Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury

AYDIN, Varol; göçmen, ayşe yeşim; SERTER, Mukadder; AK, Hakan; YALÇIN, Sercan Savaş

Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury

Sercan Savaş YALÇIN, (Sağlık Bakanlığı, Erzurum Bölge Eğitim ve Araştırma Hastanesi, Nöroşirürji Kliniği, Erzurum, Türkiye)

Hakan AK, (Bozok Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Yozgat, Türkiye)

Varol AYDIN, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Aydın, Türkiye)

Mukadder SERTER, (Adnan Menderes Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Aydın, Türkiye)

Ayşe Yeşim GÖÇMEN (Bozok Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Yozgat, Türkiye)

Journal of Neurological Sciences (Turkish)

6 3

Yıl: 2013 Cilt: 30 Sayı: 4 Sayfa Aralığı: 651 - 659 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury

Öz:

Amaç: Bu çalışmanın amacı akut periferik sinir hasarında yerel kan akımını artırıcı etkiyesahip olan nikergolinin akut dönemdeki etkilerinin incelenmesidir.Yöntem ve gereçler: Çalışma ağırlıkları 200-250 gram arasında değişen Wistar albino cinsisıçanlarda orta basınçı anevrizma klibi ile periferik sinir hasarı oluşturularak yapılmıştır. Sıçanlar her bir grupta 10 denek olacak şekilde dört gruba ayrıldı. Birinci grup kontrol grubuolup, bu grupta sadece siyatik sinir disseksiyonu yapıldı. Ikinci grupta siyatik sinirdisseksiyonunu takiben klip ile sinir hasarı oluşturuldu. Üçüncü grupta sinir hasarıoluşturulduktan sonra 7 gün boyunca düşük doz nikergolin verildi. Dördüncü grupta ise hasarsonrası 7 gün boyunca yüksek doz nikergolin verildi. Sıçanlar sekizinci gün denekler yürümetestine tabi tutularak siyatik sinir fonksiyonel endeksleri hesaplandı. Sonrasında deneklerinsiyatik sinir dokuları alındı ve bu dokularda interlökin-10, miyeloperoksidaz, tümörnekrotizan faktör, sinir büyüme faktörü ve malondialdehid düzeyleri bakıldı. İstatikselanalizde Mann-Whitney U testi kullanıldı. İstatiksel olarak 0,05'den küçük değerler anlamlıolarak kabul edildi.Sonuçlar: Siyatik sinir fonksiyonel endeksi tüm gruplar arasında istatiksel olarak anlamlıfarklılık gösterdi. Doku interlökin-10 düzeyi grup III ve IV arasında hariç olmak üzere tümgruplar arasında anlamlı farklılık gösterdi. Doku tümör nekrotizan faktör alfa,miyeloperoksidaz, malondialdehid ve sinir büyüme faktörü düzeyleri tüm gruplar arasındaanlamlı farklılık gösterdi.Tartışma: Nikergolin akut periferik sinir hasarının tedavisinde akut dönemde istatiksel olarakanlamlı düzeyde iyileştirici etki göstermiştir.Sonuç: Nikergolin özellikle cerrahi için aday olamayan hastalarda periferik sinir hasarınıntedavisinde kullanılabilir. Bununla birlikte, bu çalışmanın histopatolojik destekli ekçalışmalarla desteklenmesi gerekmektedir.

