The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits

Etyemez, Muhammed; GÜLAY, MEHMET SÜKRÜ

doi:10.24880/maeuvfd.1138340

The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits

Muhammed ETYEMEZ, (Hatay Mustafa Kemal Üniversitesi, Veteriner Fakültesi, Fizyoloji Anabilim Dalı, Hatay, Türkiye)

Mehmet Şükrü GÜLAY (Burdur Mehmet Akif Ersoy Üniversitesi, Veteriner Fakültesi, Fizyoloji Anabilim Dalı, Burdur, Türkiye)

Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi

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Yıl: 2022 Cilt: 7 Sayı: 3 Sayfa Aralığı: 207 - 217 Metin Dili: İngilizce DOI: 10.24880/maeuvfd.1138340 İndeks Tarihi: 09-01-2023

The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits

Öz:

Bisphenol AF (BPAF) is used as an analog of the endocrine disruptor Bisphenol A (BPA), whereas safranal is a powerful antioxidant obtained from the saffron plant. In the current study, the possible effects of BPAF and Safranal on some spermatological parameters, reproductive hormones, oxidant/antioxidant enzymes, and histopathological parameters were investigated. A total of 24 male New Zealand rabbits were divided into 4 groups (n= 6 for each group). The groups and the treatments they received by oral gavage for 9 weeks are as follows: The control group received by oral gavage 1 ml/day of corn oil, the BPAF group received by oral gavage 20 mg/kg/day of bisphenol AF, the Safranal group received by oral gavage 100 mg/kg/day safranal, and the treatment group received by oral gavage 20 mg/kg/day bisphenol AF and 100 mg/kg/day safranal. Although the spermatological parameters (sperm concentration, ejaculate volume, progressive motility, ejaculate weight, seminal plasma total protein, and pH) prior to the experiment revealed no differences among the groups, BPAF treatment reduced sperm quantity and motility at the end of the study. BPAF treatments also had a negative impact on testicular MDA and GSH levels. It also caused seminiferous tubule degeneration in testicular tissue. On the other hand, the administration of safranal with BPAF decreased estrogen levels while increasing sperm concentration and motility to control group levels. Thus, the results suggested that safranal could have a beneficial effect in reducing BPAF-induced tissue damage. In conclusion, BPAF may have potentially harmful to the male reproductive system and safranal may exhibit a protective effect against BPAF exposure.

Anahtar Kelime: Bisphenol AF male rabbit reproduction safranal

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Etyemez M, GÜLAY M (2022). The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits. , 207 - 217. 10.24880/maeuvfd.1138340
Chicago	Etyemez Muhammed,GÜLAY MEHMET SÜKRÜ The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits. (2022): 207 - 217. 10.24880/maeuvfd.1138340
MLA	Etyemez Muhammed,GÜLAY MEHMET SÜKRÜ The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits. , 2022, ss.207 - 217. 10.24880/maeuvfd.1138340
AMA	Etyemez M,GÜLAY M The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits. . 2022; 207 - 217. 10.24880/maeuvfd.1138340
Vancouver	Etyemez M,GÜLAY M The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits. . 2022; 207 - 217. 10.24880/maeuvfd.1138340
IEEE	Etyemez M,GÜLAY M "The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits." , ss.207 - 217, 2022. 10.24880/maeuvfd.1138340
ISNAD	Etyemez, Muhammed - GÜLAY, MEHMET SÜKRÜ. "The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits". (2022), 207-217. https://doi.org/10.24880/maeuvfd.1138340

APA	Etyemez M, GÜLAY M (2022). The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits. Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi, 7(3), 207 - 217. 10.24880/maeuvfd.1138340
Chicago	Etyemez Muhammed,GÜLAY MEHMET SÜKRÜ The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits. Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi 7, no.3 (2022): 207 - 217. 10.24880/maeuvfd.1138340
MLA	Etyemez Muhammed,GÜLAY MEHMET SÜKRÜ The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits. Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi, vol.7, no.3, 2022, ss.207 - 217. 10.24880/maeuvfd.1138340
AMA	Etyemez M,GÜLAY M The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits. Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi. 2022; 7(3): 207 - 217. 10.24880/maeuvfd.1138340
Vancouver	Etyemez M,GÜLAY M The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits. Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi. 2022; 7(3): 207 - 217. 10.24880/maeuvfd.1138340
IEEE	Etyemez M,GÜLAY M "The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits." Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi, 7, ss.207 - 217, 2022. 10.24880/maeuvfd.1138340
ISNAD	Etyemez, Muhammed - GÜLAY, MEHMET SÜKRÜ. "The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits". Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi 7/3 (2022), 207-217. https://doi.org/10.24880/maeuvfd.1138340