The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome

Harun SOYALIÇ, (Ahi Evran Üniversitesi Tıp Fakültesi, Kulak Burun Boğaz Anabilim Dalı, Kırşehir, Türkiye)
Handan İNÖNÜ KÖSEOĞLU, (Gaziosmanpaşa Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Anabilim Dalı, Tokat, Türkiye)
Duygu Zorlu KARAYİĞİT, (Ahi Evran Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Anabilim Dalı, Kırşehir, Türkiye)
Arzu ERTÜRK, (Ahi Evran Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Anabilim Dalı, Kırşehir, Türkiye)
Akın TEKCAN, (Amasya Üniversitesi Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Amasya, Türkiye)
Evrim ÜNSAL TUNA (Ankara Şehir Hastanesi, Kulak Burun Boğaz Kliniği, Ankara, Türkiye)
Türk Uyku Tıbbı Dergisi
4 0
Yıl: 2022 Cilt: 9 Sayı: 1 Sayfa Aralığı: 5 - 10 Metin Dili: İngilizce DOI: 10.4274/jtsm.galenos.2021.86580 İndeks Tarihi: 30-09-2022

The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome

Öz:
Objective: To investigate the association between obstructive sleep apnea syndrome (OSAS), glutathione peroxidase-1 (GPX1) Pro198Leu, and manganese superoxide dismutase (MnSOD) Ala16Val gene polymorphisms. Materials and Methods: The study included 81 patients with OSAS and 75 healthy controls from the Turkish population. Genotypes of the MnSOD rs4880 T/C (Ala16Val) and GPX1 rs1050450 T/C (Pro198Leu) variants were determined via single-nucleotide polymorphisms genotyping analysis, which is based on simple probe melting curve analysis. Results: The frequencies of the MnSOD rs4880 T/T, T/C, and C/C were 35.8%, 50.6%, and 13.5% in patients with OSAS and 34.6%, 49.3%, and 16% in the controls, respectively. No statistically significant difference was determined between patients and controls in terms of MnSOD rs4880 variant genotype and allele distribution (odds ratio: 1.07; 95% confidence interval: 0.68-1.69; p>0.05). The frequencies of the GPX1 rs1050450T/T, T/C, and C/C were 12.0%, 38.5%, and 49.4% in patients with OSAS and 13.1%, 42.1%, and 44.7% in the controls, respectively. No statistically significant difference was determined in the genotype and allele frequencies of the GPX1 rs1050450 variant between the patients and controls (p>0.05). Additionally, the haplotype was examined on the basis of combined genotypes for the two variants in patients with OSAS and controls, which revealed no statistically significant correlation. Conclusion: Our study indicates that two polymorphisms in these antioxidant enzymes were not associated with Turkish patients with OSAS. Further studies may reveal an association between these two polymorphisms with some clinical parameters in patients with OSAS.
Anahtar Kelime:

GPX1 Pro198Leu ve MnSOD Ala16Val Varyantları ile Obstrüktif Uyku Apnesi Sendromu Arasındaki İlişki