Anahtar Kelime:

Konular: Nörolojik Bilimler

Akut Periferik Sinir Yaralanmasının Tedavisinde Nikergolinin Akut Dönem Etkilerinin Değerlendirilmesi

Öz:

Purpose: The purpose of this study is to evaluate the acute period effects of nicergoline, hasan effect on increasing local blood flow, in the management of acute peripheral nerve injury.Materials and methods: Study was performed on Wistar albino rats weighing about 200-250grams by developing sciatic nerve injury with medium pressured smooth aneurysm clip. Ratsdivided into four groups each containing ten animals. In the first group, only sciatic nervedissection was performed, control group. In second group, sciatic nerve injury was performedand animals were leaved to spontaneous healing. In the third group, after performing sciaticnerve injury rats were given low-dose nicergoline for 7 days. In the fourth group, after sciaticnerve injury rats were given high dose nicergoline for 7 days. Before sacrification, for theassessing of sciatic nerve functional index, walking track analysis was performed. In thesciatic nerve tissue samples, interleukin-10, myeloperoxidase, tumor necrosis factor alpha,nerve growth factor, malondialdehyde levels were measured. For the statistical analysis,Mann-Whitney U test was used and the values lesser than 0.05 was accepted as statisticallysignificant.Results: Sciatic nerve functional index showed statistically significant difference between allgroups. Tissue interleukin-10 levels showed significant differences between all groups exceptgroup III and IV. Tissue tumor necrosis factor-α, myeloperoxidase, malondialdehyde, andnerve growth factor levels showed significant differences between all groups.Discussion: Nicergoline showed statistically significant effects in the management of acuteperipheral nerve injury at the acute period.Conclusion: Nicergoline may be used in the management of peripheral nerve injuries,especially in the cases that are not good candidates for surgery, at least as an adjuvant therapy.However, this study must be supported by new ones having histopathological bases.

Anahtar Kelime:

Konular: Nörolojik Bilimler

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	YALÇIN S, AK H, AYDIN V, SERTER M, göçmen a (2013). Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury. , 651 - 659.
Chicago	YALÇIN Sercan Savaş,AK Hakan,AYDIN Varol,SERTER Mukadder,göçmen ayşe yeşim Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury. (2013): 651 - 659.
MLA	YALÇIN Sercan Savaş,AK Hakan,AYDIN Varol,SERTER Mukadder,göçmen ayşe yeşim Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury. , 2013, ss.651 - 659.
AMA	YALÇIN S,AK H,AYDIN V,SERTER M,göçmen a Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury. . 2013; 651 - 659.
Vancouver	YALÇIN S,AK H,AYDIN V,SERTER M,göçmen a Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury. . 2013; 651 - 659.
IEEE	YALÇIN S,AK H,AYDIN V,SERTER M,göçmen a "Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury." , ss.651 - 659, 2013.
ISNAD	YALÇIN, Sercan Savaş vd. "Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury". (2013), 651-659.

APA	YALÇIN S, AK H, AYDIN V, SERTER M, göçmen a (2013). Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury. Journal of Neurological Sciences (Turkish), 30(4), 651 - 659.
Chicago	YALÇIN Sercan Savaş,AK Hakan,AYDIN Varol,SERTER Mukadder,göçmen ayşe yeşim Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury. Journal of Neurological Sciences (Turkish) 30, no.4 (2013): 651 - 659.
MLA	YALÇIN Sercan Savaş,AK Hakan,AYDIN Varol,SERTER Mukadder,göçmen ayşe yeşim Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury. Journal of Neurological Sciences (Turkish), vol.30, no.4, 2013, ss.651 - 659.
AMA	YALÇIN S,AK H,AYDIN V,SERTER M,göçmen a Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury. Journal of Neurological Sciences (Turkish). 2013; 30(4): 651 - 659.
Vancouver	YALÇIN S,AK H,AYDIN V,SERTER M,göçmen a Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury. Journal of Neurological Sciences (Turkish). 2013; 30(4): 651 - 659.
IEEE	YALÇIN S,AK H,AYDIN V,SERTER M,göçmen a "Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury." Journal of Neurological Sciences (Turkish), 30, ss.651 - 659, 2013.
ISNAD	YALÇIN, Sercan Savaş vd. "Evaluation of the Acute Period Effects of Nicergoline in the Management of Acute Peripheral Nerve Injury". Journal of Neurological Sciences (Turkish) 30/4 (2013), 651-659.