COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR  BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL  SEPTUM DEVIATED PATIENTS

ilanbey, Bilal; CELİK, MUSTAFA; ALPASLAN, Muhammed; soyalıç, harun; dadalı, yeliz; ünsal, evrim

COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS

Harun SOYALIÇ, (Ahi Evran Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz, Kırşehir, Türkiye)

Yeliz DADALI, (Ahi Evran Üniversitesi, Tıp Fakültesi, Radyoloji, Kırşehir, Türkiye)

Bilal ILANBEY, (Ahi Evran Üniversitesi, Tıp Fakültesi, Biyokimya, Kırşehir, Türkiye)

Mustafa ÇELİK, (Ahi Evran Üniversitesi, Tıp Fakültesi, Kardiyoloji, Kırşehir, Türkiye)

Muhammed ALPASLAN, (Ahi Evran Üniversitesi, Tıp Fakültesi, Radyoloji, Kırşehir, Türkiye)

evrim ünsal (Sağlık Bilimleri Üniversitesi, Bilkent Şehir Hastanesi, Kulak Burun Boğaz, Ankara, Türkiye)

KBB-Forum

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Yıl: 2023 Cilt: 22 Sayı: 1 Sayfa Aralığı: 100 - 113 Metin Dili: İngilizce İndeks Tarihi: 23-05-2023

COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS

Öz:

Objective: In our study, we aimed to analyse the carotid intima-media thickness (CIMT), systemic cardiac failure parameters, and serum copeptin concentrations in patients with severe nasal septum deviation (NSD) causing severe nasal obstruction and evaluating the diagnostic value of these parameters for the early onset of cardiovascular diseases in these patients. Methods: The sample involved 57 patients with severe NSD and 50 individuals in the control group. The diagnosis of severe NSD was made following nasal endoscopic examination. CIMT and cardiac failure parameters were evaluated with carotid ultrasonography and echocardiography. Copeptin levels in the sera of the patients were examined with the enzyme-linked immunosorbent assay method (ELISA). Results: Right and left CIMT values, serum copeptin measurements, and log (serum copeptin level) values were significantly higher in the patient group in comparison to the control group (p<0.001 for all). In the results of the univariate analysis, the log serum copeptin and right and left carotid intima thickness variables were significantly associated with severe NSD (p<0.001). The multivariate analysis results demonstrated a significant relationship of only log serum copeptin with NSD (p=0.015). The ROC (receiver operating characteristic) curve examinations of the log serum copeptin values of the patients with severe NSD revealed an AUC (area under the curve) value of 0.72. The specificity of this measure was 86%, and its sensitivity was 50.9%. Conclusion: When used together, serum copeptin values and CIMT measurements can serve as biomarkers for the early monitoring of cardiovascular diseases in patients with severe NSD causing complete nasal congestion.

Anahtar Kelime:

İLERİ DERECEDE NAZAL SEPTUM DEVİASYONU OLAN HASTALARDA ERKEN KARDİYOVASKÜLER HASTALIĞIN BELİRTEÇLERİ: COPEPTİN VE KAROTİD İNTİMA-MEDİA KALINLIĞI

Öz:

