OBJECTIVE: When applied by well-trained personnel, skin prick test (SPT) for a variety of inhalant and/or food allergens is a safe procedure although it may rarely cause systemic reaction. In this article, our aim was to evaluate the reactions after SPTs for the past 6 years in Turkish children having various allergic symptoms brought to our clinic. METHODS: The results of the SPTs, performed between May 2013 and March 2019, of 12.529 patients whose ages vary from 2 months to 18 years have been retrospectively evaluated. RESULTS: The average age of the patients who were included in this study was 6.12±4.38 years and 46.4% of them were female. When the patients were categorized according to the diagnosis, it was observed that 4.858 of them with symptoms suggesting asthma; 2.720 of them having symptoms suggesting allergic rhinitis; 1.795 of them having rashes; 906 of them with atopic dermatitis; 352 of them having symptoms suggesting food allergy and the remaining 1.898 with symptoms suggesting various diagnoses. In this study, which reflects our 6-year experience from the results of 12.529 patients, post-SPT reactions have been observed in 9 out of 12.529 patients (0.07%). They were three females and six males. These reactions were observed in 3 eczemas, 2 urticaria, 2 allergic rhinitis, and 2 suggested diagnosis of asthma patients. Their mean age was 5.9±3.5 years. SPT reactions were mostly seen in our five patients having skin disorder (eczema and rashes). The most frequent symptom of vasovagal reaction was syncope, occuring between 1 and 20 min after SPT, in eight of nine patients. CONCLUSION: During our study, any systemic reaction or anaphylaxis to SPT was not observed. The non-systemic reaction (vasovagal reaction) rate was 7/10.000, similar to the literature