Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels

bakirtas, mustafa; ÖZLEM, Nuraydın; yildirim, kadir; ELBÜKEN, Gülşah; ÖZBALCI, Aysu Başak; KİRTİLOGLU, Banu; aktimur, recep; DEMİRAĞ, Mehmet Derya; AKTİMUR, Sude Hatun

Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels

Gülşah ELBÜKEN, (Department of Endocrinology and Metabolism, Samsun Training and Research Hospital, Samsun, Turkey)

Recep AKTİMUR, (Department of General Surgery, Samsun Training and Research Hospital, Samsun, Turkey)

Kadir YILDIRIM, (Department of General Surgery, Samsun Training and Research Hospital, Samsun, Turkey)

Sude Hatun AKTİMUR, (Department of Internal Medicine, Samsun Training and Research Hospital, Samsun, Turkey)

Mehmet Derya DEMİRAĞ, (Department of Internal Medicine, Samsun Training and Research Hospital, Samsun, Turkey)

Aysu Başak ÖZBALCI, (Department of Radiology, Samsun Training and Research Hospital, Samsun, Turkey)

Mustafa BAKIRTAŞ, (Department of Pathology, Samsun Training and Research Hospital, Samsun, Turkey)

Banu KİRTİLOGLU, (Department of Nuclear Medicine, Samsun Training and Research Hospital, Samsun, Turkey)

Nuraydın ÖZLEM (Department of General Surgery, Samsun Training and Research Hospital, Samsun, Turkey)

Medicine Science

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Yıl: 2015 Cilt: 4 Sayı: 3 Sayfa Aralığı: 2401 - 2413 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels

Öz:

The aim of the present study was to determine the relationship between biochemical parameters, mean diameter of parathyroid adenoma (MDPA) and parathyroid hormone (PTH) levels in patients who underwent parathyroid surgery.Materials and Methods: Data were collected retrospectively from patients with hyperparathyroidism who were operated and followed in our hospital between September 2011 and April 2014. Twenty-nine (male/female = 8/21) patients with a mean age of 58.31 ± 12.59 years were enrolled into the study. The mean pre-operative serum calcium and intact PTH (iPTH) levels were 11.98±1.23 mg/dl and 386.52±374.96 pg/ml, respectively. Serum pre-operative calcium levels were found to be significantly higher in patients who had nephrolithiasis than those who did not, whereas pre-operative serum phosphate levels were lower. Pre-operative iPTH levels were found to be correlated with pre-operative calcium, alkaline phosphatase and MDPA but not with preoperative serum phosphate. Also, pre-operative calcium levels were found to be significantly correlated with MDPA.Conclusion: Presence of nephrolithiasis is associated with higher preoperative calcium and lower phosphate levels. Pre-operative iPTH and calcium levels were also found to be significantly correlated with MDPA; this suggests that serum iPTH and calcium levels can be useful in predicting MDPA

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Fraser WD. Hyperparathyroidism. Lancet. 2009; 374(9684):145-58.
2. Felder EA, Kandil E. Primary hyperparathyroidism. Otolaryn Clin of North Am. 2010;43(2):417-32.
3. Marx SJ. Hyperparathyroid and hypoparathyroid disorders. N Engl J Med. 2000;343(25);1863-75.
4. Shane E. Clinical review 122: parathyroid carcinoma. J Clin Endocr Metab. 2001;86(2):485-93.
5. Bandeira F, Griz L, Chaves N, Carvalho NC, Borges LM, Lazaretti-Castro M, Borba V, de Castro LC, Borges JL, Bilezikian J. Diagnosis and management of primary hyperparathyroidism--a scientific statement from the Department of Bone Metabolism, the Brazilian Society for Endocrinology and Metabolism. Arq Bras Endocrinol Metabol. 2013;57(6):406-24.
6. Gordon W. The consequences of uncontrolled secondary hyperparathyroidism and its treatment in chronic kidney disease. Semin Dial. 2004;17(3):209-16.
7. Bilezikian JP, Khan A, Potts Jr JT. Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Third International Workshop. J Clin Endocrinol Metab. 2009;94(2):335-9.
8. Bilezikian JP, Brandi ML, Eastell R, Silverberg SJ, Udelsman R, Marcocci C, Potts JT Jr. Guidelines for the Management of Asymptomatic Primary Hyperparathyroidism: Summary Statement from the Fourth International Workshop. J Clin Endocrinol Metab. 2014;99(10):3561-9.
9. Silverberg SJ, Bilezikian JP. Primary hyperparathyroidism. In: Jameson JL, DeGroot LJ, senior eds, Endocrinology: Adult and Pediatric. 6th edition (online version). Philadelphia: Saunders; 2010.
10. Schlosser K, Endres N, Celik I, Fendrich V, Rothmund M, Fernández ED. Surgical treatment of tertiary hyperparathyroidism: the choice of procedure matters! World J Surg. 2007;31(10):1947-53.
11. Triponez F, Clark OH, Vanrenthergem Y, Evenepoel P. Surgical treatment of persistent hyperparathyroidism after renal transplantation. Ann Surg. 2008; 248(1):18- 30.
12. The American Association of Clinical Endocrinologists and the American Association of Endocrine Surgeons. Position statement on the diagnosis and management of primary hyperparathyroidism. Endocrine Practice. 2005;11(1):49-54.
13. Marcocci C, Bollerslev J, Khan AA, Shoback DM. Medical management of primary hyperparathyroidism: Proceedings of the Fourth International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism. J Clin Endocrinol Metab. 2014;99(10):3607-18.
14. Bollerslev J, Marcocci C, Sosa M, Nordenström J, Bouillon R, Mosekilde L. Current evidence for recommendation of surgery, medical treatment and vitamin D repletion in mild primary hyperparathyroidism. Eur J Endocrinol. 2011;165(6):851-64.
15. Moretz WH 3rd, Watts TL, Virgin FW Jr, Chin E, Gourin CG, Terris DJ. Correlation of intraoperative parathyroid hormone levels with parathyroid gland size. Laryngoscope. 2007;117(11):1957-60.
16. Kiyici S, Cander S, Oz Gul O, Sigirli D, Kaan Unal O, Duran C, Saraydaroglu O, Ersoy C, Tuncel E, Erturk E, Imamoglu S. Preoperative parathyroid hormone levels are correlated with parathyroid adenoma volume and bone mineral density but not serum calcium levels. Minerva Endocrinol. 2011;36(2):123-8.
17. Bindlish V, Freeman JL, Witterick IJ, Asa SL. Correlation of biochemical parameters with single parathyroid adenoma weight and volume. Head Neck. 2002;24(11):1000- 3.
18. Nasiri S, Sorush A, Hedayat A, Donboli K, Sodagari N, Mosafa S. Adenoma weight and biochemical parameters in primary hyperparathyroidism. Medical J of Islamic Repub of Iran. 2011;25(3):136-41.

