Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations

ALTINÖZ, Eda; çavuş, Muhammet Serdar; Altuner, Ergin Murat; ZURNACI, Merve; ŞENTURAN, Merve; ŞENER, İZZET; SAHIN, CIGDEM; Şener, Nesrin; gür, mahmut

doi:10.17350/HJSE19030000297

Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations

MAHMUT GÜR, (Kastamonu Üniversitesi, Orman Endüstri Mühendisliği Bölümü, Kastamonu, Türkiye)

Merve ZURNACI, (Kastamonu Üniversitesi, Merkez Araştırma Laboratuvarı, Kastamonu, Türkiye)

Eda ALTINÖZ, (Kastamonu Üniversitesi, Fen Bilimleri Enstitüsü, Kastamonu, Türkiye)

Nesrin ŞENER, (Kastamonu Üniversitesi, Kimya Bölümü, Kastamonu, Türkiye)

CIGDEM SAHIN, (İstanbul Medeniyet Üniversitesi, Mühendislik Temel Bilimleri Bölümü, İstanbul, Türkiye)

Merve ŞENTURAN, (Kastamonu Üniversitesi, Fen Bilimleri Enstitüsü, Kastamonu, Türkiye)

İzzet ŞENER, (Kastamonu Üniversitesi, Kimya Bölümü, Kastamonu, Türkiye)

Muhammet ÇAVUŞ, (Kastamonu Üniversitesi, Kimya Bölümü, Kastamonu, Türkiye)

Ergin Murat ALTUNER (Kastamonu Üniversitesi, Fen Bilimleri Enstitüsü, Kastamonu, Türkiye)

Hittite Journal of Science and Engineering

6 2

Yıl: 2023 Cilt: 10 Sayı: 2 Sayfa Aralığı: 99 - 116 Metin Dili: İngilizce DOI: 10.17350/HJSE19030000297 İndeks Tarihi: 31-07-2023

Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations

Öz:

In this study, 1,3,4-thiadiazole derivatives were obtained from the reaction of benzophenone-4,4'-dicarboxylic acid and N-substitute-thiosemicarbazide compounds with each other. After the synthesis of the final products, some biological properties of these compounds such as antibiofilm, antimicrobial and efflux pump inhibiting efficiencies were evaluated. According to the MBC/MFC test, all the activities were found to be bacteriostatic, also, especially the biofilm inhibition activity of C1 against K. pneumoniae is noteworthy. In addition, C4 was observed to exhibit efflux pump inhibition activity in E. coli, whereas C2 and C3 in K. pneumoniae. The absorption and emission values of the molecules were obtained and electrochemical studies were performed. In addition; absorption, metabolism, distribution, excretion and toxicity (ADMET) scores were predicted using the pharmacokinetic properties of all 1,3,4-thiadiazole compounds. Finally, the electrochemical stabilities of the synthesized molecules have been analyzed by using cyclic voltammetry in 0.1 M TBAPF6 in DMSO as a supporting electrolyte.

Anahtar Kelime: Efflux pump inhibition antibiofilm antibacterial ADMET QSAR

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	gür m, ZURNACI M, ALTINÖZ E, Şener N, SAHIN C, ŞENTURAN M, ŞENER İ, çavuş M, Altuner E (2023). Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations. , 99 - 116. 10.17350/HJSE19030000297
Chicago	gür mahmut,ZURNACI Merve,ALTINÖZ Eda,Şener Nesrin,SAHIN CIGDEM,ŞENTURAN Merve,ŞENER İZZET,çavuş Muhammet Serdar,Altuner Ergin Murat Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations. (2023): 99 - 116. 10.17350/HJSE19030000297
MLA	gür mahmut,ZURNACI Merve,ALTINÖZ Eda,Şener Nesrin,SAHIN CIGDEM,ŞENTURAN Merve,ŞENER İZZET,çavuş Muhammet Serdar,Altuner Ergin Murat Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations. , 2023, ss.99 - 116. 10.17350/HJSE19030000297
AMA	gür m,ZURNACI M,ALTINÖZ E,Şener N,SAHIN C,ŞENTURAN M,ŞENER İ,çavuş M,Altuner E Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations. . 2023; 99 - 116. 10.17350/HJSE19030000297
Vancouver	gür m,ZURNACI M,ALTINÖZ E,Şener N,SAHIN C,ŞENTURAN M,ŞENER İ,çavuş M,Altuner E Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations. . 2023; 99 - 116. 10.17350/HJSE19030000297
IEEE	gür m,ZURNACI M,ALTINÖZ E,Şener N,SAHIN C,ŞENTURAN M,ŞENER İ,çavuş M,Altuner E "Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations." , ss.99 - 116, 2023. 10.17350/HJSE19030000297
ISNAD	gür, mahmut vd. "Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations". (2023), 99-116. https://doi.org/10.17350/HJSE19030000297

APA	gür m, ZURNACI M, ALTINÖZ E, Şener N, SAHIN C, ŞENTURAN M, ŞENER İ, çavuş M, Altuner E (2023). Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations. Hittite Journal of Science and Engineering, 10(2), 99 - 116. 10.17350/HJSE19030000297
Chicago	gür mahmut,ZURNACI Merve,ALTINÖZ Eda,Şener Nesrin,SAHIN CIGDEM,ŞENTURAN Merve,ŞENER İZZET,çavuş Muhammet Serdar,Altuner Ergin Murat Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations. Hittite Journal of Science and Engineering 10, no.2 (2023): 99 - 116. 10.17350/HJSE19030000297
MLA	gür mahmut,ZURNACI Merve,ALTINÖZ Eda,Şener Nesrin,SAHIN CIGDEM,ŞENTURAN Merve,ŞENER İZZET,çavuş Muhammet Serdar,Altuner Ergin Murat Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations. Hittite Journal of Science and Engineering, vol.10, no.2, 2023, ss.99 - 116. 10.17350/HJSE19030000297
AMA	gür m,ZURNACI M,ALTINÖZ E,Şener N,SAHIN C,ŞENTURAN M,ŞENER İ,çavuş M,Altuner E Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations. Hittite Journal of Science and Engineering. 2023; 10(2): 99 - 116. 10.17350/HJSE19030000297
Vancouver	gür m,ZURNACI M,ALTINÖZ E,Şener N,SAHIN C,ŞENTURAN M,ŞENER İ,çavuş M,Altuner E Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations. Hittite Journal of Science and Engineering. 2023; 10(2): 99 - 116. 10.17350/HJSE19030000297
IEEE	gür m,ZURNACI M,ALTINÖZ E,Şener N,SAHIN C,ŞENTURAN M,ŞENER İ,çavuş M,Altuner E "Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations." Hittite Journal of Science and Engineering, 10, ss.99 - 116, 2023. 10.17350/HJSE19030000297
ISNAD	gür, mahmut vd. "Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations". Hittite Journal of Science and Engineering 10/2 (2023), 99-116. https://doi.org/10.17350/HJSE19030000297