Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension

Kaya, Hasan; ÜLGEN, Mehmet Sıddık; ATILGAN, Zuhal; Yüksel, Murat; YILDIZ, Abdulkadir; ERTAŞ, Faruk; OYLUMLU, Mustafa; BİLLİK, Mehmet Zihni; POLAT, Nihat; AKIL, Mehmet Ata

Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension

Abdulkadir YILDIZ, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Hasan KAYA, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Faruk ERTAŞ, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Mustafa OYLUMLU, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Mehmet Zihni BİLLİK, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Murat YÜKSEL, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Nihat POLAT, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Mehmet Ata AKIL, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Zuhal ATILGAN, (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Mehmet Sıddık ÜLGEN (Dicle Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Diyarbakır Türkiye)

Türk Kardiyoloji Derneği Arşivi

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Yıl: 2013 Cilt: 41 Sayı: 7 Sayfa Aralığı: 604 - 609 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension

Öz:

Amaç: Pulmoner hipertansiyon (PH) sağ ventrikül yetersizliği ve yüksek mortalite ile seyreden artmış pulmoner arter direnci ile kendini gösteren heterojen bir hastalık grubundan oluşur. Son zamanlarda patofizyolojik mekanizmada enflamasyonun merkezi bir rolü olduğu ile ilgili kanıtlar artmaktadır. Sistemik enflamatuvar hastalıklarda PH prevalansının artmış olduğu zaten bilinmektedir. Bu çalışmada, nötrofil/lenfosit oranı (N/L oranı) ile pulmoner arter hipertansiyonu (PAH) arasındaki ilişki değerlendirildi.Çalışma planı: Pulmoner arter hipertansiyonu bulunan 25 hasta ve sağlıklı 25 gönüllüden oluşan kontrol grubu değerlendirildi. Bazal klinik ve ekokardiyografik bulgular kaydedildi. Tüm hasta ve kontrol grubunun tam kan sayımları geriye dönük olarak değerlendirildi. Bulgular: Nötrofil/lenfosit oranı kontrol grubuna göre PAHlı hastalarda daha yüksekti (p=0.05). N/L oranının 1.65 eşik değeri PAH varlığını %72 duyarlılık ve %69 özgüllük ile öngörmekteydi. Çok değişkenli analizden sonra sadece N/L oranının PAHın anlamlı öngördürücüsü olarak kaldığı saptandı.Sonuç: Nötrofil/lenfosit oranının kontrol grubuna göre PAHlı hastalarda daha yüksek olduğu gösterildi.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Nötrofil/lenfosit oranı ile pulmoner arter hipertansiyonu arasındaki ilişki

Öz:

