Aim: Due to the COVID-19 pandemic, an increase in awareness is observed in the use of hand hygiene, alcohol-based disinfectant use, gloves, masks, and other barrier measures in healthcare personnel. Our study aims to compare whether there is a difference in the rates of infections in patients who need intensive care follow-up in the non-COVID-19 patient group in the first 6 months of 2019 and 2020. Material and Methods: All patients admitted to the secondary level Pulmonary Intensive Care Unit (PICU) for 6 months between 01/01/2019-30/06/2019 (control group) and 6 months between 01/01/2020-30/06/2020 (case group) were included in the study. There were no exclusion criteria in our study. Patients who were found to be positive for COVID-19 PCR test or whose COVID-19 PCR test was negative, but was thought to have COVID-19 disease with clinical and radiological suspicion, and/or for whom specific treatment was initiated/continued, were not included in our study because they were not taken to our intensive care unit during this period. Results: The control group (n=327) and case group (n=260) of the study were similar in terms of demographic findings and general characteristics. Among the groups, there was no statistically significant relationship between the groups in terms of age, gender, where the patient was transferred to the ICU, where the patient was discharged, intubation history in the tertiary intensive care unit before PICU, presence of LTOT, and/or NIV devices at home, device types reported to the home at discharge and mortality status at post-discharge follow-up, the need for NIV in the hospital and the number of NIV days, the number of days of hospitalization in the tertiary ICU and the number of days of NIV application. There was no statistically significant difference between the control group and the case group in terms of the growth status of all cultures taken from the patients and the microorganisms grown in the cultures (p=0.775 and p=0.137, respectively). Conclusion: In our study, although there was an increase in the awareness of healthcare personnel working in the PICU about hand hygiene and barrier measures, there was no difference between periods in high-risk resistant bacterial growths and there was no difference between periods in diagnosed infections, which shows that infection control measures were internalized and applied.