Objective: Data obtained from cases wherein methyl methacrylate was used for cranioplasty are discussed along with the literature,and methods for preventing potential complications are presented.Methods: Records of patients who had been operated for cranioplasty between 2013 and 2017 were retrospectively analyzed.Early and late results of the cases were recorded. Area measurements of cranium defects were performed through computed tomography,scanography, or direct X-ray. The steps considered for preventing known complications are explained, and the resultsare discussed.Results: Cranioplasty with methyl methacrylate was administered to areas <10 cm2 in 29 cases, areas of 10–25 cm2 in 25 cases,and areas >25 cm2 in 10 cases. Cranioplasty with methyl methacrylate was performed in the supratentorial area in 57 cases and inthe infratentorial area in 7 cases. In 48 cases, partial cranioplasty was performed by administering methyl methacrylate along withautograft to the craniectomy defect. A subcutaneous drain was left for 2–3 days in all cases. During this period, dual antibiotherapywas administered. Symptoms of infection were not encountered in any case. No clinical symptoms associated with cranioplastymaterial were discovered in the late follow-up period.Conclusion: When methyl methacrylate is applied with appropriate methods and necessary precautions are taken, it proves asan inexpensive and effective cranioplasty material that can successfully be applied in large cranial defects, which reduces therisk of infection. This inexpensive material can be applied to repair partial craniotomy flap deformities to achieve better cosmeticoutcomes.