Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome

Somuk, Battal Tahsin; EYİBİLEN, Ahmet; GÜRBÜZLER, Levent; soyalıç, harun; Dogru, Serkan; GÖKTAŞ, Göksel

Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome

Harun SOYALIÇ, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz Hastalıkları Anabilim Dalı, Tokat, Türkiye)

Battal Tahsin SOMUK, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz Hastalıkları Anabilim Dalı, Tokat, Türkiye)

Serkan DOĞRU, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz Hastalıkları Anabilim Dalı, Tokat, Türkiye)

Levent GÜRBÜZLER, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz Hastalıkları Anabilim Dalı, Tokat, Türkiye)

Göksel GÖKTAŞ, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz Hastalıkları Anabilim Dalı, Tokat, Türkiye)

Ahmet EYİBİLEN (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Kulak Burun Boğaz Hastalıkları Anabilim Dalı, Tokat, Türkiye)

Kulak Burun Boğaz İhtisas Dergisi

2 0

Yıl: 2015 Cilt: 25 Sayı: 1 Sayfa Aralığı: 16 - 21 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome

Öz:

Amaç: Bu çalışmada çocuklarda adenotonsiller hipertrofinin neden olduğu tıkayıcı uyku apne sendromu (TUAS) ile ortalama trombosit hacmi (OTH) ve OTH/trombosit sayısı oranı arasındaki ilişki belirlendi ve adenotonsillektominin bu iki parametre üzerindeki etkisi değerlendirildi. Hastalar ve Yöntemler: Bu prospektif çalışmaya Ocak 2011 - Ocak 2013 tarihleri arasında Gaziosmanpaşa Üniversitesi Tıp Fakültesi Hastanesi Kulak Burun Boğaz Polikliniğine tanıklı apne ve horlama nedeni ile başvuran, kronik adenotonsiller hipertrofisi olan 73 çocuk hasta (38 erkek, 35 kız; ort. yaş 8.6±3.3 yıl; dağılım 2-17 yıl) dahil edildi. Ayrıca kliniğimize TUAS dışı nedenlerle başvuran, yaş ve cinsiyet uyumlu 56 çocuk hasta (28 erkek, 26 kız; ort. yaş 8.0±3.2 yıl; dağılım 3-13 yıl) kontrol grubu olarak çalışmaya alındı. Hastaların ameliyat öncesinde ve ameliyat sonrası üçüncü ayda hemoglobin, beyaz kan hücresi, trombosit sayısı ve OTH değerleri kaydedildi. Bulgular: Hasta grubunda OTH/trombosit sayısı oranı kontrol grubuna göre yüksek olsa da fark istatistiksel olarak anlamlı değildi. Ortalama trombosit hacmi düzeyi hasta grubunda 7.68±1.07 fL, kontrol grubunda 7.21±0.84 fL idi. Ameliyat öncesi OTH düzeyi hasta grubunda kontrol grubundan anlamlı olarak yüksekti (p<0.05). Ameliyat sonrası üçüncü aydaki OTH düzeyi ve trombosit sayısında ameliyat öncesi OTH düzeyi ve trombosit sayısına göre istatistiksel olarak anlamlı bir azalma saptandı (sırasıyla, 7.68±1.07 fL; 7.17±0.97 fL; p<0.05). Sonuç: Adenotonsiller hipertrofili çocuklarda yüksek OTH ve OTH/trombosit sayısı, hem çocukluk hem de yetişkin dönemde gelişebilen kardiopulmoner ve serebrovasküler morbiditeler için önemli bir risk faktörü olabilir. Adenotonsillektomi bu riski anlamlı olarak azaltabilir.

Anahtar Kelime:

Konular: Cerrahi

count in children with obstructive sleep apnea syndrome Tıkayıcı uyku apne sendromu olan çocuklarda ortalama trombosit hacmi ve ortalama trombosit hacminin trombosit sayısına oranının değerlendirilmesi

Öz:

