The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits
Yıl: 2016 Cilt: 22 Sayı: 5 Sayfa Aralığı: 801 - 803 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits
Öz: Bu çalışmada tavşanlarda 5 mg/kg (XYL-5) ve 10 mg/kg (XYL-10) dozlarda uygulanan Ksilazin HCl'ün intraoküler basınç üzerine etkilerinin belirlenmesi amaçlandı. İntraoküler basınç ölçümleri Ksilazin HCl uygulamasını takiben bazal (T-1), 5 (T5), 10 (T10), 15 (T15), 20 (T20), 30 (T30), 45 (T45) ve 60 (T60) dakikalarda yapıldı. Grup XYL-5'te T15 (8.37±1.45 mm Hg) ve grup XYL-10'da T5'te (8.00±1.13 mm Hg) önemli derecede IOP ölçümlerinin azaldığı belirlendi. Sonuç olarak, doza bakılmaksızın Ksilazin HCl, uygulamadan en geç 15 dakika sonra Beyaz Yeni Zelanda tavşanlarında intraoküler basıncı düşürdü.
Anahtar Kelime: Konular:
Farklı Dozlarda Uygulanan Ksilazin HCl'ün Tavşanlarda İntraoküler Basınç Üzerine Etkisi
Öz: This study was aimed to determine the effects of intramuscular Xylazine HCl administration on intraocular pressure (IOP) in rabbits at 5 mg/kg (XYL-5) and 10 mg/kg (XYL-10) doses. IOP measurements were recorded at baseline (T-1), and at 5 (T5), 10 (T10), 15 (T15), 20 (T20), 30 (T30), 45 (T45) and 60 (T60) minutes following Xylazine HCl administration. IOP values were significantly decreased at T15 in group XYL5 (8.37±1.45 mm Hg) and at T5 in group XYL-10 (8.00±1.13 mm Hg). In conclusion, intramuscular Xylazine HCl significantly reduced IOP in rabbits at the latest after 15 minutes of administration, regardless of the doses used in this study.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Yanmaz LE, Dogan E, Okumus Z, Senocak MG, Prastiwi A, Yildirim F: Xylazine-ketamine anesthesia following premedication of New Zealand white rabbits with Vitamin C. Kafkas Univ Vet Fak Derg, 22, 115-118, 2016. DOI: 10.9775/kvfd. 2015.13998
- Borkowski GL, Danneman PJ, Russell GB: An evaluation of three intravenous anesthetic regimens in New Zealand rabbits. Lab Anim Sci, , 270-276, 1990.
- Yershov AL, Jordan BS, Fudge JM, Dubick MA: Influence of the mode of ventilation on ketamine/xylazine requirements in rabbits. Vet Anaesth Analg, 34, 157-163, 2007. DOI: 10.1111/j.1467-2995.2006.00315.x
- Arthur S, Cantor LB: Update on the role of alpha-agonists in glaucoma management. Exp Eye Res, 93, 271-283, 2011. DOI: 10.1016/j. exer.2011.04.002
- Moon CH, Choi KS, Rhee MR, Lee SJ: Intraoperative assessment of intraocular pressure in vitrectomized air-filled and fluid-filled eyes. Acta Ophthalmol, 91, 524-528, 2013. DOI: 10.1111/aos.12145
- Holve DL, Gum GG, Pritt SL: Effect of sedation with xylazine and ketamine on intraocular pressure in New Zealand white rabbits. J Am Assoc Lab Anim Sci, 2, 488-490, 2013.
- Burke JA, Potter DE: The ocular effects of xylazine in rabbits, cats and monkeys. J Ocul Pharmacol, 2, 9-21, 1986. DOI: 10.1089/jop.1986.2.9
- Trim CM, Colbern G, Martin C: Effect of xylazine and ketamine on intraocular pressure in horses. Vet Rec, 117, 442-443, 1985. DOI: 10.1136/ vr.117.17.442
- Hazra S, Palui H, Bhabatosh B, Konar A: Anesthesia for intraocular surgery in rabbits. Scan J Lab Anim Sci, 38, 81-87, 2011.
