Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme

Ekerbiçer, Hasan Çetin; Oturak, Gökhan; ASICI, NESE

doi:10.31832/smj.747226

Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme

Neşe Aşıcı, (Sakarya Üniversitesi, Tıp Fakültesi, Halk Sağlığı AD, Sakarya, Türkiye)

Gökhan Oturak, (Sakarya Üniversitesi, Tıp Fakültesi, Halk Sağlığı AD, Sakarya, Türkiye)

Hasan Çetin Ekerbiçer (Sakarya Üniversitesi, Tıp Fakültesi, Halk Sağlığı AD, Sakarya, Türkiye)

Sakarya Tıp Dergisi

29 5

Yıl: 2020 Cilt: 10 Sayı: 2 Sayfa Aralığı: 57 - 68 Metin Dili: Türkçe DOI: 10.31832/smj.747226 İndeks Tarihi: 21-05-2021

Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme

Öz:

Yüksek Fruktozlu Mısır Şurubu (YFMŞ), günümüzde en çok kullanılan ve hakkında en çok tartışılan gıda katkı maddelerinden biridir. Maliyet ucuzluğu, kullanımkolaylığı, sakkaroza göre daha lezzetli olması, tatlılık, kıvam ve renk sağlama avantajları neticesinde 1970’li yıllardan sonra gıda endüstrisinde sakkarozun en büyük rakibiolmuş, 2004 yılına kadar popülaritesi artmış bir üründür. YFMŞ’nin tüketiminin arttığı yılların, obezite prevalansında artışının yaşandığı döneme denk gelmesi, YFMŞ vesağlık üzerine etkileriyle ilgili çalışmaların hız kazanmasına neden olmuştur. YFMŞ özellikle içeriğindeki fruktozun, glukozdan farklı metabolik yolaklar kullanarak vücuttametabolize olması ve bunun neticesinde farklı metabolik etkileri bu endişelerin ana nedenlerinden bazılarıdır. Bu derlemeyi hazırlama amacımız, geçmişten günümüzehala eleştirilen YFMŞ hakkında güncel bilgiler sunmak, özellikle sağlıklı tüketici bilincini geliştirmek amacıyla YFMŞ ve olası olumsuz etkileri hakkında tüketicileribilgilendirmektir.

Anahtar Kelime:

High Fructose Corn Syrup From Past to Present and A Review on Health Efects

Öz:

