Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases

Varım, Ceyhun; Cengiz, Hasret; Demirci, Taner; DEMİRCİ, ayşe; Meral, Büşra; ŞENOCAK, İLYAS ETHEM

doi:10.31832/smj.739343

Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases

Taner Demirci, (Sakarya Üniversitesi Araştırma ve Eğitim Hastanesi Endokrinoloji ve Metabolizma Kliniği, Sakarya, Türkiye)

Ceyhun Varım, (Sakarya Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, Sakarya, Türkiye)

Hasret Cengiz, (Sakarya Üniversitesi Araştırma ve Eğitim Hastanesi Endokrinoloji ve Metabolizma Kliniği, Sakarya, Türkiye)

Büşra Meral, (Sakarya Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, Sakarya, Türkiye)

İlyas Ethem Şenocak, (Sakarya Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı, Sakarya, Türkiye)

Ayşe Demirci (Sakarya Üniversitesi Araştırma ve Eğitim Hastanesi, Tıbbi Onkoloji Kliniği, Sakarya, Türkiye)

Sakarya Tıp Dergisi

5 0

Yıl: 2020 Cilt: 10 Sayı: 3 Sayfa Aralığı: 484 - 489 Metin Dili: İngilizce DOI: 10.31832/smj.739343 İndeks Tarihi: 23-05-2021

Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases

Öz:

Objective Adrenal incidentaloma (AI) are randomly detected masses in magnetic resonance imaging (MRI) or computed tomography (CT) scans taken for different reasons.Although AI is not generally known as an inflammatory clinical condition, its proinflammatory properties have been demonstrated. In this study, we aimed to investigatethe relationship between AI and neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) and its clinical significance.Materialsand MethodsA total of 178 patients who were followed up in the Endocrinology clinic due to AI between January 2018 and December 2019 were retrospectively screened and analyzed.Results The median of NLR and PLR (IQR; 25%-75%) values were 2.21 (1.61; 1.58-3.2) and 112.56 (57.31; 87.81-145.12), respectively. According to tumor locations, median NLR(IQR; 25% -75%) values were 2.24 (1.72; 1.52-3.22) in right-sided AIs, 2.08 (1.14; 1.63-2.77) in left-sided AIs and 2.49 (2.61;1.52-4.13) in bilateral AIs, and no statisticallysignificant difference was found (p=0.172). Likewise, the PLR median (IQR; 25%-75%) was 116.18 (61.1; 88.25-149.35) in right-sided AIs, 102.87 (52.76; 85.01-137.77) inleft-sided AIs and 126.88 (66.7; 95.06-161.76) in bilateral, with no statistically significant difference (p=0.158). There was no statistically significant difference in NLR andPLR in regard of functionally (p=0.357 and p=0.174, respectively). In addition, NLR and PLR results were compared according to presence of hypertension (HT) and nodifference was found (p=0.10 for NLR, p=0.32 for PLR). Of the factors examined in relation to hemogram parameters, only tumor size had a positive but low correlationwith NLR (r=0.199, p=0,01).Conclusion In this study, we found that NLR and PLR did not increase statistically significantly in AI patients. However, there was a positive correlation between tumor size and NLR.It is concluded that although inflammatory hemogram parameters are inexpensive and easily accessible in general, there is no clinical significance in AI patients.

Anahtar Kelime:

Adrenal Incidentaloma Olgularında Hemogram Parametrelerinin Değerlendirilmesi ve Klinik Önemi

Öz:

Amaç Adrenal insidentaloma (AI), manyetik rezonans görüntüleme (MRI) veya bilgisayarlı tomografi (BT) taramalarında farklı nedenlerle rastgele saptanan kitlelerdir. AI inflamatuar bir klinik durum değildir fakat proinflamatuvar özellikleri gösterilmiştir. Biz bu çalışmada AI ile nötrofil-lenfosit oranı (NLR) ve trombosit-lenfosit oranı (PLR) arasındaki ilişkiyi ve bu oranların klinik önemini ortaya koymaya çalıştık. Gereç ve Yöntemler Ocak 2018 - Aralık 2019 tarihleri arasında AI nedeniyle Endokrinoloji kliniğinde takip ettiğimiz toplam 178 hasta retrospektif olarak tarandı. Bulgular NLR ve PLR medyan (IQR; % 25-75) değerleri sırasıyla 2.21 (1.61; 1.58-3.2) ve 112.56 (57.31; 87.81-145.12) idi. Tümör yerleşimlerine göre; NLR medyan (IQR; % 25-75) değerleri; sağ taraflı 2.24 (1.72; 1.52-3.22), sol taraflı 2.08 (1.14; 1.63-2.77) ve bilateral 2.49 (2.61; 1.52- 4.13) olarak saptandı ve istatistiksel olarak anlamlı bir fark bulunmadı (p = 0.172). Benzer şekilde, PLR medyan (IQR; % 25-75) değerleri; sağ taraflı 116.18 (61.1; 88.25-149.35), sol taraflı 102.87 (52.76; 85.01-137.77) ve bilateral 126.88 (66.7; 95.06-161.76) olarak saptandı ve istatistiksel olarak anlamlı bir fark bulunmadı (p = 0.158). Fonksiyonel AI’lar ve non-fonksiyonel AI’lar karşılaştırıldığında NLR ve PLR açısından istatistiksel olarak anlamlı bir fark yoktu (sırasıyla p = 0.357 ve p = 0.174). Ek olarak, NLR ve PLR sonuçları hipertansiyon (HT) varlığına göre karşılaştırıldı ve fark bulunmadı (NLR için p = 0.10, PLR için p = 0.32). Hemogram parametreleriyle ilişkili olarak incelenen faktörlerden sadece tümör büyüklüğü NLR ile düşük fakat pozitif korelasyon gösterdi (r = 0.199, p = 0,01). Sonuç Bu çalışmada AI hastalarında NLR ve PLR’nin istatistiksel olarak anlamlı bir şekilde artmadığını saptadık. Ancak tümör boyutu ile NLR arasında pozitif korelasyon olduğu tespit edilmiştir. Genel olarak inflamatuvar hemogram parametrelerinin ucuz ve kolay ulaşılabilir olmasına rağmen AI hastalarında klinik bir öneminin olmadığı sonucuna varılmıştır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Demirci T, Varım C, Cengiz H, Meral B, ŞENOCAK İ, DEMİRCİ a (2020). Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases. , 484 - 489. 10.31832/smj.739343
Chicago	Demirci Taner,Varım Ceyhun,Cengiz Hasret,Meral Büşra,ŞENOCAK İLYAS ETHEM,DEMİRCİ ayşe Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases. (2020): 484 - 489. 10.31832/smj.739343
MLA	Demirci Taner,Varım Ceyhun,Cengiz Hasret,Meral Büşra,ŞENOCAK İLYAS ETHEM,DEMİRCİ ayşe Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases. , 2020, ss.484 - 489. 10.31832/smj.739343
AMA	Demirci T,Varım C,Cengiz H,Meral B,ŞENOCAK İ,DEMİRCİ a Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases. . 2020; 484 - 489. 10.31832/smj.739343
Vancouver	Demirci T,Varım C,Cengiz H,Meral B,ŞENOCAK İ,DEMİRCİ a Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases. . 2020; 484 - 489. 10.31832/smj.739343
IEEE	Demirci T,Varım C,Cengiz H,Meral B,ŞENOCAK İ,DEMİRCİ a "Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases." , ss.484 - 489, 2020. 10.31832/smj.739343
ISNAD	Demirci, Taner vd. "Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases". (2020), 484-489. https://doi.org/10.31832/smj.739343

APA	Demirci T, Varım C, Cengiz H, Meral B, ŞENOCAK İ, DEMİRCİ a (2020). Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases. Sakarya Tıp Dergisi, 10(3), 484 - 489. 10.31832/smj.739343
Chicago	Demirci Taner,Varım Ceyhun,Cengiz Hasret,Meral Büşra,ŞENOCAK İLYAS ETHEM,DEMİRCİ ayşe Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases. Sakarya Tıp Dergisi 10, no.3 (2020): 484 - 489. 10.31832/smj.739343
MLA	Demirci Taner,Varım Ceyhun,Cengiz Hasret,Meral Büşra,ŞENOCAK İLYAS ETHEM,DEMİRCİ ayşe Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases. Sakarya Tıp Dergisi, vol.10, no.3, 2020, ss.484 - 489. 10.31832/smj.739343
AMA	Demirci T,Varım C,Cengiz H,Meral B,ŞENOCAK İ,DEMİRCİ a Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases. Sakarya Tıp Dergisi. 2020; 10(3): 484 - 489. 10.31832/smj.739343
Vancouver	Demirci T,Varım C,Cengiz H,Meral B,ŞENOCAK İ,DEMİRCİ a Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases. Sakarya Tıp Dergisi. 2020; 10(3): 484 - 489. 10.31832/smj.739343
IEEE	Demirci T,Varım C,Cengiz H,Meral B,ŞENOCAK İ,DEMİRCİ a "Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases." Sakarya Tıp Dergisi, 10, ss.484 - 489, 2020. 10.31832/smj.739343
ISNAD	Demirci, Taner vd. "Evaluation and Clinical Significance of Hemogram Parameters in Adrenal Incidentaloma Cases". Sakarya Tıp Dergisi 10/3 (2020), 484-489. https://doi.org/10.31832/smj.739343