Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat

Kara, Ozlem; Kilitci, Asuman

Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat

Ozlem Kara, (Kırşehir Ahi Evran Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Kırşehir, TÜRKİYE)

Asuman KİLİTCİ (Düzce Üniversitesi, Tıp Fakültesi, Anabilim Dalı Patoloji, Düzce, TÜRKİYE)

Ege Klinikleri Tıp Dergisi

17 3

Yıl: 2023 Cilt: 61 Sayı: 1 Sayfa Aralığı: 64 - 68 Metin Dili: İngilizce İndeks Tarihi: 07-06-2023

Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat

Öz:

Aim: We aimed to evaluate the effect of astaxanthin on amiodarone induced kidney tissue damage. Methods: 3 groups were formed using 30 Wistar albino rats. In group 1 (control group) (n=10), neither any drugs were given nor anything was performed. In group 2 (amiodarone group) (n=10), 100 mg/kg amiodarone was given for 7 days. In group 3 (amiodarone+astaxanthin group) (n=10), 100 mg/kg amiodarone and 25 mg/kg astaxanthin were given for 7 days. Right kidneys were surgically extirpated in all groups. Blood malondialdehyde (MDA) levels and activities of catalase (CAT) and superoxide dismutase (SOD) were measured. Also, toxicity markers such as vascular congestion, hemorrhage, tubule degeneration and glomerular damage were assessed by examining the slides prepared from kidney tissue with microscopy. Results: The MDA levels were significantly higher and the activities of SOD, and CAT were lower in group 2 than group 3 (p<0.05). Tissue damage was significantly higher in group 2 than group 3 (p<0.05). Conclusion: According to our short term findings, astaxanthin reversed the toxicity of amiodarone on kidney tissue.

Anahtar Kelime:

Amiodaron’un Neden Olduğu Sıçan Doku Toksisitesinde Astaksantin’in Antioksidan Etkinliği

Öz:

Amaç: Astaksantin'in amiodaronun neden olduğu böbrek dokusu hasarı üzerindeki etkisini değerlendirmeyi amaçladık. Yöntemler: 30 adet Wistar albino rat kullanılarak 3 grup oluşturuldu. Grup 1'de (kontrol grubu) (n=10) herhangi bir ilaç verilmedi ve herhangi bir işlem yapılmadı. Grup 2'ye (amiodaron grubu) (n=10) 100 mg/kg amiodaron 7 gün verildi. Grup 3'e (amiodaron+astaksantin grubu) (n=10) 100 mg/kg amiodaron ve 25 mg/kg astaksantin 7 gün verildi. Tüm gruplarda sağ böbrekler cerrahi olarak çıkarıldı. Kan malondialdehit (MDA) seviyeleri ve katalaz (CAT) ve süperoksit dismutaz (SOD) aktiviteleri ölçüldü. Ayrıca böbrek dokusundan hazırlanan lamlar mikroskopi ile incelenerek damar tıkanıklığı, kanama, tübül dejenerasyonu ve glomerüler hasar gibi toksisite belirteçleri değerlendirildi. Bulgular: Grup 2'de MDA düzeyleri grup 3'e göre anlamlı olarak daha yüksek, SOD ve CAT aktiviteleri daha düşüktü (p<0.05). Doku hasarı grup 2'de grup 3'e göre anlamlı olarak yüksekti (p<0,05). Sonuç: Kısa vadeli bulgularımıza göre astaksantin, amiodaronun böbrek dokusu üzerindeki toksisitesini tersine çevirmiştir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Kara O, Kilitci A (2023). Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat. , 64 - 68.
Chicago	Kara Ozlem,Kilitci Asuman Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat. (2023): 64 - 68.
MLA	Kara Ozlem,Kilitci Asuman Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat. , 2023, ss.64 - 68.
AMA	Kara O,Kilitci A Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat. . 2023; 64 - 68.
Vancouver	Kara O,Kilitci A Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat. . 2023; 64 - 68.
IEEE	Kara O,Kilitci A "Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat." , ss.64 - 68, 2023.
ISNAD	Kara, Ozlem - Kilitci, Asuman. "Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat". (2023), 64-68.

APA	Kara O, Kilitci A (2023). Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat. Ege Klinikleri Tıp Dergisi, 61(1), 64 - 68.
Chicago	Kara Ozlem,Kilitci Asuman Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat. Ege Klinikleri Tıp Dergisi 61, no.1 (2023): 64 - 68.
MLA	Kara Ozlem,Kilitci Asuman Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat. Ege Klinikleri Tıp Dergisi, vol.61, no.1, 2023, ss.64 - 68.
AMA	Kara O,Kilitci A Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat. Ege Klinikleri Tıp Dergisi. 2023; 61(1): 64 - 68.
Vancouver	Kara O,Kilitci A Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat. Ege Klinikleri Tıp Dergisi. 2023; 61(1): 64 - 68.
IEEE	Kara O,Kilitci A "Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat." Ege Klinikleri Tıp Dergisi, 61, ss.64 - 68, 2023.
ISNAD	Kara, Ozlem - Kilitci, Asuman. "Antioxidant Efficacy Of Astaxanthin On Amiodarone Induced Toxicity in Rat". Ege Klinikleri Tıp Dergisi 61/1 (2023), 64-68.