High fructose corn syrup (HFCS) is one of the most commonly used and most contraversial food additives. Cost-efectivity, usage ease, relatively better taste compared to sucrose, sweetness, consistence and colour advantages made it the biggest rival of sucrose in the food industry afer 1970s and it held its popularity up to 2004. Because the years which HFCS usage have increased, paralleled the increase in obesity, studies focusing on the efects of HFCS on the health have also increased. YFMŞ, especially the metabolism of fructose in the body by using diferent metabolic pathways than glucose and consequently diferent metabolic efects are some of the main causes of these concerns.Te reason we prepare this review is to provıde up to date information on the highly critisized HFCS, develop a healthy consumer opinion and inform the consumers on HFCS and possible negative consequences on the health.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. Ruiz-Matute AI, Weiss M, Sammataro D, Finely J, Sanz ML. Carbohydrate Composition of High-Fructose Corn Syrups (HFCS) Used for Bee Feeding: Ef ect on Honey Composition. J. Agric. Food Chem 2010; 58(12): 7317–7322.
2. Bray GA, Nielsen SJ, Popkin BM. Consumption of High-Fructose Corn Syrup in Beverages may Play a Role in the Epidemic Of Obesity. Am J Clin Nutr 2004;79(4):537–43.
3. Karaoğlu MM. Yüksek Fruktozlu Mısır Şurubu. Gıda Mühendisliği Dergisi 2011;33.
4. Bode JW, Empie MW, Brenner KD. Evolution of High Fructose Corn Syrup Within the Sweeteners Industry. J.M. Rippe (ed.), Fructose, High Fructose Corn Syrup, Sucrose and Health, Nutrition and Health, Chapter 9, ISBN 978-1-4899-8076-2 ISBN 978-1-4899-8077-9 (eBook) DOI 10.1007/978-1-4899-8077-9 Springer New York Heidelberg Dordrecht London, © Springer Science+Business Media New York ;2014.p.137-148.
5. Goran MI, Ulijaszek S, Ventura E. High Fructose Corn Syrup and Diabetes Prevalence: A global perspective. Global Public Health 2013;8(1):55-64.
6. Heiss SN, Bates BR. When a Spoonful of Fallacies Helps the Sweetener Go Down: T e Corn Refiner Association’s Use of Straw-Person Arguments in Health Debates Surrounding High-Fructose Corn Syrup. Health Communıcatıon 2016;31(8): 1029-35.
7. https://www.persistencemarketresearch.com/market-research/high-fructose-corn-syrup-hfcs-market.asp (Erişim Tarihi: 10.5.2020).
8. https://ec.europa.eu/health/sites/health/files/nutrition_physical_activity/docs/2019_sciview_b3_sr_en.pdf (Erişim Tarihi: 10.5.2020).
9. Dillen, K., Dries L, Tolens E. T e mpact of the EU sugar reform on sugar and sugar substitute industries. Working Paper, n° 97, Centre for Agricultural and Food Economics, Katholieke Universiteit Leuven, 2006.
10. https://www.ama-assn.org/sites/ama-assn.org/files/corp/media-browser/public/about-ama/councils/Council%20Reports/council-on-science-public-health/a08-csaph-high-fructose-syrup.pdf (Erişim Tarihi: 10.5.2020).
11. Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzicky P, et al. Endogenous Fructose Production and Metabolism in the Liver Contributes to the Development of Metabolic Syndrome. Nat Commun 2013;4 (Article Number:2434); 1-8.
12. G Ang BR, Yu GF. T e Role of Fructose in Type 2 Diabetes and Other Metabolic Diseases. J Nutr Food Sci 2018;8(1):1-4.
13. Bocarsly ME, Powell ES, Avena NM, Hoebel BG. High-fructose corn syrup causes characteristics of obesity in rats: Increased body weight, body fat and triglyceride levels. Pharmacology, Biochemistry and Behavior 2010;97(1):101–6.
14. Sundborn G, T ornley S, Merriman T, Lang B, King C, Lanaspa MA, et al. Are Liquid Sugars Dif erent from Solid Sugar in T eir Ability to Cause Metabolic Syndrome? Obesity 2019;27(6):879-887.
15. https://corn.org/about-cra/faq/#HFCS (Erişim Tarihi: 10.4.2020).
16. https://www.medscape.com/answers/2087913-163743/what-is-glucose (Erişim Tarihi: 10.4.2020).
17. Yerlikaya A, Dagel T, King C, Kuwabara M, Lanaspa MA, Andres Hernando A, et al. Dietary and commercialized fructose: Sweet or sour? Int Urol Nephrol 2017; 49(9):1611–1620.
18. https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/sweetness (Erişim Tarihi: 10.4.2020).
19. Zargaraan A , Kamaliroosta L , Yaghoubi AS, Mirmoghtadaie L . Ef ect of Substitution of Sugar by High Fructose Corn Syrup on the Physicochemical Properties of Bakery and Dairy Products: A Review. Nutrition and Food Sciences Research 2016;3(4): 3-11.
20. Strober JW, Brady MJ. Dietary Fructose Consumption and Triple-Negative Breast Cancer Incidance. Front Endocrinol (Lausanne) 2019;10(Article367):1-7.
21. Aguirre EK, Mytton OT, Monsivais P. senior university lecturer. Liberalising agricultural policy for sugar in Europe risks damaging public health. BMJ 2015;351:h5085.
22. https://www.who.int/publications/i/item/9789241549028 ( Erişim Tarihi: 10.4.2020).
23. https://www.berkeleywellness.com/healthy-eating/nutrition/article/high-fructose-corn-syrup-worse-regular-sugar ( Erişim Tarihi: 10.4.2020).
