Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury

RAĞBETLİ, Murat Çetin; GULSEN, İsmail; AK, Hakan; SÖSUNCU, Enver; alp, hamit hakan; ATALAY, Tugay; ÇÖLÇİMEN, Neşe; ALACA, İlker

Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury

Tugay ATALAY, (Bozok University, School of Medicine, Department of Neurosurgery, Yozgat, Turkey)

İsmail GULSEN, (Yuzuncu Yıl University, Department of Neurosurgery, Van, Turkey)

Neşe ÇÖLÇİMEN, (Yuzuncu Yıl University, Department of Histology and Embryology, Van, Turkey)

Hamit Hakan ALP, (Yuzuncu Yıl University, Department of Biochemistry, Van, Turkey)

Enver SÖSUNCU, (Ercis State Hospital, Department of Neurosurgery, Van, Turkey)

İlker ALACA, (Yuksekova State Hospital, Department of Neurosurgery, Hakkari, Turkey)

Hakan AK, (Bozok University, School of Medicine, Department of Neurosurgery, Yozgat, Turkey)

Murat Çetin RAĞBETLİ (Yuzuncu Yıl University, Department of Histology and Embryology, Van, Turkey)

Turkish Neurosurgery

2 0

Yıl: 2017 Cilt: 27 Sayı: 6 Sayfa Aralığı: 924 - 930 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury

Öz:

AIm: Traumatic brain injury (TBI) is a complex process. Increasing evidence has demonstrated that reactive oxygen species contribute to brain injury. Resveratrol (RVT) which exhibits significant antioxidant properties, is neuroprotective against excitotoxicity, ischemia, and hypoxia. The aim of this study was to evaluate the neuroprotective effects of RVT on the hippocampus of a rat model of TBI. mATERIAl and mEThODS: Twenty eight rats were divided into four groups. A moderate degree of head trauma was induced using Feeney’s falling weight technique. Group 1 (control) underwent no intervention or treatment. Head trauma was induced in Group 2 (trauma) and no drug was administered. Head trauma was induced in Group 3 and low-dose RVT (50 mg/kg per day) was injected. In Group 4, high-dose RVT (100 mg/kg per day) was used after head trauma. Brain tissues were extracted immediately after perfusion without damaging the tissues. Histopathological and biochemistry parameters were studied. RESUlTS: Brain tissue malondialdehyde (MDA) levels in the trauma group were significantly higher than those in the control, lowdose RVT-treated, and high-dose-RVT-treated groups. The superoxide dismutase (SOD) levels in the control group were significantly higher than those in the trauma, low-dose RVT-treated, and high-dose RVT-treated groups. Glutathione peroxidase (GSH-Px) levels in the control group were significantly higher than those in the trauma and low-dose RVT-treated groups. The level of oxidative deoxyribonucleic acid (DNA) damage (8-OHdG/106 dG) in the trauma group was higher than that in the control group, low-dose RVT-treated, and high-dose RVT-treated groups. CONClUSION: Resveratrol has a healing effect on neurons after TBI

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Konular: Cerrahi

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APA	ATALAY T, GULSEN İ, ÇÖLÇİMEN N, alp h, SÖSUNCU E, ALACA İ, AK H, RAĞBETLİ M (2017). Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury. , 924 - 930.
Chicago	ATALAY Tugay,GULSEN İsmail,ÇÖLÇİMEN Neşe,alp hamit hakan,SÖSUNCU Enver,ALACA İlker,AK Hakan,RAĞBETLİ Murat Çetin Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury. (2017): 924 - 930.
MLA	ATALAY Tugay,GULSEN İsmail,ÇÖLÇİMEN Neşe,alp hamit hakan,SÖSUNCU Enver,ALACA İlker,AK Hakan,RAĞBETLİ Murat Çetin Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury. , 2017, ss.924 - 930.
AMA	ATALAY T,GULSEN İ,ÇÖLÇİMEN N,alp h,SÖSUNCU E,ALACA İ,AK H,RAĞBETLİ M Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury. . 2017; 924 - 930.
Vancouver	ATALAY T,GULSEN İ,ÇÖLÇİMEN N,alp h,SÖSUNCU E,ALACA İ,AK H,RAĞBETLİ M Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury. . 2017; 924 - 930.
IEEE	ATALAY T,GULSEN İ,ÇÖLÇİMEN N,alp h,SÖSUNCU E,ALACA İ,AK H,RAĞBETLİ M "Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury." , ss.924 - 930, 2017.
ISNAD	ATALAY, Tugay vd. "Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury". (2017), 924-930.

APA	ATALAY T, GULSEN İ, ÇÖLÇİMEN N, alp h, SÖSUNCU E, ALACA İ, AK H, RAĞBETLİ M (2017). Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury. Turkish Neurosurgery, 27(6), 924 - 930.
Chicago	ATALAY Tugay,GULSEN İsmail,ÇÖLÇİMEN Neşe,alp hamit hakan,SÖSUNCU Enver,ALACA İlker,AK Hakan,RAĞBETLİ Murat Çetin Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury. Turkish Neurosurgery 27, no.6 (2017): 924 - 930.
MLA	ATALAY Tugay,GULSEN İsmail,ÇÖLÇİMEN Neşe,alp hamit hakan,SÖSUNCU Enver,ALACA İlker,AK Hakan,RAĞBETLİ Murat Çetin Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury. Turkish Neurosurgery, vol.27, no.6, 2017, ss.924 - 930.
AMA	ATALAY T,GULSEN İ,ÇÖLÇİMEN N,alp h,SÖSUNCU E,ALACA İ,AK H,RAĞBETLİ M Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury. Turkish Neurosurgery. 2017; 27(6): 924 - 930.
Vancouver	ATALAY T,GULSEN İ,ÇÖLÇİMEN N,alp h,SÖSUNCU E,ALACA İ,AK H,RAĞBETLİ M Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury. Turkish Neurosurgery. 2017; 27(6): 924 - 930.
IEEE	ATALAY T,GULSEN İ,ÇÖLÇİMEN N,alp h,SÖSUNCU E,ALACA İ,AK H,RAĞBETLİ M "Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury." Turkish Neurosurgery, 27, ss.924 - 930, 2017.
ISNAD	ATALAY, Tugay vd. "Resveratrol Treatment Prevents Hippocampal Neurodegeneration in a Rodent Model of Traumatic Brain Injury". Turkish Neurosurgery 27/6 (2017), 924-930.