Amaç: Çalışmamızda ileri derecede burun tıkanıklığı yaşayan ciddi nazal septum deviasyonlu (NSD) hastalarda karotis intima- media kalınlığı (KİMK), sistemik kalp yetmezliği parametreleri ve serum kopeptin konsantrasyonlarını belirleyerek bu bulguların ciddi NSD’li hastalardaki erken kardiyovasküler hastalık için tanısal değerini araştırdık. Materyal ve Metod: Ciddi NSD'li 57 hasta ve 50 sağlıklı birey çalışmaya dahil edildi. Ciddi NSD tanısı nazal endoskopik incelemenin ardından konuldu. KİMK ve kalp yetmezliği parametreleri karotis ultrasonografisi ve ekokardiyografi ile değerlendirildi. Hastaların serumlarındaki kopeptin düzeyleri ELISA (enzyme-linked immunosorbent assay) yöntemi ile incelendi. Bulgular: Hasta grubunda sağ ve sol KİMK değerleri, serum kopeptin ölçümleri ve log (serum kopeptin düzeyi) değerleri kontrol grubuna göre anlamlı olarak yüksekti (tümü için p<0.001). Univaryant analiz sonuçlarında log serum kopeptin ve sağ ve sol karotid intima kalınlık değişkenleri şiddetli NSD ile anlamlı derecede ilişkiliydi (p<0.001). Multivaryant analiz sonuçlarında, yalnızca log serum kopeptin ile NSD arasında anlamlı bir ilişki olduğu gözlendi. (p=0.015). Ciddi NSD'si olan hastaların log serum kopeptin değerlerinin ROC eğrisi incelemelerinde AUC değeri 0,72 olarak bulundu. Bu ölçümün özgüllüğü %86, duyarlılığı %50,9 idi. Sonuç: Serum kopeptin değerleri ve KİMK ölçümleri birlikte kullanıldığında, neredeyse tama yakın burun tıkanıklığı olan ciddi NSD'li hastalardaki kardiyovasküler hastalıkların erken tanısı için biyobelirteç olarak kullanılabilirler.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Diğer Erişim Türü: Erişime Açık

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APA	soyalıç h, dadalı y, ilanbey B, CELİK M, ALPASLAN M, ünsal e (2023). COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS. , 100 - 113.
Chicago	soyalıç harun,dadalı yeliz,ilanbey Bilal,CELİK MUSTAFA,ALPASLAN Muhammed,ünsal evrim COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS. (2023): 100 - 113.
MLA	soyalıç harun,dadalı yeliz,ilanbey Bilal,CELİK MUSTAFA,ALPASLAN Muhammed,ünsal evrim COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS. , 2023, ss.100 - 113.
AMA	soyalıç h,dadalı y,ilanbey B,CELİK M,ALPASLAN M,ünsal e COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS. . 2023; 100 - 113.
Vancouver	soyalıç h,dadalı y,ilanbey B,CELİK M,ALPASLAN M,ünsal e COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS. . 2023; 100 - 113.
IEEE	soyalıç h,dadalı y,ilanbey B,CELİK M,ALPASLAN M,ünsal e "COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS." , ss.100 - 113, 2023.
ISNAD	soyalıç, harun vd. "COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS". (2023), 100-113.

APA	soyalıç h, dadalı y, ilanbey B, CELİK M, ALPASLAN M, ünsal e (2023). COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS. KBB-Forum, 22(1), 100 - 113.
Chicago	soyalıç harun,dadalı yeliz,ilanbey Bilal,CELİK MUSTAFA,ALPASLAN Muhammed,ünsal evrim COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS. KBB-Forum 22, no.1 (2023): 100 - 113.
MLA	soyalıç harun,dadalı yeliz,ilanbey Bilal,CELİK MUSTAFA,ALPASLAN Muhammed,ünsal evrim COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS. KBB-Forum, vol.22, no.1, 2023, ss.100 - 113.
AMA	soyalıç h,dadalı y,ilanbey B,CELİK M,ALPASLAN M,ünsal e COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS. KBB-Forum. 2023; 22(1): 100 - 113.
Vancouver	soyalıç h,dadalı y,ilanbey B,CELİK M,ALPASLAN M,ünsal e COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS. KBB-Forum. 2023; 22(1): 100 - 113.
IEEE	soyalıç h,dadalı y,ilanbey B,CELİK M,ALPASLAN M,ünsal e "COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS." KBB-Forum, 22, ss.100 - 113, 2023.
ISNAD	soyalıç, harun vd. "COPEPTIN AND CAROTID INTIMA-MEDIA THICKNESS AS PREDICTOR BIOMARKERS OF EARLY CARDIOVASCULAR DISEASE IN SEVERE NASAL SEPTUM DEVIATED PATIENTS". KBB-Forum 22/1 (2023), 100-113.