Objectives: Pulmonary hypertension (PH) is composed of a heterogeneous group of disorders marked by increased pul- monary artery resistance leading to right heart failure, with high mortality. Evidence is increasing to propose that inflam- mation plays a significant role in the pathophysiological mech- anism. Increased prevalence of PH in patients with systemic inflammatory diseases is already known. Herein, we sought to evaluate the association between neutrophil to lymphocyte ratio (N/L ratio) and pulmonary arterial hypertension (PAH). Study design: Twenty-five patients with PAH and 25 controls were evaluated. Baseline clinical and echocardiographic vari- ables were obtained. Complete blood counts in all patients and controls were reviewed retrospectively. Results: The N/L ratio was higher in patients with PAH com- pared to healthy volunteers (p=0.05). A cut-off value of 1.65 for N/L ratio predicted the presence of PAH with 72% sensitiv- ity and 69% specificity. After multivariate analysis, only N/L ratio remained a significant predictor of PAH. Conclusion: We showed for the first time that N/L ratio was significantly increased in patients with PAH compared to con- trols.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	YILDIZ A, Kaya H, ERTAŞ F, OYLUMLU M, BİLLİK M, Yüksel M, POLAT N, AKIL M, ATILGAN Z, ÜLGEN M (2013). Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension. , 604 - 609.
Chicago	YILDIZ Abdulkadir,Kaya Hasan,ERTAŞ Faruk,OYLUMLU Mustafa,BİLLİK Mehmet Zihni,Yüksel Murat,POLAT Nihat,AKIL Mehmet Ata,ATILGAN Zuhal,ÜLGEN Mehmet Sıddık Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension. (2013): 604 - 609.
MLA	YILDIZ Abdulkadir,Kaya Hasan,ERTAŞ Faruk,OYLUMLU Mustafa,BİLLİK Mehmet Zihni,Yüksel Murat,POLAT Nihat,AKIL Mehmet Ata,ATILGAN Zuhal,ÜLGEN Mehmet Sıddık Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension. , 2013, ss.604 - 609.
AMA	YILDIZ A,Kaya H,ERTAŞ F,OYLUMLU M,BİLLİK M,Yüksel M,POLAT N,AKIL M,ATILGAN Z,ÜLGEN M Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension. . 2013; 604 - 609.
Vancouver	YILDIZ A,Kaya H,ERTAŞ F,OYLUMLU M,BİLLİK M,Yüksel M,POLAT N,AKIL M,ATILGAN Z,ÜLGEN M Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension. . 2013; 604 - 609.
IEEE	YILDIZ A,Kaya H,ERTAŞ F,OYLUMLU M,BİLLİK M,Yüksel M,POLAT N,AKIL M,ATILGAN Z,ÜLGEN M "Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension." , ss.604 - 609, 2013.
ISNAD	YILDIZ, Abdulkadir vd. "Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension". (2013), 604-609.

APA	YILDIZ A, Kaya H, ERTAŞ F, OYLUMLU M, BİLLİK M, Yüksel M, POLAT N, AKIL M, ATILGAN Z, ÜLGEN M (2013). Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension. Türk Kardiyoloji Derneği Arşivi, 41(7), 604 - 609.
Chicago	YILDIZ Abdulkadir,Kaya Hasan,ERTAŞ Faruk,OYLUMLU Mustafa,BİLLİK Mehmet Zihni,Yüksel Murat,POLAT Nihat,AKIL Mehmet Ata,ATILGAN Zuhal,ÜLGEN Mehmet Sıddık Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension. Türk Kardiyoloji Derneği Arşivi 41, no.7 (2013): 604 - 609.
MLA	YILDIZ Abdulkadir,Kaya Hasan,ERTAŞ Faruk,OYLUMLU Mustafa,BİLLİK Mehmet Zihni,Yüksel Murat,POLAT Nihat,AKIL Mehmet Ata,ATILGAN Zuhal,ÜLGEN Mehmet Sıddık Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension. Türk Kardiyoloji Derneği Arşivi, vol.41, no.7, 2013, ss.604 - 609.
AMA	YILDIZ A,Kaya H,ERTAŞ F,OYLUMLU M,BİLLİK M,Yüksel M,POLAT N,AKIL M,ATILGAN Z,ÜLGEN M Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension. Türk Kardiyoloji Derneği Arşivi. 2013; 41(7): 604 - 609.
Vancouver	YILDIZ A,Kaya H,ERTAŞ F,OYLUMLU M,BİLLİK M,Yüksel M,POLAT N,AKIL M,ATILGAN Z,ÜLGEN M Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension. Türk Kardiyoloji Derneği Arşivi. 2013; 41(7): 604 - 609.
IEEE	YILDIZ A,Kaya H,ERTAŞ F,OYLUMLU M,BİLLİK M,Yüksel M,POLAT N,AKIL M,ATILGAN Z,ÜLGEN M "Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension." Türk Kardiyoloji Derneği Arşivi, 41, ss.604 - 609, 2013.
ISNAD	YILDIZ, Abdulkadir vd. "Association between neutrophil to lymphocyte ratio and pulmonary arterial hypertension". Türk Kardiyoloji Derneği Arşivi 41/7 (2013), 604-609.