APA	ELBÜKEN G, aktimur r, yildirim k, AKTİMUR S, DEMİRAĞ M, ÖZBALCI A, bakirtas m, KİRTİLOGLU B, ÖZLEM N (2015). Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels. , 2401 - 2413.
Chicago	ELBÜKEN Gülşah,aktimur recep,yildirim kadir,AKTİMUR Sude Hatun,DEMİRAĞ Mehmet Derya,ÖZBALCI Aysu Başak,bakirtas mustafa,KİRTİLOGLU Banu,ÖZLEM Nuraydın Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels. (2015): 2401 - 2413.
MLA	ELBÜKEN Gülşah,aktimur recep,yildirim kadir,AKTİMUR Sude Hatun,DEMİRAĞ Mehmet Derya,ÖZBALCI Aysu Başak,bakirtas mustafa,KİRTİLOGLU Banu,ÖZLEM Nuraydın Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels. , 2015, ss.2401 - 2413.
AMA	ELBÜKEN G,aktimur r,yildirim k,AKTİMUR S,DEMİRAĞ M,ÖZBALCI A,bakirtas m,KİRTİLOGLU B,ÖZLEM N Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels. . 2015; 2401 - 2413.
Vancouver	ELBÜKEN G,aktimur r,yildirim k,AKTİMUR S,DEMİRAĞ M,ÖZBALCI A,bakirtas m,KİRTİLOGLU B,ÖZLEM N Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels. . 2015; 2401 - 2413.
IEEE	ELBÜKEN G,aktimur r,yildirim k,AKTİMUR S,DEMİRAĞ M,ÖZBALCI A,bakirtas m,KİRTİLOGLU B,ÖZLEM N "Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels." , ss.2401 - 2413, 2015.
ISNAD	ELBÜKEN, Gülşah vd. "Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels". (2015), 2401-2413.

APA	ELBÜKEN G, aktimur r, yildirim k, AKTİMUR S, DEMİRAĞ M, ÖZBALCI A, bakirtas m, KİRTİLOGLU B, ÖZLEM N (2015). Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels. Medicine Science, 4(3), 2401 - 2413.
Chicago	ELBÜKEN Gülşah,aktimur recep,yildirim kadir,AKTİMUR Sude Hatun,DEMİRAĞ Mehmet Derya,ÖZBALCI Aysu Başak,bakirtas mustafa,KİRTİLOGLU Banu,ÖZLEM Nuraydın Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels. Medicine Science 4, no.3 (2015): 2401 - 2413.
MLA	ELBÜKEN Gülşah,aktimur recep,yildirim kadir,AKTİMUR Sude Hatun,DEMİRAĞ Mehmet Derya,ÖZBALCI Aysu Başak,bakirtas mustafa,KİRTİLOGLU Banu,ÖZLEM Nuraydın Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels. Medicine Science, vol.4, no.3, 2015, ss.2401 - 2413.
AMA	ELBÜKEN G,aktimur r,yildirim k,AKTİMUR S,DEMİRAĞ M,ÖZBALCI A,bakirtas m,KİRTİLOGLU B,ÖZLEM N Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels. Medicine Science. 2015; 4(3): 2401 - 2413.
Vancouver	ELBÜKEN G,aktimur r,yildirim k,AKTİMUR S,DEMİRAĞ M,ÖZBALCI A,bakirtas m,KİRTİLOGLU B,ÖZLEM N Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels. Medicine Science. 2015; 4(3): 2401 - 2413.
IEEE	ELBÜKEN G,aktimur r,yildirim k,AKTİMUR S,DEMİRAĞ M,ÖZBALCI A,bakirtas m,KİRTİLOGLU B,ÖZLEM N "Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels." Medicine Science, 4, ss.2401 - 2413, 2015.
ISNAD	ELBÜKEN, Gülşah vd. "Pre-opereative Parathormone Levels are Correlated with Mean Diameter of Parathyroid Adenoma and Pre-operatıve Serum Calcium and Alkaline Phosphatase Levels". Medicine Science 4/3 (2015), 2401-2413.