Objective: Whether drains should be routinely used after laparoscopic cholecystectomy is still debated. We aimed to retrospectivelyevaluate the benefits of drain use after laparoscopic cholecystectomyfor non-acute and non-inflamed gallbladders.Materials and Methods: Two hundred and fifty patients (mean age, 47±13.8 years; 200 females and 50 males) who underwent laparoscopic cholecystectomy for cholestasis were included in the study. The medical files of the patients were examined retrospectively to obtain data on patient demographics, cholecystitis attacks, com- plications during the operation, whether a drain was placed in the biliary tract during the operation, etc. The volume of the fluid collection detected in the subhepatic area by ultrasonography on the first postoperative day was recorded. Results: Drains were placed in 51 patients (20.4%). The mean duration of drain placement was 3.1±1.9 (range 1–16) days. Fluid collection was detected in the gallbladder area in 67 patients (26.8%). The mean volume of collected fluid was 8.8±5.2 mL. There were no significant effects of age, gender, and previous cholecystitis attacks on the presence or volume of the fluid collection (P>0.05 for all). With regard to the relationship between fluid collection and drains, 52 of 199 (26.1%) patients without drains had postoperative fluid collec- tion, compared to 15 of 51 (29.4%) patients with drains (P>0.05). Conclusion: In conclusion, there is no relationship between the presence of a drain after laparoscopic cholecystectomy and the presence of postoperative fluid collection. Thus, in patients without complications, it is not necessary to place a drain to prevent fluid collection.