Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis

Özkan KOCAMIŞ, (Ahi Evran Üniversitesi, Tıp Fakültesi, Göz ABD, Kırşehir, Türkiye)
Burç Esra ŞAHİN (Ahi Evran Üniversitesi, Tıp Fakültesi, Nöroloji ABD, Kırşehir, Türkiye)
Retina-Vitreus
1 0
Yıl: 2019 Cilt: 28 Sayı: 3 Sayfa Aralığı: 296 - 301 Metin Dili: İngilizce İndeks Tarihi: 06-10-2020

Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis

Öz:
Purpose: We aimed to measure lamina cribrosa thickness (LCT), lamina cribrosa depth (LCD) and retinal nerve fiber layer (RNFL) thickness in multiple sclerosis (MS) patients and compare the results with eyes of healthy subjects.Materials and Methods: The eyes of multiple sclerosis patients were compared with the eyes of a healthy control group. A full ophthalmologic examination was conducted for both groups. Optic coherence tomography (OCT) was used to measure LCT, LCD, and RNFL thickness values. Correlation analysis was conducted between the Expanded Disability Status Scale (EDSS) score and disease duration of the MS patients and the LCT, LCD, and RNFL thicknesses.Results: Mean LCT values were 171.86±62.81 μm in the MS group and 230.1±66.84 μm in the control group. LCT was statistically significantly lower in the MS group than the control group (p<0.001). Mean LCD value was 300.9±100.5 μm in the MS group and 279.68±99.78 μm in the control group with no statistically signifi cant difference (p˃0.05). Mean RNFL thickness was 96 μm in MS group and 100 μm in the control group and was statistically signifi cantly lower in the MS group (p<0.05). A statistically signifi cantly moderate relationship was found between disease duration and EDSS score in the MS group with Spearman correlation analysis (r=0.468, p<0.01). A statistically signifi cantly moderate relationship was found between the RNFL thickness and both disease duration and EDSS score (r=-0.574, r=-0.601, respectively, p<0.001).Conclusion: The intraocular nerve fi ber layer was affected in multiple sclerosis patients. The LCT and RNFL thickness were thinner in MS patients than in the control group but there was no difference in terms of LCD values.
Anahtar Kelime:

