer kanserli hastada galektin 1 ve 3 değeri, kontrol grubuna göre daha düşüktü.Galektin 1 ve 3 düzeyleri ile sağ kalım, evre ve tümör çapı arasında ilişki saptanmazken, metastazve tümör tipi ile negatif ilişkisi saptandı.Sonuç: Galektin 1 ve 3 değeri akciğer kanseri hastalarında sağlıklı olgulara göre daha düşüktürfakat sensitivite ve spesifitesi kısıtlıdır. Literatürde yüksek galektin düzeyi ile akciğer kanseri arasındapozitif saptanan ilişkinin daha geniş hasta gruplarında çalışılmasının uygun olacağı görüşündeyiz.Basit bir tanısal belirteç olarak serum düzeyinin kullanımı umut vaat etmektedir.

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Solunum Sistemi Hematoloji Onkoloji Gastroenteroloji ve Hepatoloji Pediatri Tıbbi Laboratuar Teknolojisi

Diagnostic and Prognostic Value of Serum Galectin-1 and Galectin-3 Levels in Lung Cancer Patients

Öz:

Objective: Lung cancer is a cancer type with poor prognosis and limited treatment response. Galectin is a potential marker of lung cancer, which is suggested to be involved in the pathogenesis of lung cancer although its association with lung cancer was not accurately demonstrated. Our aim was to investigate whether the simple method of serum galectin 1 and 3 measurements could be diagnostic or prognostic markers of lung cancer. Methods: Forty-nine lung cancer patients and 30 healthy controls were included in the study. The serum galectin 1 and 3 levels were measured using a Galectin assay kit, provided by contribution of the Hitit University Scientific Research Project (SRP). Lung cancer patients and healthy controls were categorized by galectin 1 and 3 levels, either as high or low, and were evaluated statistically for parameters related to diagnostic and prognostic markers. Results: Galectin 1 and 3 values were lower in lung cancer patients compared to the control group (p= 0.015, p= 0.001, respectively). No significant difference was detected for survival and size of tumor between Galectin 1 and 3 groups. Significant difference was detected for metastasis and type of tumor between Galectin 1 and 3 groups. Conclusion: Galectin 1 and 3 values were lower in lung cancer patients compared to healthy subjects but sensitivity and spesifity were not satisfactory. We believe that, the positive relationship between high galectin levels and lung cancer reported in the literature should be assessed further in larger patient populations. Galectin 1 and 3 were not found associated with survival. Measurement of serum galectin-1 and galectin-3 levels as a diagnostic marker is a simple but promising method.

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Solunum Sistemi Hematoloji Onkoloji Gastroenteroloji ve Hepatoloji Pediatri Tıbbi Laboratuar Teknolojisi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ERÇEN DİKEN Ö, Aydemir Y, Demir E (2018). AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ. , 118 - 124.
Chicago	ERÇEN DİKEN Özlem,Aydemir Yusuf,Demir Emre AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ. (2018): 118 - 124.
MLA	ERÇEN DİKEN Özlem,Aydemir Yusuf,Demir Emre AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ. , 2018, ss.118 - 124.
AMA	ERÇEN DİKEN Ö,Aydemir Y,Demir E AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ. . 2018; 118 - 124.
Vancouver	ERÇEN DİKEN Ö,Aydemir Y,Demir E AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ. . 2018; 118 - 124.
IEEE	ERÇEN DİKEN Ö,Aydemir Y,Demir E "AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ." , ss.118 - 124, 2018.
ISNAD	ERÇEN DİKEN, Özlem vd. "AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ". (2018), 118-124.

APA	ERÇEN DİKEN Ö, Aydemir Y, Demir E (2018). AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ. Bozok Tıp Dergisi, 8(1), 118 - 124.
Chicago	ERÇEN DİKEN Özlem,Aydemir Yusuf,Demir Emre AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ. Bozok Tıp Dergisi 8, no.1 (2018): 118 - 124.
MLA	ERÇEN DİKEN Özlem,Aydemir Yusuf,Demir Emre AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ. Bozok Tıp Dergisi, vol.8, no.1, 2018, ss.118 - 124.
AMA	ERÇEN DİKEN Ö,Aydemir Y,Demir E AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ. Bozok Tıp Dergisi. 2018; 8(1): 118 - 124.
Vancouver	ERÇEN DİKEN Ö,Aydemir Y,Demir E AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ. Bozok Tıp Dergisi. 2018; 8(1): 118 - 124.
IEEE	ERÇEN DİKEN Ö,Aydemir Y,Demir E "AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ." Bozok Tıp Dergisi, 8, ss.118 - 124, 2018.
ISNAD	ERÇEN DİKEN, Özlem vd. "AKCİĞER KANSERLİ HASTALARDA SERUM GALEKTİN 1 VE 3 DÜZEYLERİNİN, TANISAL VE PROGNOSTİK DEĞERİ". Bozok Tıp Dergisi 8/1 (2018), 118-124.