Protective effect of vardenafil on ischemia reperfusion injury in rat ovary

KARA, OZLEM; PANDIR, DİLEK; baş, hatice; Kara, Mustafa

Protective effect of vardenafil on ischemia reperfusion injury in rat ovary

Hatice BAŞ, (Bozok Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, Yozgat, Türkiye)

Özlem KARA, (Bozok Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, Yozgat, Türkiye)

Mustafa KARA, (Bozok Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Yozgat, Türkiye)

Dilek PANDIR (Bozok Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, Yozgat, Türkiye)

Turkish Journal of Medical Sciences

2 1

Yıl: 2013 Cilt: 43 Sayı: 5 Sayfa Aralığı: 684 - 689 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Protective effect of vardenafil on ischemia reperfusion injury in rat ovary

Öz:

Aim: To investigate the effect of vardenafil on ischemia reperfusion (I/R) injury in rat ovary. Materials and methods: A total of 21 Wistar rats were divided into 3 groups. In group 1, ovary torsion was not performed and no drug was administered. In group 2, 1 h of ischemia and 2 h of reperfusion were performed and no drug was given. In group 3, 1 h of ischemia and 2 h of reperfusion were performed and 1 mg/kg vardenafil was administered after 30 min of ischemia. Right ovaries were surgically removed in all groups. Malondialdehyde (MDA) levels and activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were measured. Apoptosis protease-activating factor 1 (Apaf-1) was measured by using immunohistochemistry. Results: MDA level was significantly increased and SOD, CAT, and GPx activities were significantly decreased in group 2 compared to the other groups (P < 0.05). In light microscopic investigations, severe vascular congestion, edema, hemorrhage, and follicular degeneration were assessed in the ovary tissue. Ovarian tissue damage was higher in group 2 than group 3. Apaf-1 expression was stronger in group 2 than group 3. Conclusion: Vardenafil treatment seems to reduce microscopic histopathological changes, decrease Apaf-1 response, and alter oxidative stress in I/R injury in rat ovaries.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	baş h, KARA O, Kara M, PANDIR D (2013). Protective effect of vardenafil on ischemia reperfusion injury in rat ovary. , 684 - 689.
Chicago	baş hatice,KARA OZLEM,Kara Mustafa,PANDIR DİLEK Protective effect of vardenafil on ischemia reperfusion injury in rat ovary. (2013): 684 - 689.
MLA	baş hatice,KARA OZLEM,Kara Mustafa,PANDIR DİLEK Protective effect of vardenafil on ischemia reperfusion injury in rat ovary. , 2013, ss.684 - 689.
AMA	baş h,KARA O,Kara M,PANDIR D Protective effect of vardenafil on ischemia reperfusion injury in rat ovary. . 2013; 684 - 689.
Vancouver	baş h,KARA O,Kara M,PANDIR D Protective effect of vardenafil on ischemia reperfusion injury in rat ovary. . 2013; 684 - 689.
IEEE	baş h,KARA O,Kara M,PANDIR D "Protective effect of vardenafil on ischemia reperfusion injury in rat ovary." , ss.684 - 689, 2013.
ISNAD	baş, hatice vd. "Protective effect of vardenafil on ischemia reperfusion injury in rat ovary". (2013), 684-689.

APA	baş h, KARA O, Kara M, PANDIR D (2013). Protective effect of vardenafil on ischemia reperfusion injury in rat ovary. Turkish Journal of Medical Sciences, 43(5), 684 - 689.
Chicago	baş hatice,KARA OZLEM,Kara Mustafa,PANDIR DİLEK Protective effect of vardenafil on ischemia reperfusion injury in rat ovary. Turkish Journal of Medical Sciences 43, no.5 (2013): 684 - 689.
MLA	baş hatice,KARA OZLEM,Kara Mustafa,PANDIR DİLEK Protective effect of vardenafil on ischemia reperfusion injury in rat ovary. Turkish Journal of Medical Sciences, vol.43, no.5, 2013, ss.684 - 689.
AMA	baş h,KARA O,Kara M,PANDIR D Protective effect of vardenafil on ischemia reperfusion injury in rat ovary. Turkish Journal of Medical Sciences. 2013; 43(5): 684 - 689.
Vancouver	baş h,KARA O,Kara M,PANDIR D Protective effect of vardenafil on ischemia reperfusion injury in rat ovary. Turkish Journal of Medical Sciences. 2013; 43(5): 684 - 689.
IEEE	baş h,KARA O,Kara M,PANDIR D "Protective effect of vardenafil on ischemia reperfusion injury in rat ovary." Turkish Journal of Medical Sciences, 43, ss.684 - 689, 2013.
ISNAD	baş, hatice vd. "Protective effect of vardenafil on ischemia reperfusion injury in rat ovary". Turkish Journal of Medical Sciences 43/5 (2013), 684-689.