Objectives: This study aims to determine the association between obstructive sleep apnea syndrome (OSAS) caused by adenotonsillar hypertrophy and mean platelet volume (MPV) and MPV/platelet count ratio in children, and to evaluate the impact of adenotonsillectomy on these two parameters. Patients and Methods: This prospective study consisted of 73 child patients (38 boys, 35 girls; mean age 8.6±3.3 years, range 2 to 17 years) with chronic adenotonsillar hypertrophy who applied to Gaziosmanpaşa University Faculty of Medicine, Ear, Nose and Throat policlinics due to witnessed apnea and snoring in January 2011 and January 2013. Also, 56 age and sex matched pediatric patients (28 boys, 26 girls; mean age 8.0±3.2 years; range 3 to 13 years) who admitted to our clinic due to reasons besides OSAS were included in the study as control group. Preoperative and postoperative third month hemoglobin, white blood cell, thrombocyte count, and MPV values of the patients were recorded. Results: Although ratio of MPV/platelet count was higher in patient group than in control group, the difference was not statistically significant. Mean platelet volume level was 7.68±1.07 fL in patient group and 7.21±0.84 fL in control group. Preoperative MPV level in patient group was significantly higher than that in control group (p<0.05). A statistically significant decrease was detected in postoperative third month MPV level and platelet count compared with preoperative MPV and platelet count (7.68±1.07 fL and 7.17±0.97 fL, respectively; p<0.05). Conclusion: High MPV and MPV/platelet count in children with adenotonsillar hypertrophy may be an important risk factor for cardiopulmonary and cerebrovascular morbidities which may develop both in childhood and in adulthood. Adenotonsillectomy may reduce this risk significantly.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	soyalıç h, Somuk B, Dogru S, GÜRBÜZLER L, GÖKTAŞ G, EYİBİLEN A (2015). Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome. , 16 - 21.
Chicago	soyalıç harun,Somuk Battal Tahsin,Dogru Serkan,GÜRBÜZLER Levent,GÖKTAŞ Göksel,EYİBİLEN Ahmet Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome. (2015): 16 - 21.
MLA	soyalıç harun,Somuk Battal Tahsin,Dogru Serkan,GÜRBÜZLER Levent,GÖKTAŞ Göksel,EYİBİLEN Ahmet Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome. , 2015, ss.16 - 21.
AMA	soyalıç h,Somuk B,Dogru S,GÜRBÜZLER L,GÖKTAŞ G,EYİBİLEN A Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome. . 2015; 16 - 21.
Vancouver	soyalıç h,Somuk B,Dogru S,GÜRBÜZLER L,GÖKTAŞ G,EYİBİLEN A Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome. . 2015; 16 - 21.
IEEE	soyalıç h,Somuk B,Dogru S,GÜRBÜZLER L,GÖKTAŞ G,EYİBİLEN A "Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome." , ss.16 - 21, 2015.
ISNAD	soyalıç, harun vd. "Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome". (2015), 16-21.

APA	soyalıç h, Somuk B, Dogru S, GÜRBÜZLER L, GÖKTAŞ G, EYİBİLEN A (2015). Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome. Kulak Burun Boğaz İhtisas Dergisi, 25(1), 16 - 21.
Chicago	soyalıç harun,Somuk Battal Tahsin,Dogru Serkan,GÜRBÜZLER Levent,GÖKTAŞ Göksel,EYİBİLEN Ahmet Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome. Kulak Burun Boğaz İhtisas Dergisi 25, no.1 (2015): 16 - 21.
MLA	soyalıç harun,Somuk Battal Tahsin,Dogru Serkan,GÜRBÜZLER Levent,GÖKTAŞ Göksel,EYİBİLEN Ahmet Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome. Kulak Burun Boğaz İhtisas Dergisi, vol.25, no.1, 2015, ss.16 - 21.
AMA	soyalıç h,Somuk B,Dogru S,GÜRBÜZLER L,GÖKTAŞ G,EYİBİLEN A Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome. Kulak Burun Boğaz İhtisas Dergisi. 2015; 25(1): 16 - 21.
Vancouver	soyalıç h,Somuk B,Dogru S,GÜRBÜZLER L,GÖKTAŞ G,EYİBİLEN A Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome. Kulak Burun Boğaz İhtisas Dergisi. 2015; 25(1): 16 - 21.
IEEE	soyalıç h,Somuk B,Dogru S,GÜRBÜZLER L,GÖKTAŞ G,EYİBİLEN A "Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome." Kulak Burun Boğaz İhtisas Dergisi, 25, ss.16 - 21, 2015.
ISNAD	soyalıç, harun vd. "Evaluation of mean platelet volume and its ratio over platelet count in children with obstructive sleep apnea syndrome". Kulak Burun Boğaz İhtisas Dergisi 25/1 (2015), 16-21.