Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease
Yıl: 2021 Cilt: 12 Sayı: 1 Sayfa Aralığı: 29 - 32 Metin Dili: İngilizce DOI: 10.18663/tjcl.708810 İndeks Tarihi: 30-09-2022
Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease
Öz: Aim: Peripheral artery disease (PAD) is an atherosclerotic disease. It is seen in older ages. It causes cardiovascular morbidity and mortality. PAD may progress without any symptoms. Despite its high frequency, there is no laboratory parameter that directly indicates peripheral arterial disease in routine biochemical tests. The relationship between oxidative stress increase and PAD is known. In this study, it is aimed to show the possible usage of the activities of the antioxidant enzymes paraoxonase 1 and arylesterase as a new marker in the diagnosis of PAD. Material and Methods: A total of 70 individuals, including 35 in the control group and 35 peripheral artery patients, were included in this study. The collected blood serums were separated and stored at -80 °C. Paraoxonase 1 and arylesterase activities were measured using the spectrophotometric method in the serum which was dissolved at room temperature. The results were subjected to statistical analysis. P <0.05 was accepted as the level of significance. Results: In the peripheral arterial disease group, the paraoxonase 1 and arylesterase activities were found to be significantly lower than those in the control group (p <0.05). In peripheral arterial disease, paraoxonase 1 and arylesterase activities were shown to decrease. Conclusion: In peripheral arterial disease, paraoxonase 1 and arylesterase activities were found to decrease significantly. The results of similar studies related to atherosclerosis in the literature were in line with our findings. It would be beneficial to support the results of this study with new studies and evaluate paraoxonase 1 and arylesterase activities in routine biochemistry laboratories for the diagnosis and follow-up of peripheral arterial disease.
Anahtar Kelime: Periferik arter hastalığı tanısında yeni bir biyokimyasal gösterge olarak paraoksonaz 1 aktivitesi
Öz: Amaç: Periferik arter hastalığı (PAH) aterosklerotik bir hastalıktır. İleri yaşta görülür. Kardiyovasküler morbidite ve mortaliteye sebep olmaktadır. PAH, hiçbir belirti vermeden de seyredebilir. Sıklığı yüksek olmasına rağmen rutin biyokimyasal tetkiklerde direkt olarak periferik arter hastalığını gösteren bir laboratuvar parametresi bulunmamaktadır. Oksidatif stres artışı ile PAH arasındaki ilişki bilinmektedir. Bu çalışmada antioksidan enzimler olan paraoksonaz 1 ve arilesteraz aktivitelerinin PAH tanısında yeni bir marker olarak muhtemel kullanımının gösterilmesi amaçlanmıştır. Gereç ve Yöntemler: 35 kontrol grubu ve 35 Periferik arter hastası olmak üzere toplam 70 bireyin olurları alınarak çalışmaya dâhil edilmiştir. Toplanan kanlar serumları ayrılarak -80 Co’de saklanmıştır. Oda ısısında çözünen serumlarda ticari kit kullanılarak, spektrofotometrik yöntem ile paraoksonaz 1 ve arilesteraz aktiviteleri ölçülmüştür. Sonuçlar istatistiksel analize tabi tutulmuştur. Anlamlılık düzeyi olarak p<0,05 kabul edilmiştir. Bulgular: Periferik arter hastalığı grubunda, paraoksonaz 1 ve arilesteraz aktiviteleri, kontrol grubuna göre istatistiksel olarak anlamlı düzeyde düşük bulunmuştur (p<0,05). Periferik arter hastalığında paraoksonaz 1 ve arilesteraz aktivitelerinin azaldığı görülmüştür. Sonuç: Periferik arter hastalığında paraoksonaz 1 ve arilesteraz aktivitelerinin istatistiksel olarak anlamlı düzeyde azaldığı görülmüştür. Literatürde ateroskleroz ile ilgili benzer çalışmaların sonuçları bulgularımız ile uyumludur. Yeni çalışmalarla desteklenmesi faydalı olmakla birlikte paraoksonaz 1 ve arilesteraz aktivitelerinin rutin biyokimya laboratuvarlarında bakılmasının periferik arter hastalığı tanısında ve takibinde değeri olabilecektir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | SAVAS H, ETLİ M (2021). Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease. , 29 - 32. 10.18663/tjcl.708810 |
| Chicago | SAVAS Hasan Basri,ETLİ MUSTAFA Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease. (2021): 29 - 32. 10.18663/tjcl.708810 |
| MLA | SAVAS Hasan Basri,ETLİ MUSTAFA Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease. , 2021, ss.29 - 32. 10.18663/tjcl.708810 |
| AMA | SAVAS H,ETLİ M Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease. . 2021; 29 - 32. 10.18663/tjcl.708810 |
| Vancouver | SAVAS H,ETLİ M Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease. . 2021; 29 - 32. 10.18663/tjcl.708810 |
| IEEE | SAVAS H,ETLİ M "Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease." , ss.29 - 32, 2021. 10.18663/tjcl.708810 |
| ISNAD | SAVAS, Hasan Basri - ETLİ, MUSTAFA. "Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease". (2021), 29-32. https://doi.org/10.18663/tjcl.708810 |
| APA | SAVAS H, ETLİ M (2021). Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease. Turkish Journal of Clinics and Laboratory, 12(1), 29 - 32. 10.18663/tjcl.708810 |
| Chicago | SAVAS Hasan Basri,ETLİ MUSTAFA Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease. Turkish Journal of Clinics and Laboratory 12, no.1 (2021): 29 - 32. 10.18663/tjcl.708810 |
| MLA | SAVAS Hasan Basri,ETLİ MUSTAFA Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease. Turkish Journal of Clinics and Laboratory, vol.12, no.1, 2021, ss.29 - 32. 10.18663/tjcl.708810 |
| AMA | SAVAS H,ETLİ M Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease. Turkish Journal of Clinics and Laboratory. 2021; 12(1): 29 - 32. 10.18663/tjcl.708810 |
| Vancouver | SAVAS H,ETLİ M Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease. Turkish Journal of Clinics and Laboratory. 2021; 12(1): 29 - 32. 10.18663/tjcl.708810 |
| IEEE | SAVAS H,ETLİ M "Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease." Turkish Journal of Clinics and Laboratory, 12, ss.29 - 32, 2021. 10.18663/tjcl.708810 |
| ISNAD | SAVAS, Hasan Basri - ETLİ, MUSTAFA. "Paraoxonase 1 activity as a new biochemical marker in the diagnosis of peripheral arterial disease". Turkish Journal of Clinics and Laboratory 12/1 (2021), 29-32. https://doi.org/10.18663/tjcl.708810 |