Multiple Sklerozda Lamina Kribroza Tabakasının Araştırılması

Öz:
Amaç: Multipl skleroz (MS) hastalarında lamina cribrosa kalınlığı (LKK), lamina cribrosa derinliği (LKD) ve retina sinir lifi tabakası (RSLT) kalınlığını ölçmeyi ve sağlıklı gözlerin sonuçları ile karşılaştırmayı amaçladık. Gereç ve Yöntemler: Multipl skleroz hastalarının gözleri sağlıklı kontrol grubunun gözleri ile karşılaştırıldı. Her iki grup için tam oftalmolojik muayene yapıldı. LKK, LKD ve RSLT kalınlık değerlerini ölçmek için optik koherens tomografi (OKT) kullanıldı. MS hastalarının Genişletilmiş Engellilik Durum Ölçeği (GEDÖ) skoru ve hastalık süresi ile LKK, LKD ve RSLT kalınlıkları arasında korelasyon analizi yapıldı. Bulgular: Ortalama LKK değerleri MS grubunda 171.86 ± 62.81 μm, kontrol grubunda 230.1 ± 66.84 μm idi. LKK MS grubunda kontrol grubundan istatistiksel olarak anlamlı derecede düşüktü (p <0.001). Ortalama LKD değeri MS grubunda 300.9 ± 100.5 μm, kontrol grubunda 279.68 ± 99.78 μm idi ve istatistiksel olarak anlamlı bir fark yoktu (p˃0.05). Ortalama RSLT kalınlığı MS grubunda 96 μm, kontrol grubunda 100 μm idi ve MS grubunda istatistiksel olarak anlamlı derecede düşüktü (p <0.05). Spearman korelasyon analizi ile MS grubunda hastalık süresi ile GEDÖ skoru arasında istatistiksel olarak anlamlı bir ilişki bulundu (r = 0.468, p <0.01). RSLT kalınlığı ile hem hastalık süresi hem de GEDÖ skoru arasında istatistiksel olarak anlamlı bir ilişki bulundu (r = -0.574, r = -0.601, sırasıyla, p <0.001). Sonuç: Göz içi sinir lifi tabakası multiple skleroz hastalarında etkilenmiştir. LKK ve RSLT kalınlığı MS hastalarında kontrol grubundan daha ince idi, ancak LKD değerleri açısından fark yoktu.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik
  • Ikuta F, Zimmerman HM. Distribution of plaques in seventy autopsy cases of multiple sclerosis in the United States. Neurology 1976;26:26–8.
  • Toussaint D, Périer O, Verstappen A et al. Clinicopathological study of the visual pathways, eyes, and cerebral hemispheres in 32 cases of disseminated sclerosis. J Clin Neuroophthalmol 1983;3:211–20.
  • Compston A, Coles A. Multiple sclerosis. Lancet 2008;372: 1502–1517.
  • Jonas JB, Mardin CY, Schlo¨ tzer-Schrehardt U et al. Morphometry of the human lamina cribrosa surface. Invest Ophthalmol Vis Sci 1991;32:401–405.
  • Downs JC, Roberts MD, Burgoyne CF. Mechanical environment of the optic nerve head in glaucoma. Optom Vis Sci 2008;85:425–435.
  • Jonas JB, Berenshtein E, Holbach L. Anatomic relationship between lamina cribosa, intraocular space, and cerebrospinal fl uid space. Invest Ophthalmol Vis Sci 2003;44:5189–5195.
  • Hernandez MR, Ye H. Glaucoma: changes in extracellular matrix in the optic nerve head. Ann Med 1993;25: 309–315.
  • Bellezza AJ, Rintalan CJ, Thompson HW et al. Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma. Invest Ophthalmol Vis Sci 2003;44: 623–637.
  • Crawford Downs J, Roberts MD et al. Glaucomatous cupping of the lamina cribrosa: a review of the evidence for active progressive remodeling as a mechanism. Exp Eye Res 2011;93:133–140.
  • Yan DB, Coloma FM, Metheetrairut A, Trope GE, Heathcote JG, Ethier CR. Deformation of the lamina cribrosa by elevated intraocular pressure. Br J Ophthalmol 1994;78:643–648.
  • Pulicken M, Gordon-Lipkin E, Balcer LJ et al. Optical coherence tomography and disease subtype in multiple sclerosis. Neurology 2007; 69:2085–92.
  • Petzold A, Balcer LJ, Calabresi PA et al. Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis. Lancet Neurol 2017;1610:797–812.
  • Saidha S, Al-Louzi O, Ratchford JN et al. Optical coherence tomography refl ects brain atrophy in multiple sclerosis: a fouryear study. Ann Neurol 2015;78:801–13.
  • Crawford Downs J, Roberts MD, Sigal IA. Glaucomatous cupping of the lamina cribrosa: a review of the evidence for active progressive remodeling as a mechanism. Exp Eye Res 2011;93:133–140.
  • Yan DB, Coloma FM, Metheetrairut A et al. Deformation of the lamina cribrosa by elevated intraocular pressure. Br J Ophthalmol 1994;78:643–648.
  • Britze J, Pihl-Jensen G, Frederiksen JL. Retinal ganglion cell analysis in multiple sclerosis and optic neuritis: a systematic review and meta-analysis. J Neurol 2017;264:1837–1853.
  • Merle H, Olindo S, Donnio A et al. Retinal peripapillary nerve fi ber layer thickness in neuromyelitis optica. Invest Ophthalmol Vis Sci 2008;49:4412–7.
  • Albrecht P, Frohlich R, Hartung HP et al. Optical coherence tomography measures axonal loss in multiple sclerosis independently of optic neuritis. J Neurol 2007;254:1595–6.