24. https://www.turkseker.gov.tr/SECTOR_REPORT.pdf) ( Erişim Tarihi: 12.4.2020).
25. Kroger M, Meister K, Kava R. Low-calorie Sweeteners and Other Sugar Substitutes: A Review of the Safety Issues. Comprehensİve Reviews in Food Science And Food Safety.2006;5:35-47.
26. Parker K, Salas M and Nwosu VC. High fructose corn syrup: Production, uses and public health concerns. Biotechnology and Molecular Biology Review 2010; 5(5):71 – 78.
27. Pepin A , Stanhope KL, Imbeult P. Are Fruit Juices Healthier T an Sugar-Sweetened Beverages? A Review. Nutrients 2019; 11(5):1006.
28. Alibekov RS, Kaiypova AB, Urazbayeva KA , Ortayev AE, Abdugani M. Ef ect of Substitution of Sugar by High Fructose Corn Syrup of the Confıture on the base of Physalis. Periódico Tchê Química 2019; 16:688-697.
29. Özcan S. Modern Dünyanın Vazgeçilmez Bitkisi Mısır: Genetiği Değiştirilmiş (Transgenik) Mısırın Tarımsal Üretime Katkısı. Türk Bilimsel Derlemeler Dergisi 2009; 2(2): 1-34.
30. https://www.healthline.com/nutrition/high-fructose-corn-syrup-vs-sugar#production ( Erişim Tarihi: 12.4.2020).
31. Forshee RA, Storey ML, Allİson DB, Glİnsmann WH, Heİn GL, Lİneback DR, et al. A Critical Examination of the Evidence Relating High Fructose Corn Syrup and Weight Gain. Critical Reviews in Food Science and Nutrition 2007:47(6):561–582.
32. Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, et al. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 2007;86(4):899-906.
33. Moeller SM, Fryhofer SA, Osbahr III AJ, Robinowitz CB & for the Council on Science and Public Health, American Medical Association. T e Ef ects of High Fructose Syrup. Journal of the American College of Nutrition 2009;28 (6):619–626.
34. Kaplan Bulut İ, Mir S. Fruktoz ve böbrek hastalıkları. Cumhuriyet Tıp Dergisi 2011;33(4):499-507.
35. Carvalho CT, Souza MZ, Arbex N, Sa D, Rodrigues LC, Rocha de Sa DA, et al. T e Role of Fructose in Public Health and Obesity. Health 2018; 10(4): 434-41.
36. Dilk A, Savaiano DA. Sugar Price Supports and Taxation. A Public Health Policy Paradox. Nutrition Today 2017;52(3):143-150.
37. https://ec.europa.eu/info/sites/info/files/food-farming-fisheries/farming/documents/agricultural-outlook-report-2015_en.pdf (Erişim Tarihi: 12.4.2020).
38. https://www.isosugar.org/publication/143/quarterly-market-outlook---february-2019 (Erişim Tarihi: 12.4.2020).
39. Arslan Y. Exploring T e Ef ects Of Consumers’ Nutritional Knowledge and Information Interest on the Acceptance of Artificial Sweetener Usage In Sof Drinks. Marketing and Management of Innovations 2019:3;33-44.
40. Vartanian LR, Schwartz MB, Brownell KD. Ef ects of Sof Drink Consumption on Nutrition and Health: A Systematic Review and Meta-Analysis. Am J Public Health 2007;97(4):667- 675.
41. https://www.saglik.gov.tr/EN,32859/ministry-of-health-press-release-scientific-board-report-on-health-impact-of-starch-based-sugars-sbs.html (Erişim Tarihi: 10.4.2020).
42. Le, K A ; Faeh, D ; Stettler, R ; Ith, M ; Kreis, R ; Vermathen, P ; Boesch, C ; Ravussin, E ; Tappy, LA .4-wk high-fructose diet alters lipid metabolism without af ecting insulin sensitivity or ectopic lipids in healthy humans. Am J Clin Nutr 2006;84:1374 –9.
43. Melanson KJ, Zukley L, Lowndes J, Nguyen V, Angelopoulos TJ, Rippe JM. Ef ects of high-fructose corn syrup and sucrose consumption on circulating glucose, insulin, leptin, and ghrelin and on appetite in normal-weight women. Nutrition 2007; 23(2):103–112.
44. Soenen S, Westerterp-Plantenga MS. No dif erences in satiety or energy intake af er high-fructose corn syrup, sucrose, or milk preloads. Am J Clin Nutr 2007;86(6):1586 –94.
45. Angelopoulos TJ, Lowndes J , Sinnett S, Rippe JM. Fructose Containing Sugars at Normal Levels of Consumption Do Not Ef ect Adversely Components of the Metabolic Syndrome and Risk Factors for Cardiovascular Disease. Nutrients 2016;8(4): 179.
46. G Harvey Anderson. Much ado about high-fructose corn syrup in beverages: the meat of the matter. Am J Clin Nutr 2007;86:1577– 8
47. Executive Summary of T e Tird Report of T e National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III) JAMA 2001;16;285(19):2486-97.
48. Elliott SS, Keim N, Ster JS, Tef K, Havel PJ. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 2002;76(5):911–22.
49. Rutledge AC, Adeli K. Fructose and the Metabolic Syndrome: Pathophysiology and Molecular Mechanisms . Nutrition Reviews 2007; 65(6 Pt 2):13-23.
50. https://www.who.int/health-topics/diabetes#tab=tab_1 (Erişim Tarihi: 10.4.2020).
51. Stanhope KL, Schwarz JM,Keim NL, Grif en SJ, Bremer AA, Graham JL. Consuming fructose-sweetened, not glucosesweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 2009;119(5):1322– 34.
52. Imamura F,O’Connor L, Ye Z, Mursu J, Hayashino Y, Bhupathiraju SN. Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction Br J Sports Med 2016;50:496–504.
