Aim: Although the debate regarding fetal loss and preterm delivery continues, the use of laparoscopic appendectomy (LA) to treatpregnant women has gained legitimacy owing to the advantages it brings, such as less uterine manipulation, less postoperativepain, and an early return to normal daily activity. This present study aims to compare the impact of LA on women in early and lategestation periods with regard to surgical outcomes.Material and Methods: After scanning the files of 4,295 cases, 29 patients who underwent LA for acute appendicitis during pregnancywere enrolled in the study and were assessed retrospectively. The patients were divided into two groups: women with a gestationperiod less than 20 weeks (group 1; n=19) and those over 20 weeks (group 2; n=10). Data from these two groups, including patientperioperative characteristics and morbidity, were compared.Results: The results showed no statistical difference between the two groups. No statistically significant difference was detectedin terms of mean age, body mass index, length of hospital stay, operation time or median ASA score (p > 0.05). Moreover, meanINR (International normalized ratio), hemoglobin, hematocrit, white blood cell count, neutrophil-to-lymphocyte ratio, plateletto-lymphocyte ratio, red cell distribution width, platelet distribution width and histopathological examination of the appendicitisrevealed no statistical difference between the two groups (p > 0.05). Most importantly, comparison of surgical site infection (6.8%),intra-peritoneal collection (3.4%), fetal distress and preterm delivery rate (6.8%), and abortus imminens (3.4%) also showed nosignificant difference (P > 0.05). In this study, no fetal loss was recorded.Conclusion: The results of present study suggest that LA for acute appendicitis in pregnant women can be performed safely duringthe second half of pregnancy.