Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study

Dilek PANDIR, (Bozok Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, Yozgat, Türkiye)
Özlem KARA (Bozok Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, Yozgat, Türkiye)
Turkish Journal of Medical Sciences
2 0
Yıl: 2013 Cilt: 43 Sayı: 6 Sayfa Aralığı: 951 - 956 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study

Öz:
Aim: Bilberry is a natural antioxidant and has been utilized as a free radical scavenger to reverse the toxic effects of oxidative stress. The aim of this study was to investigate the effect of bilberry on cisplatin-induced toxic effects in rat kidney. Materials and methods: Twenty-one female Wistar-albino rats were randomly divided into 3 groups: group I (control), one dose of saline solution; group II (cisplatin), single dose of 7.5 mg/kg of cisplatin; group III (cisplatin + bilberry), single dose of 7.5 mg/kg of cisplatin and 10 days of bilberry treatment applied as 200 mg/kg of bilberry. Malondialdehyde (MDA) levels and activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were measured. Histopathologic damage to the kidney tissue was analyzed via light microscopic examination. Results: Severe necrosis, edema, hemorrhage, interstitial cell infiltration, vascular dilatation, glomerular atrophy, and tubular degeneration were observed in group II. SOD, CAT, and GPx activities were decreased and MDA levels were increased in the cisplatin group compared to the cisplatin + bilberry group, and the differences were statistically significant (P < 0.05). Kidney tissue damage was significantly higher in group II than in group III (P < 0.05). Conclusion: Bilberry is efficient in the treatment of cisplatin-induced kidney damage.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA PANDIR D, KARA O (2013). Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study. , 951 - 956.
Chicago PANDIR DİLEK,KARA OZLEM Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study. (2013): 951 - 956.
MLA PANDIR DİLEK,KARA OZLEM Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study. , 2013, ss.951 - 956.
AMA PANDIR D,KARA O Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study. . 2013; 951 - 956.
Vancouver PANDIR D,KARA O Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study. . 2013; 951 - 956.
IEEE PANDIR D,KARA O "Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study." , ss.951 - 956, 2013.
ISNAD PANDIR, DİLEK - KARA, OZLEM. "Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study". (2013), 951-956.
APA PANDIR D, KARA O (2013). Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study. Turkish Journal of Medical Sciences, 43(6), 951 - 956.
Chicago PANDIR DİLEK,KARA OZLEM Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study. Turkish Journal of Medical Sciences 43, no.6 (2013): 951 - 956.
MLA PANDIR DİLEK,KARA OZLEM Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study. Turkish Journal of Medical Sciences, vol.43, no.6, 2013, ss.951 - 956.
AMA PANDIR D,KARA O Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study. Turkish Journal of Medical Sciences. 2013; 43(6): 951 - 956.
Vancouver PANDIR D,KARA O Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study. Turkish Journal of Medical Sciences. 2013; 43(6): 951 - 956.
IEEE PANDIR D,KARA O "Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study." Turkish Journal of Medical Sciences, 43, ss.951 - 956, 2013.
ISNAD PANDIR, DİLEK - KARA, OZLEM. "Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study". Turkish Journal of Medical Sciences 43/6 (2013), 951-956.
Sayfa Oluşturulma Tarihi
23-04-2024 0:26

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