- Pereira FQ, Bercht BS, Soares MG, Da Mota MG, Pigatto JA: Comparison of a rebound and applanation tonometer for measuring intraocular pressure in normal rabbits. Vet Ophthalmol, 14, 321-326, 2011. DOI: 10.1111/j.1463-5224.2011.00879.x
- Kern JT: Rabbit and rodent ophthalmology. Semin Avian Exot Pet, 6, 145, 1997. DOI:10.1016/S1055-937X(97)80021-7
- Miyazaki Y, Matsuo T, Kurabayashi Y: Immobilization stress induces elevation of intraocular pressure in rabbits. Opthalmic Res, 32, 270-277, DOI: 10.1159/000055625
- Conour LA, Murray KA, Brown MJ: Preperation of animals for research-issues to consider for rodents and rabbits. Ilar J, 47, 283-293, DOI: 10.1093/ilar.47.4.283
- Kanda T, Iquchi A, Yoshioka C, Nomura H, Higashi K, Kaya M, Yamamoto R, Kuramoto T, Furukawa T: Effects of medetomidine and xylazine on intraocular pressure and pupil size in healthy Beagle dogs. Vet Anaesth Analg, 42, 623-628, 2015. DOI: 10.1111/vaa.12249
- Bogner B, Runge C, Strohmailer C, Trost A, Tockner B, Kiel JW, Schroedl F, Reitsamer HA: The effect of vasopressin on ciliary blood flow and aqueous flow. Invet Ophthalmol Vis Sci, 55, 396-403, 2014. DOI: 1167/iovs.13-13286
| APA | dogan e, Yanmaz L, ERSOZ U, SENOCAK M, Okumuş Z (2016). The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits. , 801 - 803. |
| Chicago | dogan elif,Yanmaz Latif Emrah,ERSOZ Ugur,SENOCAK MÜMIN GOKHAN,Okumuş Zafer The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits. (2016): 801 - 803. |
| MLA | dogan elif,Yanmaz Latif Emrah,ERSOZ Ugur,SENOCAK MÜMIN GOKHAN,Okumuş Zafer The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits. , 2016, ss.801 - 803. |
| AMA | dogan e,Yanmaz L,ERSOZ U,SENOCAK M,Okumuş Z The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits. . 2016; 801 - 803. |
| Vancouver | dogan e,Yanmaz L,ERSOZ U,SENOCAK M,Okumuş Z The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits. . 2016; 801 - 803. |
| IEEE | dogan e,Yanmaz L,ERSOZ U,SENOCAK M,Okumuş Z "The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits." , ss.801 - 803, 2016. |
| ISNAD | dogan, elif vd. "The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits". (2016), 801-803. |
| APA | dogan e, Yanmaz L, ERSOZ U, SENOCAK M, Okumuş Z (2016). The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 22(5), 801 - 803. |
| Chicago | dogan elif,Yanmaz Latif Emrah,ERSOZ Ugur,SENOCAK MÜMIN GOKHAN,Okumuş Zafer The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 22, no.5 (2016): 801 - 803. |
| MLA | dogan elif,Yanmaz Latif Emrah,ERSOZ Ugur,SENOCAK MÜMIN GOKHAN,Okumuş Zafer The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.22, no.5, 2016, ss.801 - 803. |
| AMA | dogan e,Yanmaz L,ERSOZ U,SENOCAK M,Okumuş Z The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2016; 22(5): 801 - 803. |
| Vancouver | dogan e,Yanmaz L,ERSOZ U,SENOCAK M,Okumuş Z The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2016; 22(5): 801 - 803. |
| IEEE | dogan e,Yanmaz L,ERSOZ U,SENOCAK M,Okumuş Z "The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 22, ss.801 - 803, 2016. |
| ISNAD | dogan, elif vd. "The Effect of Different Doses of Intramuscular Xylazine HCl Administration on Intraocular Pressure in Rabbits". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 22/5 (2016), 801-803. |
