Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress
Yıl: 2020 Cilt: 31 Sayı: 3 Sayfa Aralığı: 187 - 191 Metin Dili: İngilizce DOI: 10.14744/scie.2020.39205 İndeks Tarihi: 22-05-2021
Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress
Öz: Objective: The purpose of this study is to examine the protective effects of maresin 1 on testicular injury induced by ischemia reperfusion.Methods: 24 Sprague-Dawley male rats were divided into 3 groups. The groups are planned as follows; sham, ischemia reperfusion and ischemia reperfusion+maresin 1 groups. The spermatic cord was detected and clamped for 2 hours to establish the prompt. After 2 hours, the clamp was removed and testicular reperfusion was achieved for 2 hours. At the end of the reperfusion phase, testicular tissues were taken and total antioxidant capacity (TAC), total oxidant capacity (TOC), superoxide dismutase (SOD), malondialdehyde (MDA) and myeloperoxidase (MPO) levels were determined by spectrophotometric method.Results: In the ischemia-reperfusion group, TOS and MDA and MPO are increased, the levels of TAS and SOD molecules are decreased. TOS and SOD levels are increased and TAS, MDA and MPO levels are decreased in the Maresin-1 treatment group.Conclusion: These results show us that a single dose of maresin-1 application is effective against oxidative damage caused by ischemia reperfusion.
Anahtar Kelime: Testiküler İskemi Reperfüzyon ile İndüklenen Oksidatif Strese Maresin-1’in Etkilerinin Araştırılması
Öz: Amaç: Bu araştırmanın amacı, maresin 1'in iskemi reperfüzyonun indüklediği testis hasarı üzerindeki koruyucu etkilerini incelemektir.Gereç ve Yöntem: 24 Sprague-Dawley erkek sıçanlar 3 gruba ayrıldı. Gruplar şu şekilde planlanmıştır; sham, iskemi reperfüzyon ve iskemi reperfüzyon+ maresin 1 grupları. Spermatik kord tespit edildi ve istemi oluşturmak için 2 saat süre ile klempendi. İki saati takiben klemp çıkarıldı ve 2 saat boyunca testis reperfüzyonu sağlandı. Reperfüzyon aşamasının sonunda, testis dokuları alınarak total antioksidan kapasite (TAK), total oksidan kapasite (TOK), süperoksit dismütaz (SOD), malondialdehit (MDA) ve myeloperoksidaz (MPO) düzeyleri spektrofoto-metrik yöntemle belirlendi.Bulgular: İskemi-reperfüzyon grubunda TOS ve MDA ve MPO arttı, TAS ve SOD moleküllerinin seviyeleri azaldı. Maresin-1 tedavi grubunda TOS ve SOD düzeyleri artarken ve TAS, MDA ve MPO düzeyleri azaldı.Sonuç: Bu sonuçlar bize, tek doz maresin-1 uygulamasının, iskemi reperfüzyonunun neden olduğu oksidatif hasara karşı etkili olduğunu göstermiştir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | tanyeli a, Eraslan E, guler m, AKDEMİR F, Güzel Erdoğan D, topdağı ö, polat e (2020). Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress. , 187 - 191. 10.14744/scie.2020.39205 |
| Chicago | tanyeli ayhan,Eraslan Ersen,guler mustafa can,AKDEMİR Fazile Nur EKİNCİ,Güzel Erdoğan Derya,topdağı ömer,polat elif Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress. (2020): 187 - 191. 10.14744/scie.2020.39205 |
| MLA | tanyeli ayhan,Eraslan Ersen,guler mustafa can,AKDEMİR Fazile Nur EKİNCİ,Güzel Erdoğan Derya,topdağı ömer,polat elif Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress. , 2020, ss.187 - 191. 10.14744/scie.2020.39205 |
| AMA | tanyeli a,Eraslan E,guler m,AKDEMİR F,Güzel Erdoğan D,topdağı ö,polat e Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress. . 2020; 187 - 191. 10.14744/scie.2020.39205 |
| Vancouver | tanyeli a,Eraslan E,guler m,AKDEMİR F,Güzel Erdoğan D,topdağı ö,polat e Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress. . 2020; 187 - 191. 10.14744/scie.2020.39205 |
| IEEE | tanyeli a,Eraslan E,guler m,AKDEMİR F,Güzel Erdoğan D,topdağı ö,polat e "Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress." , ss.187 - 191, 2020. 10.14744/scie.2020.39205 |
| ISNAD | tanyeli, ayhan vd. "Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress". (2020), 187-191. https://doi.org/10.14744/scie.2020.39205 |
| APA | tanyeli a, Eraslan E, guler m, AKDEMİR F, Güzel Erdoğan D, topdağı ö, polat e (2020). Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress. Southern Clinics of Istanbul Eurasia, 31(3), 187 - 191. 10.14744/scie.2020.39205 |
| Chicago | tanyeli ayhan,Eraslan Ersen,guler mustafa can,AKDEMİR Fazile Nur EKİNCİ,Güzel Erdoğan Derya,topdağı ömer,polat elif Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress. Southern Clinics of Istanbul Eurasia 31, no.3 (2020): 187 - 191. 10.14744/scie.2020.39205 |
| MLA | tanyeli ayhan,Eraslan Ersen,guler mustafa can,AKDEMİR Fazile Nur EKİNCİ,Güzel Erdoğan Derya,topdağı ömer,polat elif Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress. Southern Clinics of Istanbul Eurasia, vol.31, no.3, 2020, ss.187 - 191. 10.14744/scie.2020.39205 |
| AMA | tanyeli a,Eraslan E,guler m,AKDEMİR F,Güzel Erdoğan D,topdağı ö,polat e Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress. Southern Clinics of Istanbul Eurasia. 2020; 31(3): 187 - 191. 10.14744/scie.2020.39205 |
| Vancouver | tanyeli a,Eraslan E,guler m,AKDEMİR F,Güzel Erdoğan D,topdağı ö,polat e Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress. Southern Clinics of Istanbul Eurasia. 2020; 31(3): 187 - 191. 10.14744/scie.2020.39205 |
| IEEE | tanyeli a,Eraslan E,guler m,AKDEMİR F,Güzel Erdoğan D,topdağı ö,polat e "Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress." Southern Clinics of Istanbul Eurasia, 31, ss.187 - 191, 2020. 10.14744/scie.2020.39205 |
| ISNAD | tanyeli, ayhan vd. "Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress". Southern Clinics of Istanbul Eurasia 31/3 (2020), 187-191. https://doi.org/10.14744/scie.2020.39205 |
