Yıl: 2021 Cilt: 51 Sayı: 2 Sayfa Aralığı: 428 - 434 Metin Dili: İngilizce DOI: 10.3906/sag-2007-260 İndeks Tarihi: 20-01-2022

Clinical course of COVID-19 disease in immunosuppressed renal transplant patients

Öz:
Background/aim: We aimed to identify clinical settings of renal transplant patients with COVID-19. Materials and methods: In this retrospective study, we included kidney transplant inpatients with laboratory confirmed COVID-19 who had been discharged or had died by October 1st, 2020. Characteristics of the patients, including basal and last outpatient biochemical parameters were recorded. Discontinuation or dosage reduction of immunosuppressives and other treatment information was documented. Results: Twenty patients were included in this study, of whom 18 were discharged and 2 died in hospital. The mean duration of hospitalization and follow-up were 9.7 ± 6.4 days and 4.5 ± 2.0 months, respectively. Fourteen patients (70%) were male and mean age was 48.0 ± 10.3 years. At admission, all had immunosuppression withdrawn and were started on methylprednisolone 16 mg/ day (50%) or dexamethasone (50%). Tacrolimus/m-TOR inhibitors were reduced by 50% and all antimetabolites were discontinued. Hemodialysis was needed for 10% of patients. Acute kidney injury was detected in 25% of the patients. With respect to hospitalization time and complications, there was no significant difference between patients who used dexamethasone and those who did not (P > 0.05). The discontinued immunosuppressives were resumed within 2 to 4 weeks after discharge according to the severity of disease. No rehospitalization or acute rejection was detected during the follow-up of the patients.Conclusion: Renal transplant patients are considered a high risk group for COVID-19. It can be said that discontinuation or reducing dosages of immunosuppressives may be effective and safe in kidney transplant patients.Key words: COVID-19, SARS-CoV-2, kidney transplantation, immunosuppression, mortality, acute rejection
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APA dheir h, SİPAHİ S, YAYLACI S, ÇETİN E, Genc A, Firat N, Koroglu M, Muratdağı G, tomak y, ÖZMEN SÜNER K, Ateş Ö, KARABAY O (2021). Clinical course of COVID-19 disease in immunosuppressed renal transplant patients. , 428 - 434. 10.3906/sag-2007-260
Chicago dheir hamad,SİPAHİ Savaş,YAYLACI SELÇUK,ÇETİN Esma Seda,Genc Ahmed Bilal,Firat Necattin,Koroglu Mehmet,Muratdağı Gürkan,tomak yakup,ÖZMEN SÜNER KEZBAN,Ateş Ömer Faruk,KARABAY OĞUZ Clinical course of COVID-19 disease in immunosuppressed renal transplant patients. (2021): 428 - 434. 10.3906/sag-2007-260
MLA dheir hamad,SİPAHİ Savaş,YAYLACI SELÇUK,ÇETİN Esma Seda,Genc Ahmed Bilal,Firat Necattin,Koroglu Mehmet,Muratdağı Gürkan,tomak yakup,ÖZMEN SÜNER KEZBAN,Ateş Ömer Faruk,KARABAY OĞUZ Clinical course of COVID-19 disease in immunosuppressed renal transplant patients. , 2021, ss.428 - 434. 10.3906/sag-2007-260
AMA dheir h,SİPAHİ S,YAYLACI S,ÇETİN E,Genc A,Firat N,Koroglu M,Muratdağı G,tomak y,ÖZMEN SÜNER K,Ateş Ö,KARABAY O Clinical course of COVID-19 disease in immunosuppressed renal transplant patients. . 2021; 428 - 434. 10.3906/sag-2007-260
Vancouver dheir h,SİPAHİ S,YAYLACI S,ÇETİN E,Genc A,Firat N,Koroglu M,Muratdağı G,tomak y,ÖZMEN SÜNER K,Ateş Ö,KARABAY O Clinical course of COVID-19 disease in immunosuppressed renal transplant patients. . 2021; 428 - 434. 10.3906/sag-2007-260
IEEE dheir h,SİPAHİ S,YAYLACI S,ÇETİN E,Genc A,Firat N,Koroglu M,Muratdağı G,tomak y,ÖZMEN SÜNER K,Ateş Ö,KARABAY O "Clinical course of COVID-19 disease in immunosuppressed renal transplant patients." , ss.428 - 434, 2021. 10.3906/sag-2007-260
ISNAD dheir, hamad vd. "Clinical course of COVID-19 disease in immunosuppressed renal transplant patients". (2021), 428-434. https://doi.org/10.3906/sag-2007-260
APA dheir h, SİPAHİ S, YAYLACI S, ÇETİN E, Genc A, Firat N, Koroglu M, Muratdağı G, tomak y, ÖZMEN SÜNER K, Ateş Ö, KARABAY O (2021). Clinical course of COVID-19 disease in immunosuppressed renal transplant patients. Turkish Journal of Medical Sciences, 51(2), 428 - 434. 10.3906/sag-2007-260
Chicago dheir hamad,SİPAHİ Savaş,YAYLACI SELÇUK,ÇETİN Esma Seda,Genc Ahmed Bilal,Firat Necattin,Koroglu Mehmet,Muratdağı Gürkan,tomak yakup,ÖZMEN SÜNER KEZBAN,Ateş Ömer Faruk,KARABAY OĞUZ Clinical course of COVID-19 disease in immunosuppressed renal transplant patients. Turkish Journal of Medical Sciences 51, no.2 (2021): 428 - 434. 10.3906/sag-2007-260
MLA dheir hamad,SİPAHİ Savaş,YAYLACI SELÇUK,ÇETİN Esma Seda,Genc Ahmed Bilal,Firat Necattin,Koroglu Mehmet,Muratdağı Gürkan,tomak yakup,ÖZMEN SÜNER KEZBAN,Ateş Ömer Faruk,KARABAY OĞUZ Clinical course of COVID-19 disease in immunosuppressed renal transplant patients. Turkish Journal of Medical Sciences, vol.51, no.2, 2021, ss.428 - 434. 10.3906/sag-2007-260
AMA dheir h,SİPAHİ S,YAYLACI S,ÇETİN E,Genc A,Firat N,Koroglu M,Muratdağı G,tomak y,ÖZMEN SÜNER K,Ateş Ö,KARABAY O Clinical course of COVID-19 disease in immunosuppressed renal transplant patients. Turkish Journal of Medical Sciences. 2021; 51(2): 428 - 434. 10.3906/sag-2007-260
Vancouver dheir h,SİPAHİ S,YAYLACI S,ÇETİN E,Genc A,Firat N,Koroglu M,Muratdağı G,tomak y,ÖZMEN SÜNER K,Ateş Ö,KARABAY O Clinical course of COVID-19 disease in immunosuppressed renal transplant patients. Turkish Journal of Medical Sciences. 2021; 51(2): 428 - 434. 10.3906/sag-2007-260
IEEE dheir h,SİPAHİ S,YAYLACI S,ÇETİN E,Genc A,Firat N,Koroglu M,Muratdağı G,tomak y,ÖZMEN SÜNER K,Ateş Ö,KARABAY O "Clinical course of COVID-19 disease in immunosuppressed renal transplant patients." Turkish Journal of Medical Sciences, 51, ss.428 - 434, 2021. 10.3906/sag-2007-260
ISNAD dheir, hamad vd. "Clinical course of COVID-19 disease in immunosuppressed renal transplant patients". Turkish Journal of Medical Sciences 51/2 (2021), 428-434. https://doi.org/10.3906/sag-2007-260