Objective: Although history and physical examination are the most reliable methods in the diagnosis of acute appendicitis, the difficulties experienced during physical examination in patients in the pediatric age group may require support with laboratory biomarkers. For this purpose, we combined the Alvarado score with ultrasonographic findings, some hematological parameters, C reactive protein / albumin ratio and platelet mass index to determine the effectiveness of its use individually or together in the diagnosis of acute appendicitis.Material and Methods: Patients who were operated with the diagnosis of acute appendicitis in our center between March 2019 and March 2020 were retrospectively analyzed. Demographic characteristics, biochemical parameters, radiological findings, Alvarado scoring were obtained from file records.Results: A total of 68 (M / F: 44/24) patients were included in the study. The average age of the patients was 11.04±3.71 years. There was a positive correlation between the Alvarado score and neutrophil / lymphocyte value, C reactive protein level, C reactive protein / albumin value, and appendix diameter and hematocrit level (ρ = 0.268, p <0.05). However, there was no relationship between the Alvarado score and mean platelet volume and platelet mass index (p> 0.05).Conclusion: The use of neutrophil / lymphocyte value, C reactive protein level, C reactive protein / albumin value, and the increase in hematocrit level together with the Alvarado score can be considered as a diagnostic marker in children with appendicitis when ultrasonography is not available and when the appendix cannot be visualized.