The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients

Eren, Mehmet; kukul guven, fatma mutlu; EREN, Şevki Hakan; Aydin, Huseyin; beydilli, inan; Korkmaz, İlhan; YILDIRIM, BİRDAL

The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients

İlhan KORKMAZ, (Cumhuriyet Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Sivas, Türkiye)

Hüseyin AYDIN, (Cumhuriyet Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Sivas, Türkiye)

Şevki Hakan EREN, (Cumhuriyet Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Sivas, Türkiye)

FATMA MUTLU KUKUL GÜVEN, (Cumhuriyet Üniversitesi, Tıp Fakültesi, Acil Tıp Anabilim Dalı, Sivas, Türkiye)

Birdal YILDIRIM, (Sağlık Bakanlığı, Marmaris Devlet Hastanesi, Acil Servisi, Muğla, Türkiye)

İnan BEYDİLLİ, (SB Antalya Eğitim ve Araştırma Hastanesi, Acil Tıp Kliniği, Antalya, Türkiye)

Mehmet EREN (Ankara Atatürk Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Kliniği, Ankara, Türkiye)

Journal of Clinical and Analytical Medicine

1 1

Yıl: 2013 Cilt: 4 Sayı: 3 Sayfa Aralığı: 196 - 199 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients

Öz:

Amaç: Travma hastalarının prognozunun takibinde şok indeksi ve glaskowkoma skalası (GKS) kullanılan parametrelerdir. Travma durumunda artan reaktif oksijen türlerine ve oksidatif strese bağlı olarak hücrelerde lipid peroksidasyonunda artma ve hücre duvar yapısındaki bozulmalara bağlı olarak hücre ve doku hasarı görülür. Bu çalışmada hastaların başvuru anındaki oksidatif stres düzeyleri ile antioksidan olan paraoksanazın prognozla ilişkisini araştırdık. Gereç ve Yöntem: Çalışmaya Temmuz-Eylül 2011 tarihlerinde başvuran 71 travma hastası dahil edildi. Hastalar GKSuna göre hafif(61), orta(6)ve ağır olarak(3) sınıflandırıldı. Paraoksanaz, oksidatif stres indeksi (OSİ), total antioksidan kapasite (TAS) ve toplam oksidatif stres (TOS) ile şok indeksive GKS ile karşılaştırıldı. Bulgular: Çalışma sonunda paraoksanaz, TAS, TOS,OSİ, ile GKS yönünden gruplar arası farklılık görülmedi (p>0.05). Şok indeksi ile paraoksanaz, TAS, TOS, OSİ arasında korelasyon analiz yapıldığında birkorelasyon gözlenmedi. Sonuç: Yaptığımız çalışma sonunda başvuru anındaki oksidatif stres parametreleri ile antioksidan olan paraoksanazın hastalarıntravma şiddeti ile korelasyonunun olmadığı sonucuna vardık.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Künt Travma Hastalarında Oksidatif Stres ve Paraoksanaz Düzeyleri ile Travma Şiddetinin Karşılaştırılması

Öz:

Aim: Shock index and Glascow coma scale(GCS) are the parametersused for the follow-up of trauma patient s prognosis. In case of traumaincreased reactive oxygen species and oxidative stres induced increase inlipid peroxidation causes deterioration of the cell wall structure, and anincrease of cell and tissue damage can be seen. We aimed to investigate therelationship between oxidative stress and paraoxonase, as an antioxidant,and prognosis of the trauma patients. Material and Method: Seventyonetrauma patients who were admitted between July - September 2011 wereincluded. Patients were classified according to GCS; Mild (61), moderate (6),and severe (3). Paraoxonase, oxidative stress index (OSI), total antioxidantcapacity (TAC) and total oxidative stress (TOS) were compared with theshock index and the GCS. Results: We didn t found any difference betweenGCS groups and paraoxonase, TAS, TOS, OSI (p> 0.05). Also there wasn t anycorrelation between shock index and paraoxonase, TAC, TOS, OSI. Discussion:We make inferences that the admission levels of paraoxonase, TAC, TOS, OSIcan t be used for determination of the trauma patients prognosis.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Korkmaz İ, Aydin H, EREN Ş, kukul guven f, YILDIRIM B, beydilli i, Eren M (2013). The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients. , 196 - 199.
Chicago	Korkmaz İlhan,Aydin Huseyin,EREN Şevki Hakan,kukul guven fatma mutlu,YILDIRIM BİRDAL,beydilli inan,Eren Mehmet The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients. (2013): 196 - 199.
MLA	Korkmaz İlhan,Aydin Huseyin,EREN Şevki Hakan,kukul guven fatma mutlu,YILDIRIM BİRDAL,beydilli inan,Eren Mehmet The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients. , 2013, ss.196 - 199.
AMA	Korkmaz İ,Aydin H,EREN Ş,kukul guven f,YILDIRIM B,beydilli i,Eren M The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients. . 2013; 196 - 199.
Vancouver	Korkmaz İ,Aydin H,EREN Ş,kukul guven f,YILDIRIM B,beydilli i,Eren M The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients. . 2013; 196 - 199.
IEEE	Korkmaz İ,Aydin H,EREN Ş,kukul guven f,YILDIRIM B,beydilli i,Eren M "The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients." , ss.196 - 199, 2013.
ISNAD	Korkmaz, İlhan vd. "The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients". (2013), 196-199.

APA	Korkmaz İ, Aydin H, EREN Ş, kukul guven f, YILDIRIM B, beydilli i, Eren M (2013). The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients. Journal of Clinical and Analytical Medicine, 4(3), 196 - 199.
Chicago	Korkmaz İlhan,Aydin Huseyin,EREN Şevki Hakan,kukul guven fatma mutlu,YILDIRIM BİRDAL,beydilli inan,Eren Mehmet The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients. Journal of Clinical and Analytical Medicine 4, no.3 (2013): 196 - 199.
MLA	Korkmaz İlhan,Aydin Huseyin,EREN Şevki Hakan,kukul guven fatma mutlu,YILDIRIM BİRDAL,beydilli inan,Eren Mehmet The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients. Journal of Clinical and Analytical Medicine, vol.4, no.3, 2013, ss.196 - 199.
AMA	Korkmaz İ,Aydin H,EREN Ş,kukul guven f,YILDIRIM B,beydilli i,Eren M The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients. Journal of Clinical and Analytical Medicine. 2013; 4(3): 196 - 199.
Vancouver	Korkmaz İ,Aydin H,EREN Ş,kukul guven f,YILDIRIM B,beydilli i,Eren M The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients. Journal of Clinical and Analytical Medicine. 2013; 4(3): 196 - 199.
IEEE	Korkmaz İ,Aydin H,EREN Ş,kukul guven f,YILDIRIM B,beydilli i,Eren M "The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients." Journal of Clinical and Analytical Medicine, 4, ss.196 - 199, 2013.
ISNAD	Korkmaz, İlhan vd. "The Relationship Between Oxidative Stress, Paraoxanase and Injury Severity in Blunt Trauma Patients". Journal of Clinical and Analytical Medicine 4/3 (2013), 196-199.