Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation

Dinç, Erdal; ÖZDEMİR, Abdil; ONUR, Feyyaz

Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation

Abdil ÖZDEMİR, (Sakarya Üniversitesi, Fen Edebiyat Fakültesi, Kimya Anabilim Dalı, Sakarya, Türkiye)

Erdal DİNÇ, (Ankara Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalı, Ankara, Türkiye)

Feyyaz ONUR (Ankara Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalı, Ankara, Türkiye)

Turkish Journal of Pharmaceutical Sciences

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Yıl: 2004 Cilt: 1 Sayı: 3 Sayfa Aralığı: 139 - 151 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation

Öz:

Bu çalışmada, iki kemometrik teknik, klasik en küçük kareler (CLS) ve ters en küçük kareler (ILS)i parasetamol , aspirin ve kafein’in üçlü karışımı halindeyken aynı anda UV sıfırıncı derece ve türev spektrofotometrik miktar tayinleri için uygulanmıştır. Bu kemometrik kalibrasyonlar; hem sıfırıncı derece hem de birinci derece türev spektrumlarında absorbanslar ve dA/d$lambda$ değerleri 210-305 nm aralığındaki spektrumda okunarak 0.1M HCL içerisinde 5–25$mu$g/ml parasetamol , 5–25 $mu$g/ml aspirin and 4–28 $mu$g/ml kafein içeren çalışma seti için hazırlanmıştır. Kemometrik kalibrasyonlar bu etken maddeleri içeren sentetik karışımlara uygulanarak yöntemin geçerliği gösterilmiştir. Önerilen teknikler bu üç etken maddeyi içeren bir preparata uygulanmış ve elde edilen sonuçlar istatistiksel olarak birbirleriyle karşılaştırılmıştır.

Anahtar Kelime: Aspirin Kalibrasyon Asetaminofen Spektrofotometri Kafein

Konular: Farmakoloji ve Eczacılık

Bir farmasötik preparatta parasetamol aspirin ve kafeinin aynı anda spektrofotometrik miktar tayinleri için çok değişkenli kalibrasyon tekniklerinin kullanılışı

Öz:

Two chemometric techniques, classical least squares (CLS) and inverse least squares (ILS) were applied to UV zero-order and derivative spectrophotometric determination of paracetamol , aspirin and caffeine in their ternary mixture. These chemometric calibrations for both zero-order and first derivative spectra were constructed by measuring the absorbance and dA/d$lambda$ values at full spectral points in the wavelength range 210–305 nm for a training set containing 5–25$mu$g/ml paracetamol , 5–25 $mu$g/ml aspirin and 4–28 $mu$g/ml caffeine in 0.1M HCL. The chemometric calibrations were validated by using the synthetic mixtures containing these drugs. Proposed techniques were applied to a pharmaceutical preparation containing these three active ingredients and the results were statistically compared with each other.

Anahtar Kelime: Caffeine Aspirin Calibration Acetaminophen Spectrophotometry

Konular: Farmakoloji ve Eczacılık

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZDEMİR A, Dinç E, ONUR F (2004). Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation. , 139 - 151.
Chicago	ÖZDEMİR Abdil,Dinç Erdal,ONUR Feyyaz Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation. (2004): 139 - 151.
MLA	ÖZDEMİR Abdil,Dinç Erdal,ONUR Feyyaz Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation. , 2004, ss.139 - 151.
AMA	ÖZDEMİR A,Dinç E,ONUR F Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation. . 2004; 139 - 151.
Vancouver	ÖZDEMİR A,Dinç E,ONUR F Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation. . 2004; 139 - 151.
IEEE	ÖZDEMİR A,Dinç E,ONUR F "Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation." , ss.139 - 151, 2004.
ISNAD	ÖZDEMİR, Abdil vd. "Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation". (2004), 139-151.

APA	ÖZDEMİR A, Dinç E, ONUR F (2004). Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation. Turkish Journal of Pharmaceutical Sciences, 1(3), 139 - 151.
Chicago	ÖZDEMİR Abdil,Dinç Erdal,ONUR Feyyaz Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation. Turkish Journal of Pharmaceutical Sciences 1, no.3 (2004): 139 - 151.
MLA	ÖZDEMİR Abdil,Dinç Erdal,ONUR Feyyaz Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation. Turkish Journal of Pharmaceutical Sciences, vol.1, no.3, 2004, ss.139 - 151.
AMA	ÖZDEMİR A,Dinç E,ONUR F Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation. Turkish Journal of Pharmaceutical Sciences. 2004; 1(3): 139 - 151.
Vancouver	ÖZDEMİR A,Dinç E,ONUR F Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation. Turkish Journal of Pharmaceutical Sciences. 2004; 1(3): 139 - 151.
IEEE	ÖZDEMİR A,Dinç E,ONUR F "Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation." Turkish Journal of Pharmaceutical Sciences, 1, ss.139 - 151, 2004.
ISNAD	ÖZDEMİR, Abdil vd. "Utilization of multivariate calibration techniques for the spectrophotometric simultaneous determination of paracetamol, aspirin and caffeine in a pharmaceutical formulation". Turkish Journal of Pharmaceutical Sciences 1/3 (2004), 139-151.