Parao[onase 1 Activities in First Trimester Miscarriages

SAVAS, Hasan Basri; Erdem, Dilek

doi:10.38136/jgon.783946

Parao[onase 1 Activities in First Trimester Miscarriages

Hasan Basri SAVAŞ, (Alanya Alaaddin Keykubat Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Antalya, Türkiye)

Dilek ERDEM (Alanya Alaaddin Keykubat Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Antalya, Türkiye)

Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi

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Yıl: 2021 Cilt: 18 Sayı: 2 Sayfa Aralığı: 770 - 775 Metin Dili: İngilizce DOI: 10.38136/jgon.783946 İndeks Tarihi: 25-01-2023

Parao[onase 1 Activities in First Trimester Miscarriages

Öz:

Aim: Miscarriages are becoming increasingly important problem nowadays. First trimester pregnancy loss frequency in women of reproductive age is increasing. In this study, it is aimed to show the possible relationship between first trimester pregnancy losses and PON1 and ARY activities. Material and Method: 25 pregnant healthy women (Group 1) and 25 women with first trimester miscarriage (Group 2) in 6-14 gestational weeks were included in this study. Paraoxonase 1 and arylesterase activities of the sera samples were investigated using fully automated colorimetric methods. ANOVA test was used to compare the groups. Results: PON1 and ARY activities are statistically significantly lower in pregnant women with first trimester miscarriage compared to healthy pregnant women in first trimester analyzed by Anova test (p<0.05). Conclusion: The results of this study showed that paraoxonase 1 and arylesterase antioxidant enzyme activities can be evaluated as significant predictive clinical laboratory parameters in first trimester pregnancy losses. If this study is confirmed with larger patient groups, our research results will gain more value.

Anahtar Kelime: Pregnants first trimester miscarriage paraoxonase 1 arylesterase

Birinci Trimester Düşüklerinde Paraoksonaz 1 Aktiviteleri

Öz:

Amaç: Düşükler günümüzde giderek daha önemli bir sorun haline gelmektedir. Üreme çağındaki kadınlarda ilk trimester gebelik kaybının sıklığı artmaktadır. Bu çalışmada, ilk trimester gebelik kayıpları ile PON1 ve ARY düzeyleri arasındaki olası ilişkinin gösterilmesi amaçlanmıştır. Gereçler ve Yöntem: 6-14 gebelik haftasında 25 gebe sağlıklı kadın (Grup 1) ve ilk trimester düşüklü (Grup 2) 25 kadın çalışmaya dahil edildi. Serum örneklerinde paraoksonaz 1 ve arilesteraz aktiviteleri, tam otomatik kolorimetrik yöntemler kullanılarak araştırıldı. Grupları karşılaştırmak için ANOVA testi kullanıldı. Bulgular: PON1 ve ARY aktiviteleri, ilk trimesterde düşük yapan gebelerde Anova testi ile analiz edilen ilk trimesterdeki sağlıklı gebe kadınlara göre istatistiksel olarak anlamlı derecede düşüktür (p <0,05). Sonuç: Bu çalışmanın sonuçları, ilk trimester gebelik kayıplarında paraoksonaz 1 ve arilesteraz antioksidan enzim aktivitelerinin anlamlı prediktif klinik laboratuvar parametreleri olarak değerlendirilebildiğini göstermiştir. Bu çalışma daha büyük hasta gruplarıyla doğrulanırsa, araştırma sonuçlarımız değer kazanacaktır.

Anahtar Kelime: Gebeler birinci trimester düşük paraoksonaz 1 arilesteraz

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	SAVAS H, Erdem D (2021). Parao[onase 1 Activities in First Trimester Miscarriages. , 770 - 775. 10.38136/jgon.783946
Chicago	SAVAS Hasan Basri,Erdem Dilek Parao[onase 1 Activities in First Trimester Miscarriages. (2021): 770 - 775. 10.38136/jgon.783946
MLA	SAVAS Hasan Basri,Erdem Dilek Parao[onase 1 Activities in First Trimester Miscarriages. , 2021, ss.770 - 775. 10.38136/jgon.783946
AMA	SAVAS H,Erdem D Parao[onase 1 Activities in First Trimester Miscarriages. . 2021; 770 - 775. 10.38136/jgon.783946
Vancouver	SAVAS H,Erdem D Parao[onase 1 Activities in First Trimester Miscarriages. . 2021; 770 - 775. 10.38136/jgon.783946
IEEE	SAVAS H,Erdem D "Parao[onase 1 Activities in First Trimester Miscarriages." , ss.770 - 775, 2021. 10.38136/jgon.783946
ISNAD	SAVAS, Hasan Basri - Erdem, Dilek. "Parao[onase 1 Activities in First Trimester Miscarriages". (2021), 770-775. https://doi.org/10.38136/jgon.783946

APA	SAVAS H, Erdem D (2021). Parao[onase 1 Activities in First Trimester Miscarriages. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, 18(2), 770 - 775. 10.38136/jgon.783946
Chicago	SAVAS Hasan Basri,Erdem Dilek Parao[onase 1 Activities in First Trimester Miscarriages. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 18, no.2 (2021): 770 - 775. 10.38136/jgon.783946
MLA	SAVAS Hasan Basri,Erdem Dilek Parao[onase 1 Activities in First Trimester Miscarriages. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, vol.18, no.2, 2021, ss.770 - 775. 10.38136/jgon.783946
AMA	SAVAS H,Erdem D Parao[onase 1 Activities in First Trimester Miscarriages. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2021; 18(2): 770 - 775. 10.38136/jgon.783946
Vancouver	SAVAS H,Erdem D Parao[onase 1 Activities in First Trimester Miscarriages. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2021; 18(2): 770 - 775. 10.38136/jgon.783946
IEEE	SAVAS H,Erdem D "Parao[onase 1 Activities in First Trimester Miscarriages." Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, 18, ss.770 - 775, 2021. 10.38136/jgon.783946
ISNAD	SAVAS, Hasan Basri - Erdem, Dilek. "Parao[onase 1 Activities in First Trimester Miscarriages". Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 18/2 (2021), 770-775. https://doi.org/10.38136/jgon.783946