53. Lin WT, Chan TF, Huang HL, Lee CY, Tsai S, Wu PW, et al. Fructose-Rich Beverage Intake and Central Adiposity, Uric Acid, and Pediatric Insulin Resistance. T e Journal of Pediatrics 2016;171:90-96.e1.
54. https://www.who.int/health-topics/cardiovascular-diseases/#tab=tab_1 (Erişim Tarihi: 10.5.2020).
55. Stanhope KL, Medici V, Bremer AA, Lee V, Lam HD, Nunez MV , et al. A Dose-Response Study Of Consuming High-Fructose Corn Syrup–Sweetened Beverages On Lipid/ Lipoprotein Risk Factors for Cardiovascular Disease in Young Adults. Am J Clin Nutr 2015;101(6):1144–54.
56. Stanhope KL, Bremer AA, Medici V, Nakajima K, Ito Y, Nakano T, et al. Consumption Of Fructose And High Fructose Corn Syrup Increase Postprandial Triglycerides, LDL-Cholesterol, And Apolipoprotein-B İn Young Men And Women. J Clin Endocrinol Metab 2011;96(10):1596–605.
57. Sadowska J, Bruszkowska M. Comparing T e Ef ects Of Sucrose And Hıgh-Fructose Corn Syrup On Lıpıd Metabolısm And T e Rısk Of Cardıovascular Dısease In Male Rats. Acta Sci Pol Technol Aliment 2017;16(2):231–240.
58. De Koning L., Malik, VS., Kellogg MD, Rimm EB., Willett WC, Hu FB. Sweetened Beverage Consumption, Incident Coronary Heart Disease, and Biomarkers of Risk in Men. Circulation 2012;125(14):1735–41.
59. Ross SM. Sugary Drinks A Modifiable Risk Factor for Cancer Prevention. Holist Nurs Pract 2019;33(6):366–369.
60. Mueller NT , Odegaard A, Anderson K, Yuan JM, Gross M, Koh WP, et al.Sof Drink and Juice Consumption and Risk of Pancreatic Cancer: T e Singapore Chinese Health Study. Cancer Epidemiol Biomarkers Prev 2010; 19(2): 447-455.
61. Goncalves MD, Lu C, Tutnauer J, Hartman TE, Hwang SY, Murphy JC, et al. High-fructose corn syrup enhances intestinal tumor growth in mice. Science 2019;363(6433):1345-1349.
62. Kumamoto R , Uto H, Oda K, Ibusuki R , Tanoue S , Arima S, et al. Dietary fructose enhances the incidence of precancerous hepatocytes induced by administration of diethylnitrosamine in rat. European Journal of Medical Research 2013;18:54:1-8.
63. https://www.who.int/news-room/facts-in-pictures/detail/asthma) (Erişim Tarihi: 23.04.2020).
64. Park S, Akinbami LJ, McGuire LC, Blanck HM. Association of sugar-sweetened beverage intake frequency and asthma among U.S. adults, 2013. Preventive Medicine2016; 91: 58–61.
65. DeChristopher LR, Uribarri J, Tucker KL. Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2–9 years. Public Health Nutrition 2016; 19(1):123–130.
66. Vos MB, Lavine JE. Dietary Fructose in Nonalcoholic Fatty Liver Disease. Hepatology 2013;57(6):2525-31.
67. Angulo P. Non-alcoholic fatty liver disease. N Engl J Med 2002; 346(16): 1221-31.
68. Hallfrisch, J. Metabolic ef ects of dietary fructose. T e FASEB Journal 1990;4(9): 2652–60.
69. Mock K , Lateef S, Benedito VA , Toua JC. High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation. Journal of Nutritional Biochemistry 2017;39:32–39.
70. https://www.cdc.gov/arthritis/basics/gout.html (Erişim Tarihi: 23.04.2020).
71. Choi HK, Curhan G. Sof drinks, fructose consumption, and the risk of gout in men: prospective cohort study. BMJ 2008;336(7639):309-312.
72. Nguyen S, MD, Choi HK, Lustig RH, Hsu C. Sugar-Sweetened Beverages, Serum Uric Acid, and Blood Pressure in Adolescents. T e Journal of Pediatrics 2009;154(6):807-813.
73. Wang DD, Sievenpiper JL, de Souza RJ, Chiavaroli L, Ha V, Cozma AI, Mirrahimi A, et al. T e Ef ects of Fructose Intake on Serum Uric Acid Vary among Controlled Dietary Trials. T e Journal of Nutrition 2012;142(5):916-23
74. https://www.who.int/news-room/fact-sheets/detail/sugars-and-dental-caries (Erişim Tarihi: 23.04.2020).
75. Nithya S, Deepika A, Rehman A, Abineeshwar G. Potential metabolic ef ects with use of high-fructose corn syrup in foodstuf s: A review. Drug Invention 2019; 11(1): 156-159.
76. Dufault R, LeBlanc B, Schnoll R, Cornett C, Schweitze R, Wallinga D, Hightower J, et al. Mercury from chlor-alkali plants: measured concentrations in food product sugar . Environmental Health 2009; 8(2):1-6.
77. https://health.gov/sites/default/files/2019-09/2015-2020_Dietary_Guidelines.pdf (Erişim Tarihi: 23.04.2020).
78. Ventura EE, Davis JN, Goran MI. Sugar Content of Popular Sweetened Beverages Based on Objective Laboratory Analysis: Focus on Fructose Content. Obesity (Silver Spring) 2011;19(4):868-74.
79. Jeong D, Kim DH, Oh YT, Song KY, Kim HS, Jhon JW, et al. Fructose Contents of Various Popular Sweetened Beverages based on Milk Using by HPLC. J. Milk Sci.Biotechnol 2017;35(2):99-104.
80. Walker RW, Dumke KA, Goran MI. Fructose content in popular beverages made with and without high-fructose corn syrup. Nutrition 2014;30(7-8):928-35.
81. İçli N, Özkubat Çantay Ö. T e Determination of Usage Prevalance of Corn Syrups in Processed Food Products in Turkey and Health Risks. ACU Sağlık Bil Derg 2019;10(1):78-83.

