TY  - JOUR
TI  - Interleukins As a Marker of Inflammation in Diabetic Foot Syndrome and Type 2 Diabetes Mellitus
AB  - Objective: Diabetic foot ulcers, one of the factors that determine thelife time and quality of life in diabetic patients are one of the mostfrequent causes of hospitalization and surgery. In this study, we aimedto investigate the levels of interleukin (IL)-12 P70, 17, 18, hemoglobin(Hb) A1c, and some parameters in subjects with type 2 diabeticmellitus with diabetic foot and in healthy subjects. Methods: The study was performed on three groups. They werepatients with diabetic foot, with diabetes mellitus type 2 and healthyindividuals (control). IL-12 P70, IL-17, and IL-18, HbA1c levels andother biochemical parameters were compared between three groups.Results: We found higher IL-17, IL-18, white blood cells, glucose andHbA1c in the diabetic group and diabetic foot group than in the controlgroup. IL-12 P70 levels in the diabetic foot group were significantlyhigher than the control group. The performances in diagnosing ofIL-12 P70, 17 and 18 as a biomarker for diabetic foot were foundstatistically significant. IL-12 P70, 17 and 18 levels in diabetic patientswere not different from the levels in patients with diabetic foot.Conclusion: According to our results, IL-12 P70, IL-17 and IL-18 canbe used as biomarkers for diabetic foot. Further studies are needed toshow the role of IL-12 P70, IL-17 and IL-18 levels as a biomarker inchronic inflammatory diseases.
AU  - yazar, hayrullah
AU  - AKDOĞAN, Mehmet
AU  - nalbant, ahmet
AU  - VARIM, Ceyhun
AU  - KALELİ, SÜLEYMAN
DO  - 10.14235/bas.galenos.2017.2077
PY  - 2019
JO  - Bezmiâlem Science
VL  - 7
IS  - 1
SN  - 2148-2373
SP  - 1
EP  - 7
DB  - TRDizin
UR  - http://search/yayin/detay/308063
ER  -