In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes

Büsra CEBECI KONCUK, (Hitit Üniversitesi, Alaca Meslek Yüksek Okulu Çorum, Türkiye)
Zuhal ALIM, (Atatürk Üniversitesi, Fen Fakültesi, Kimya Bölümü, Erzurum, Türkiye)
Şükrü BEYDEMİR (Atatürk Üniversitesi, Fen Fakültesi, Kimya Bölümü, Erzurum, Türkiye)
Turkish Journal of Chemistry
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Yıl: 2014 Cilt: 38 Sayı: 3 Sayfa Aralığı: 512 - 520 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes

Öz:
The organophosphate target enzyme paraoxonase-1 (PON1) has been extensively studied in toxicology. Pesticides are organophosphate compounds that are commonly used in agriculture. They are also used as nerve gases, such as sarin and soman. Therefore, the effects of these compounds on enzymatic activity are well known. In the present study, we investigated the in vitro effects of fenoxaprop-p-ethyl, lambda cyhalothrin, imidacloprid, and dichlorvos pesticides on sheep liver microsomal PON1. The enzyme was purified approximately 141-fold with a specific activity of 1822.22 EU/mg proteins. The pesticides inhibited sheep liver PON1 in vitro, and the IC 50 values for these compounds were 0.0103, 0.069, 0.157, and 0.2 μ M, respectively.
Anahtar Kelime:

Konular: Mühendislik, Kimya
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA CEBECI KONCUK B, ALIM Z, BEYDEMİR Ş (2014). In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes. , 512 - 520.
Chicago CEBECI KONCUK Büsra,ALIM ZUHAL,BEYDEMİR Şükrü In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes. (2014): 512 - 520.
MLA CEBECI KONCUK Büsra,ALIM ZUHAL,BEYDEMİR Şükrü In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes. , 2014, ss.512 - 520.
AMA CEBECI KONCUK B,ALIM Z,BEYDEMİR Ş In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes. . 2014; 512 - 520.
Vancouver CEBECI KONCUK B,ALIM Z,BEYDEMİR Ş In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes. . 2014; 512 - 520.
IEEE CEBECI KONCUK B,ALIM Z,BEYDEMİR Ş "In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes." , ss.512 - 520, 2014.
ISNAD CEBECI KONCUK, Büsra vd. "In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes". (2014), 512-520.
APA CEBECI KONCUK B, ALIM Z, BEYDEMİR Ş (2014). In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes. Turkish Journal of Chemistry, 38(3), 512 - 520.
Chicago CEBECI KONCUK Büsra,ALIM ZUHAL,BEYDEMİR Şükrü In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes. Turkish Journal of Chemistry 38, no.3 (2014): 512 - 520.
MLA CEBECI KONCUK Büsra,ALIM ZUHAL,BEYDEMİR Şükrü In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes. Turkish Journal of Chemistry, vol.38, no.3, 2014, ss.512 - 520.
AMA CEBECI KONCUK B,ALIM Z,BEYDEMİR Ş In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes. Turkish Journal of Chemistry. 2014; 38(3): 512 - 520.
Vancouver CEBECI KONCUK B,ALIM Z,BEYDEMİR Ş In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes. Turkish Journal of Chemistry. 2014; 38(3): 512 - 520.
IEEE CEBECI KONCUK B,ALIM Z,BEYDEMİR Ş "In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes." Turkish Journal of Chemistry, 38, ss.512 - 520, 2014.
ISNAD CEBECI KONCUK, Büsra vd. "In vitro effects of pesticide exposure on the activity of the paraoxonase-1 enzyme from sheep liver microsomes". Turkish Journal of Chemistry 38/3 (2014), 512-520.
Sayfa Oluşturulma Tarihi
22-04-2024 20:25

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