  • Fisher JB, Jacobs DA, Markowitz CE et al. Relation of visual function to retinal nerve fi ber layer thickness in multiple sclerosis. Ophthalmology 2006;113:324–32.
  • Kucharczuk J, Maciejek Z, Sikorski BL. Optical coherence tomography in diagnosis and monitoring multiple sclerosis. Neurol Neurochir Pol. 2018;52(2):140-149
  • Davies EC, Galetta KM, Sackel DJ et al. Retinal ganglion cell layer volumetric assessment by spectral-domain optical coherence tomography in multiple sclerosis: Application of a high-precision manual estimation technique. J Neuroophthalmol 2011;31:260-4.
  • Cennamo G, Romano MR, Vecchio EC et al. Anatomical and functional retinal changes in multiple sclerosis. Eye (Lond) 2016;30:456-62.
  • Tátrai E, Simó M, Iljicsov A et al. In vivo evaluation of retinal neurodegeneration in patients with multiple sclerosis. PLoS One 2012;7:e30922.
  • Pillay G, Ganger A, Singh D et al. Retinal nerve fi ber layer and ganglion cell layer changes on optical coherence tomography in early multiple sclerosis and optic neuritis cases Indian J Ophthalmol. 2018;66:114-119.
  • Jonas JB, Berenshtein E, Holbach L. Lamina cribrosa thickness and spatial relationships between intraocular space and cerebrospinal fl uid space in highly myopic eyes. Invest Ophthalmol Vis Sci 2004;45: 2660-2665.
  • Park HY, Jeon SH, Park CK. Enhanced depth imaging detects lamina cribrosa thickness differences in normal tension glaucoma and primary open-angle glaucoma. Ophthalmology 2012;119:10-20.
  • Reis AS, O'Leary N, Stanfi eld MJ et al. Laminar displacement and prelaminar tissue thickness change after glaucoma surgery imaged with optical coherence tomography. Invest Ophthalmol Vis Sci 2012;53:5819-5826.
  • Barrancos C, Rebolleda G, Oblanca N et al. Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy. Eye (Lond) 2014;28:58-65.
  • Siepman TA, Bettink-Remeijer MW, Hintzen RQ. Retinal nerve fi ber layer thickness in subgroups of multiple sclerosis, measured by optical coherence tomography and scanning laser polarimetry.J Neurol 2010;257:1654–1660.
  • Toledo J, Sepulcre J, Salinas-Alaman A et al. Retinal nerve fi ber layer atrophy is associated with physical and cognitive disability in multiple sclerosis. Mult Scler 2008;14:906–912.
  • Oreja-Guevara C, Noval S, Manzano B et al. Optic neuritis, multiple sclerosis-related or not: structural and functional study Neurologia 2010;25:78–82.
  • Bsteh G, Hegen H, Teuchner B et al. Peripapillary retinal nerve fi bre layer as measured by optical coherence tomography is a prognostic biomarker not only for physical but also for cognitive disability progression in multiple sclerosis. Mult Scler.2019;25:196-203.
APA kocamis o, Şahin B (2019). Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis. , 296 - 301.
Chicago kocamis ozkan,Şahin Burç Esra Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis. (2019): 296 - 301.
MLA kocamis ozkan,Şahin Burç Esra Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis. , 2019, ss.296 - 301.
AMA kocamis o,Şahin B Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis. . 2019; 296 - 301.
Vancouver kocamis o,Şahin B Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis. . 2019; 296 - 301.
IEEE kocamis o,Şahin B "Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis." , ss.296 - 301, 2019.
ISNAD kocamis, ozkan - Şahin, Burç Esra. "Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis". (2019), 296-301.
APA kocamis o, Şahin B (2019). Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis. Retina-Vitreus, 28(3), 296 - 301.
Chicago kocamis ozkan,Şahin Burç Esra Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis. Retina-Vitreus 28, no.3 (2019): 296 - 301.
MLA kocamis ozkan,Şahin Burç Esra Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis. Retina-Vitreus, vol.28, no.3, 2019, ss.296 - 301.
AMA kocamis o,Şahin B Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis. Retina-Vitreus. 2019; 28(3): 296 - 301.
Vancouver kocamis o,Şahin B Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis. Retina-Vitreus. 2019; 28(3): 296 - 301.
IEEE kocamis o,Şahin B "Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis." Retina-Vitreus, 28, ss.296 - 301, 2019.
ISNAD kocamis, ozkan - Şahin, Burç Esra. "Evaluation of Lamina Cribrosa Layer in Multiple Sclerosis". Retina-Vitreus 28/3 (2019), 296-301.
Sayfa Oluşturulma Tarihi
23-04-2024 13:36

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