Öz:
Amaç: Bu çalışmanın amacı obstrüktif uyku apne sendromu (OUAS) ve glutatyon peroksidaz-1 (GPX1) Pro198Leu ve manganez süperoksit dismutaz (MnSOD) Ala16Val gen polimorfizmleri arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Çalışmaya OUAS’li 81 hasta ve 75 sağlıklı kontrol dahil edildi. MnSOD rs4880 T/C (Ala16Val) ve GPX1 rs1050450 T/C (Pro198Leu) varyantlarının genotipleri, SNP tipleme analizi ile belirlendi. Bulgular: MnSOD rs4880T/T, T/C, C/C frekansları hastalarda sırasıyla %35,8, %50,6 ve %13,5 ve kontrollerde %34,6, %49,3 ve %16 idi. Hastalar ve kontroller arasında MnSOD rs4880 varyant genotipi ve alel dağılımı açısından istatistiksel anlamlı fark saptanmadı (olasılık oranı: 1,07; %95 güven aralığı: 0,68-1,69; p>0,05). GPX1 rs1050450T/T, T/C, C/C frekansları hastalarda sırasıyla %12,0, %38,5 ve %49,4 ve kontrollerde %13,1, %42,1 ve %44,7 idi. Hastalar ve kontrol grubu arasında GPX1 rs1050450 varyantının genotip ve alel frekanslarında anlamlı bir fark gözlenmedi (p>0,05). Ayrıca OSAS hastalarında ve kontrol grubunda, iki varyant için kombine genotiplere dayanan haplotipi arasında ilişki saptanmadı. Sonuç: Çalışmamız, GPX1 Pro198Leu, MnSOD Ala16Val gen varyantlarının OUAS ile ilişkili olmadığını göstermektedir. İleri çalışmalar, bu iki polimorfizmin OUAS hastalarında bazı klinik parametrelerle ilişkili olduğunu ortaya çıkarabilir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA soyalıç h, Inonu Koseoglu H, Zorlu D, Ertürk A, TEKCAN A, tuna e (2022). The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome. , 5 - 10. 10.4274/jtsm.galenos.2021.86580
Chicago soyalıç harun,Inonu Koseoglu Handan,Zorlu Duygu,Ertürk Arzu,TEKCAN AKIN,tuna elvan evrim The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome. (2022): 5 - 10. 10.4274/jtsm.galenos.2021.86580
MLA soyalıç harun,Inonu Koseoglu Handan,Zorlu Duygu,Ertürk Arzu,TEKCAN AKIN,tuna elvan evrim The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome. , 2022, ss.5 - 10. 10.4274/jtsm.galenos.2021.86580
AMA soyalıç h,Inonu Koseoglu H,Zorlu D,Ertürk A,TEKCAN A,tuna e The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome. . 2022; 5 - 10. 10.4274/jtsm.galenos.2021.86580
Vancouver soyalıç h,Inonu Koseoglu H,Zorlu D,Ertürk A,TEKCAN A,tuna e The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome. . 2022; 5 - 10. 10.4274/jtsm.galenos.2021.86580
IEEE soyalıç h,Inonu Koseoglu H,Zorlu D,Ertürk A,TEKCAN A,tuna e "The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome." , ss.5 - 10, 2022. 10.4274/jtsm.galenos.2021.86580
ISNAD soyalıç, harun vd. "The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome". (2022), 5-10. https://doi.org/10.4274/jtsm.galenos.2021.86580
APA soyalıç h, Inonu Koseoglu H, Zorlu D, Ertürk A, TEKCAN A, tuna e (2022). The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome. Türk Uyku Tıbbı Dergisi, 9(1), 5 - 10. 10.4274/jtsm.galenos.2021.86580
Chicago soyalıç harun,Inonu Koseoglu Handan,Zorlu Duygu,Ertürk Arzu,TEKCAN AKIN,tuna elvan evrim The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome. Türk Uyku Tıbbı Dergisi 9, no.1 (2022): 5 - 10. 10.4274/jtsm.galenos.2021.86580
MLA soyalıç harun,Inonu Koseoglu Handan,Zorlu Duygu,Ertürk Arzu,TEKCAN AKIN,tuna elvan evrim The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome. Türk Uyku Tıbbı Dergisi, vol.9, no.1, 2022, ss.5 - 10. 10.4274/jtsm.galenos.2021.86580
AMA soyalıç h,Inonu Koseoglu H,Zorlu D,Ertürk A,TEKCAN A,tuna e The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome. Türk Uyku Tıbbı Dergisi. 2022; 9(1): 5 - 10. 10.4274/jtsm.galenos.2021.86580
Vancouver soyalıç h,Inonu Koseoglu H,Zorlu D,Ertürk A,TEKCAN A,tuna e The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome. Türk Uyku Tıbbı Dergisi. 2022; 9(1): 5 - 10. 10.4274/jtsm.galenos.2021.86580
IEEE soyalıç h,Inonu Koseoglu H,Zorlu D,Ertürk A,TEKCAN A,tuna e "The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome." Türk Uyku Tıbbı Dergisi, 9, ss.5 - 10, 2022. 10.4274/jtsm.galenos.2021.86580
ISNAD soyalıç, harun vd. "The Relationship Between GPX1 Pro198Leu Manganese Superoxide Dismutase Ala16Val Variants and Obstructive Sleep Apnea Syndrome". Türk Uyku Tıbbı Dergisi 9/1 (2022), 5-10. https://doi.org/10.4274/jtsm.galenos.2021.86580
Sayfa Oluşturulma Tarihi
24-04-2024 3:35

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