Throughout history, human beings have lived to survive, have struggled to have a job and haveenough income for a better life. But at the point we have reached today, people's quality of lifenot only depends on wealth and employment but also on many subjective factors, including theconditions of the environment in which they live, physical and mental health, education,recreation, security, leisure, freedom, human rights, social belonging and happiness level.Although this situation is related to the individuals at the micro scale, it is one of the importantfocal points of central and local governments on the macro scale. For administrators, revealingregional differences in well-being is an important criterion for eliminating social inequalities.There are many different multi-criteria decision making based studies that calculated the indexof quality of life in 81 provinces of Turkey following 11 dimensions and 41 indicatorsdetermined by Turkstat. This study aims to compare the quality of life studies and rankings ofcities based on six different statistical methods. GIS-based IDW interpolation technique wasused to understand the spatial distribution of the well-being index and make an accuratecomparison of the calculation methodologies. As a result of the study, it was seen that differentmethods performed on the same data gave very different results from each other.