Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?
Yıl: 2019 Cilt: 28 Sayı: 1 Sayfa Aralığı: 23 - 28 Metin Dili: İngilizce DOI: 10.5336/ophthal.2018-60159 İndeks Tarihi: 12-05-2020
Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?
Öz: Objective: In this study, it is aimed to investigate the dynamic thiol-disulfide homeostasis which is an indicator of oxidative stress in retinal vein occlusion patients. Material andMethods: Thirty nine retinal vein occlusion patients and 38 age-gender matched control subjectswere included in the study. Exclusion criteria for retinal vein occlusion group were: ocular historyand symptoms exceeding 3 weeks, any other history of ocular disease except the retinal vein occlusion, any previous ocular surgeries or lasers, any previous treatment or intra-vitreal injectionfor the retinal vein occlusion, any other systemic disease except the arterial hypertension. The control group included patients without any ocular or systemic diseases. Native thiol, total thiol, disulfide levels were studied in the serum samples of all participants and native/total thiol anddisulfide/total thiol ratios were calculated as percentage. Results: Total thiol, native thiol, disulfide, native/total thiol and disulfide/total thiol ratio were not significantly different betweenthe retinal vein occlusion and the control groups. In the control group, age was inversely correlated with the total thiol level, but not with the other serum parameters. In the retinal veinocclusion group, there was no correlation among the age and the serum parameters but the bodymass index (BMI) was inversely correlated with the total thiol level. Conclusion: There was notany significant difference between the retinal vein occlusion patients and the control subjects forthe thiol-disulfide homeostasis.
Anahtar Kelime: Konular:
Retinal Ven Tıkanıklığı ve Bir Oksidatif Stres Belirteci Olan Tiyol-Disülfit Dengesi Arasında Herhangi Bir İlişki Var mıdır?
Öz: Amaç: Bu çalışmada retinal ven tıkanıklığı ile bir oksidatif stres belirteci olan dinamik tiyol-disülfit dengesi arasındaki ilişkinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Otuz dokuz retinal ven tıkanıklığı hastası ve 38 yaş ve cinsiyet eşleştirilmiş kontrol birey olmak üzere toplam 77 katılımcı çalışmaya alınmıştır. Retinal ven tıkanıklığı grubu için çalışmadan dışlanma kriterleri: 3 haftayı aşan göz şikayet ve bulguları, retinal ven tıkanıklığı dışında başka oküler hastalık öyküsünün olması, daha önce oküler cerrahi ve lazer öyküsünün olması, retinal ven tıkanıklığı için daha önce intravitreal enjeksiyon dahil olmak üzere herhangi bir tedavi uygulanmış olması, arteryel hipertansiyon dışında sistemik hastalık öyküsünün olması olarak belirlenmiştir. Kontrol grubu sistemik ve oküler hastalığı olmayan katılımcılardı. Native tiyol, total thiol, disülfit düzeyleri katılımcıların kan serumu örneklerinde çalışılarak belirlenmiştir ve native/total tiyol ve disülfit/total tiyol oranları hesaplanarak yüzde olarak kaydedilmiştir. Bulgular: Total tiyol, native tiyol, disülfit, native/total tiyol oranı ve disülfit/total tiyol oranları retinal ven tıkanıklığı ve kontrol grubu arasında karşılaştırıldığında anlamlı fark bulunmamıştır. Kontrol grubunda yaş ve total tiyol seviyeleri arasında negatif korelasyon olduğu, fakat diğer parametreler arasında anlamlı ilişki olmadığı bulunmuştur. Retinal ven tıkanıklığı grubunda yaş ve serum parametreleri arasında anlamlı ilişki bulunmamış, fakat beden kitle indeksi (BKİ) ile total tiyol düzeyleri arasında negatif korelasyon bulunmuştur. Sonuç: Retinal ven tıkanıklığı ve kontrol grupları arasında tiyol-disülfit dengesi açısından anlamlı fark bulunmamıştır.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | POLAT O, Kurt A, KILIÇ R, nar r, kocamis o (2019). Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?. , 23 - 28. 10.5336/ophthal.2018-60159 |
| Chicago | POLAT Osman Ahmet,Kurt Ali,KILIÇ Raşit,nar rukiye,kocamis ozkan Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?. (2019): 23 - 28. 10.5336/ophthal.2018-60159 |
| MLA | POLAT Osman Ahmet,Kurt Ali,KILIÇ Raşit,nar rukiye,kocamis ozkan Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?. , 2019, ss.23 - 28. 10.5336/ophthal.2018-60159 |
| AMA | POLAT O,Kurt A,KILIÇ R,nar r,kocamis o Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?. . 2019; 23 - 28. 10.5336/ophthal.2018-60159 |
| Vancouver | POLAT O,Kurt A,KILIÇ R,nar r,kocamis o Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?. . 2019; 23 - 28. 10.5336/ophthal.2018-60159 |
| IEEE | POLAT O,Kurt A,KILIÇ R,nar r,kocamis o "Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?." , ss.23 - 28, 2019. 10.5336/ophthal.2018-60159 |
| ISNAD | POLAT, Osman Ahmet vd. "Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?". (2019), 23-28. https://doi.org/10.5336/ophthal.2018-60159 |
| APA | POLAT O, Kurt A, KILIÇ R, nar r, kocamis o (2019). Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?. Türkiye Klinikleri Oftalmoloji Dergisi, 28(1), 23 - 28. 10.5336/ophthal.2018-60159 |
| Chicago | POLAT Osman Ahmet,Kurt Ali,KILIÇ Raşit,nar rukiye,kocamis ozkan Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?. Türkiye Klinikleri Oftalmoloji Dergisi 28, no.1 (2019): 23 - 28. 10.5336/ophthal.2018-60159 |
| MLA | POLAT Osman Ahmet,Kurt Ali,KILIÇ Raşit,nar rukiye,kocamis ozkan Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?. Türkiye Klinikleri Oftalmoloji Dergisi, vol.28, no.1, 2019, ss.23 - 28. 10.5336/ophthal.2018-60159 |
| AMA | POLAT O,Kurt A,KILIÇ R,nar r,kocamis o Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?. Türkiye Klinikleri Oftalmoloji Dergisi. 2019; 28(1): 23 - 28. 10.5336/ophthal.2018-60159 |
| Vancouver | POLAT O,Kurt A,KILIÇ R,nar r,kocamis o Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?. Türkiye Klinikleri Oftalmoloji Dergisi. 2019; 28(1): 23 - 28. 10.5336/ophthal.2018-60159 |
| IEEE | POLAT O,Kurt A,KILIÇ R,nar r,kocamis o "Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?." Türkiye Klinikleri Oftalmoloji Dergisi, 28, ss.23 - 28, 2019. 10.5336/ophthal.2018-60159 |
| ISNAD | POLAT, Osman Ahmet vd. "Is There Any Association Between the Retinal Vein Occlusion and the Thiol-Disulfide Homeostasis Which is an Oxidative Stress Indicator?". Türkiye Klinikleri Oftalmoloji Dergisi 28/1 (2019), 23-28. https://doi.org/10.5336/ophthal.2018-60159 |