APA	ASICI N, Oturak G, Ekerbiçer H (2020). Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme. , 57 - 68. 10.31832/smj.747226
Chicago	ASICI NESE,Oturak Gökhan,Ekerbiçer Hasan Çetin Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme. (2020): 57 - 68. 10.31832/smj.747226
MLA	ASICI NESE,Oturak Gökhan,Ekerbiçer Hasan Çetin Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme. , 2020, ss.57 - 68. 10.31832/smj.747226
AMA	ASICI N,Oturak G,Ekerbiçer H Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme. . 2020; 57 - 68. 10.31832/smj.747226
Vancouver	ASICI N,Oturak G,Ekerbiçer H Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme. . 2020; 57 - 68. 10.31832/smj.747226
IEEE	ASICI N,Oturak G,Ekerbiçer H "Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme." , ss.57 - 68, 2020. 10.31832/smj.747226
ISNAD	ASICI, NESE vd. "Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme". (2020), 57-68. https://doi.org/10.31832/smj.747226

APA	ASICI N, Oturak G, Ekerbiçer H (2020). Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme. Sakarya Tıp Dergisi, 10(2), 57 - 68. 10.31832/smj.747226
Chicago	ASICI NESE,Oturak Gökhan,Ekerbiçer Hasan Çetin Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme. Sakarya Tıp Dergisi 10, no.2 (2020): 57 - 68. 10.31832/smj.747226
MLA	ASICI NESE,Oturak Gökhan,Ekerbiçer Hasan Çetin Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme. Sakarya Tıp Dergisi, vol.10, no.2, 2020, ss.57 - 68. 10.31832/smj.747226
AMA	ASICI N,Oturak G,Ekerbiçer H Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme. Sakarya Tıp Dergisi. 2020; 10(2): 57 - 68. 10.31832/smj.747226
Vancouver	ASICI N,Oturak G,Ekerbiçer H Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme. Sakarya Tıp Dergisi. 2020; 10(2): 57 - 68. 10.31832/smj.747226
IEEE	ASICI N,Oturak G,Ekerbiçer H "Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme." Sakarya Tıp Dergisi, 10, ss.57 - 68, 2020. 10.31832/smj.747226
ISNAD	ASICI, NESE vd. "Geçmişten Günümüze Yüksek Fruktozlu Mısır Şurubu ve Sağlık Etkileri Üzerine Bir Derleme". Sakarya Tıp Dergisi 10/2 (2020), 57-68. https://doi.org/10.31832/smj.747226