The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience

Yıl: 2021 Cilt: 13 Sayı: 1 Sayfa Aralığı: 4 - 10 Metin Dili: İngilizce DOI: 10.18521/ktd.841747 İndeks Tarihi: 27-06-2021

The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience

Öz:
Objective: The aim of this study was to investigate the efficacy of favipiravir (FVP) in severe COVID-19.Methods: This is a retrospective study of 142 COVID-19 patients with severe pneumonia signs, who received inpatient treatment between March 15 and May 20, 2020. The patients were divided into two groups according to the use of FVP treatment; group 1 (n = 99) included patients who treated with FVP and group 2 (n = 43) who didn’t receive FVP.Results: Mean age was 66.47 ± 11.89 in group 1, and 68.58 ± 14.78 in group 2. Forty patients (40.4%) in group 1 and 22 (51.2%) in group 2 were treated in the intensive care unit (P > 0.05). The proportion of eosinophil, tendency of increasing thrombocyte counts and eosinophil/neutrophil ratio in FVP group was significantly higher than non-FVP group (p < 0.05). In Group 1, patients had significantly reduced erythroid series, and elevated uric acid levels as side effects of FVP. With respect to complications during hospitalization, there was no significant difference among the groups for mechanical ventilator requirement, acute kidney injury, dialysis requirement and sepsis (P > 0.05). The mortality rates in Group 1 (n = 26 [26.3%]) were lower than those in group 2 (n = 16 [37.2%]), but it was not statistically significant.Conclusions: While the treatment of COVID-19 pneumonia options were limited during the initial stages of the pandemic, the FVP may be effective in severe cases. To confirm this effect, randomized controlled studies are needed in patients of all disease severities.
Anahtar Kelime:

Şiddetli COVID-19 Pnömonisinde Favipiravir Tedavisinin Etkinliği: Tek Merkez Deneyimi

