TY  - JOUR
TI  - The Effectiveness of Favipiravir Treatment in Severe COVID-19 Pneumonia: a Single Centre Experience
AB  - Objective: The aim of this study was to investigate the efficacy of favipiravir (FVP) in severe COVID-19.Methods: This is a retrospective study of 142 COVID-19 patients with severe pneumonia signs, who received inpatient treatment between March 15 and May 20, 2020. The patients were divided into two groups according to the use of FVP treatment; group 1 (n = 99) included patients who treated with FVP and group 2 (n = 43) who didn’t receive FVP.Results: Mean age was 66.47 ± 11.89 in group 1, and 68.58 ± 14.78 in group 2. Forty patients (40.4%) in group 1 and 22 (51.2%) in group 2 were treated in the intensive care unit (P > 0.05). The proportion of eosinophil, tendency of increasing thrombocyte counts and eosinophil/neutrophil ratio in FVP group was significantly higher than non-FVP group (p < 0.05). In Group 1, patients had significantly reduced erythroid series, and elevated uric acid levels as side effects of FVP. With respect to complications during hospitalization, there was no significant difference among the groups for mechanical ventilator requirement, acute kidney injury, dialysis requirement and sepsis (P > 0.05). The mortality rates in Group 1 (n = 26 [26.3%]) were lower than those in group 2 (n = 16 [37.2%]), but it was not statistically significant.Conclusions: While the treatment of COVID-19 pneumonia options were limited during the initial stages of the pandemic, the FVP may be effective in severe cases. To confirm this effect, randomized controlled studies are needed in patients of all disease severities.
AU  - ASICI, NESE
AU  - Firat, Necattin
AU  - Şenocak, Didar
AU  - Aydemir, Yusuf
AU  - YAYLACI, SELÇUK
AU  - Sipahi, Savaş
AU  - kocayiğit, havva
AU  - toptan, hande
AU  - salihi, salih
AU  - dheir, hamad
AU  - Demirci, Taner
AU  - TOCOĞLU, Aysel
AU  - KARABAY, OĞUZ
DO  - 10.18521/ktd.841747
PY  - 2021
JO  - KONURALP TIP DERGİSİ
VL  - 13
IS  - 1
SN  - 1309-3878
SP  - 4
EP  - 10
DB  - TRDizin
UR  - http://search/yayin/detay/427808
ER  -