Öz:
Amaç: Çalışmamızda, şiddetli COVID-19'da favipiravirin (FVP) etkinliğiniaraştırmak amaçlandı. Gereç ve Yöntem: 15 Mart - 20 Mayıs 2020 tarihleri arasında yatarak tedavi gören,ağır pnömoni belirtileri olan 142 COVID-19 hastası retrospektif olarak analiz edildi.Hastalar FVP tedavisinin kullanımına göre iki gruba ayrıldı; grup 1 (n = 99) FVP iletedavi edilen hastaları ve grup 2 FVP tedavisi almayan hastaları içeriyordu.Bulgular: Grup 1'de ortalama yaş 66,47 ± 11,89, grup 2'de 68,58 ± 14,78 idi. Grup1'de 40 hasta (% 40,4) ve grup 2'de 22 (% 51,2) yoğun bakım ünitesinde tedavi edildi(P> 0,05) . FVP tedavi grubunda eozinofil düzeyi, trombosit sayısı ve eozinofil /nötrofil oranı FVP tedvisi almayan gruba göre anlamlı olarak yüksek bulundu (p<0.05). Grup 1'de hastalarda FVP'nin yan etkileri olarak eritroid serileri önemli ölçüdeazalmış ve ürik asit seviyeleri yükselmiştir. Hastanede yatış sırasındakikomplikasyonlar açısından mekanik ventilatör ihtiyacı, akut böbrek hasarı, diyalizgereksinimi ve sepsis açısından gruplar arasında anlamlı fark yoktu (P> 0.05). Grup1'deki mortalite oranları (n = 26 [% 26.3]), grup 2” deki hastalardan (n = 16 [% 37.2])daha düşüktü, ancak istatistiksel olarak anlamlı değildi. Sonuç: COVID-19 pnömonisinde tedavi seçenekleri pandeminin ilk aşamalarındasınırlı iken, ciddi vakalarda FVP etkili olabilir. Bu etkiyi doğrulamak için, tümhastalık şiddetlerindeki hastalarda randomize kontrollü çalışmalara ihtiyaç vardır.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA dheir h, YAYLACI S, Sipahi S, Şenocak D, toptan h, ASICI N, Demirci T, TOCOĞLU A, kocayiğit h, Aydemir Y, salihi s, Firat N, KARABAY O (2021). The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience. , 4 - 10. 10.18521/ktd.841747
Chicago dheir hamad,YAYLACI SELÇUK,Sipahi Savaş,Şenocak Didar,toptan hande,ASICI NESE,Demirci Taner,TOCOĞLU Aysel,kocayiğit havva,Aydemir Yusuf,salihi salih,Firat Necattin,KARABAY OĞUZ The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience. (2021): 4 - 10. 10.18521/ktd.841747
MLA dheir hamad,YAYLACI SELÇUK,Sipahi Savaş,Şenocak Didar,toptan hande,ASICI NESE,Demirci Taner,TOCOĞLU Aysel,kocayiğit havva,Aydemir Yusuf,salihi salih,Firat Necattin,KARABAY OĞUZ The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience. , 2021, ss.4 - 10. 10.18521/ktd.841747
AMA dheir h,YAYLACI S,Sipahi S,Şenocak D,toptan h,ASICI N,Demirci T,TOCOĞLU A,kocayiğit h,Aydemir Y,salihi s,Firat N,KARABAY O The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience. . 2021; 4 - 10. 10.18521/ktd.841747
Vancouver dheir h,YAYLACI S,Sipahi S,Şenocak D,toptan h,ASICI N,Demirci T,TOCOĞLU A,kocayiğit h,Aydemir Y,salihi s,Firat N,KARABAY O The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience. . 2021; 4 - 10. 10.18521/ktd.841747
IEEE dheir h,YAYLACI S,Sipahi S,Şenocak D,toptan h,ASICI N,Demirci T,TOCOĞLU A,kocayiğit h,Aydemir Y,salihi s,Firat N,KARABAY O "The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience." , ss.4 - 10, 2021. 10.18521/ktd.841747
ISNAD dheir, hamad vd. "The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience". (2021), 4-10. https://doi.org/10.18521/ktd.841747
APA dheir h, YAYLACI S, Sipahi S, Şenocak D, toptan h, ASICI N, Demirci T, TOCOĞLU A, kocayiğit h, Aydemir Y, salihi s, Firat N, KARABAY O (2021). The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience. KONURALP TIP DERGİSİ, 13(1), 4 - 10. 10.18521/ktd.841747
Chicago dheir hamad,YAYLACI SELÇUK,Sipahi Savaş,Şenocak Didar,toptan hande,ASICI NESE,Demirci Taner,TOCOĞLU Aysel,kocayiğit havva,Aydemir Yusuf,salihi salih,Firat Necattin,KARABAY OĞUZ The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience. KONURALP TIP DERGİSİ 13, no.1 (2021): 4 - 10. 10.18521/ktd.841747
MLA dheir hamad,YAYLACI SELÇUK,Sipahi Savaş,Şenocak Didar,toptan hande,ASICI NESE,Demirci Taner,TOCOĞLU Aysel,kocayiğit havva,Aydemir Yusuf,salihi salih,Firat Necattin,KARABAY OĞUZ The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience. KONURALP TIP DERGİSİ, vol.13, no.1, 2021, ss.4 - 10. 10.18521/ktd.841747
AMA dheir h,YAYLACI S,Sipahi S,Şenocak D,toptan h,ASICI N,Demirci T,TOCOĞLU A,kocayiğit h,Aydemir Y,salihi s,Firat N,KARABAY O The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience. KONURALP TIP DERGİSİ. 2021; 13(1): 4 - 10. 10.18521/ktd.841747
Vancouver dheir h,YAYLACI S,Sipahi S,Şenocak D,toptan h,ASICI N,Demirci T,TOCOĞLU A,kocayiğit h,Aydemir Y,salihi s,Firat N,KARABAY O The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience. KONURALP TIP DERGİSİ. 2021; 13(1): 4 - 10. 10.18521/ktd.841747
IEEE dheir h,YAYLACI S,Sipahi S,Şenocak D,toptan h,ASICI N,Demirci T,TOCOĞLU A,kocayiğit h,Aydemir Y,salihi s,Firat N,KARABAY O "The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience." KONURALP TIP DERGİSİ, 13, ss.4 - 10, 2021. 10.18521/ktd.841747
ISNAD dheir, hamad vd. "The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience". KONURALP TIP DERGİSİ 13/1 (2021), 4-10. https://doi.org/10.18521/ktd.841747