Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing
Yıl: 2020 Cilt: 9 Sayı: 1 Sayfa Aralığı: 53 - 58 Metin Dili: İngilizce DOI: 10.31196/huvfd.704364 İndeks Tarihi: 20-11-2020
Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing
Öz: Momordica charantia and Propolis (MCP) are reported to have antibacterial, antifungal, antioxidant and antiinflammatory properties. The present study determines the efficacy of the oral and topical administration of MCP onwound healing in 60 adult male rats. The wounds in the control rats were left untreated, the rats in the MCP-oral groupwere treated with oral MCP, and the animals in the MCP-topical group were treated by pouring MCP powder onto thewound. The wound size was measured on the 3rd, 7th, 14th and 21st days, and tissue specimens were taken from fiveanimals in both groups. The tissue samples were evaluated histopathologically. Remission following treatment during thefollow-up period was described as a percentage of the original wound size for each rat. A two-way ANOVA was used for theanalysis of data. The mean wound surface area was measured as 1.69 cm2. At the end of the experiment, the averagereduction was 81.40 % in MCP-topically and 87.85% in MCP-orally treated wounds. The lowest decrease in wound size wasmeasured in the control group (45.55 %). Wound size reduction was not significantly different between the MCP groups atthe end of the experiment. Re-epithelialization and neovascularization were complete in both the MCP-oral and MCPtopical groups up to day 21. Overall, the treatments with oral and topical MCP were equally effective in wound healing.MCP application can be considered for the acceleration of wound healing, in both oral and topical administrations.
Anahtar Kelime: Momordica Charantia-Propolis Premiksinin Yara Iyileşmesinde Oral ve Topikal Etkileri
Öz: Momordica charantia ve Propolis'in (MCP) antibakteriyel, antifungal, antioksidan ve antienflamatuar özelliklere sahip olduğu bildirilmektedir. Bu çalışmada, 60 yetişkin erkek sıçanda MCP'nin oral ve topikal uygulanmasının yara iyileşmesi üzerindeki etkinliğinin belirlenmesi amaçlanmıştır. Çalışmada kontrol sıçanlarındaki yaralar tedavi edilmeden bırakıldı, MCPoral gruptaki sıçanlar oral MCP ile tedavi edildi ve MCP topikal grubundaki hayvanlar, yara üzerine MCP tozu dökülerek tedavi edildi. Yara boyutu 3., 7., 14. ve 21. günlerde ölçüldü ve her iki gruptaki beş hayvandan doku örnekleri alındı. Doku örnekleri histopatolojik olarak değerlendirildi. Takip süresi boyunca tedaviyi takiben remisyon, her sıçan için orijinal yara boyutunun yüzdesi olarak tanımlandı. Verilerin analizi için iki yönlü bir ANOVA kullanıldı. Ortalama yara yüzey alanı 1.69 cm2 olarak ölçüldü. Deneyin sonunda ortalama azalma MCP-topikal grubunda %81.40 ve MCP-oral grubundaki yaralarda%87.85 idi. Yara boyutundaki en düşük azalma kontrol grubunda (%45.55) ölçüldü. Yara boyutundaki küçülme, deney sonunda MCP grupları arasında önemli ölçüde farklı değildi. 21. güne kadar hem MCP-oral hem de MCP-topikal gruplarda yeniden epitelizasyon ve neovaskülarizasyon tamamlandı. Genel olarak, oral ve topikal MCP ile yapılan tedaviler yara iyileşmesinde eşit derecede etkilidir. Momordica charantia ve Propolis'in hem oral hem de topikal uygulamaları yara iyileşmesinin hızlandırılması için düşünülebilir
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Doğan E, Yenice G, Gedikli S, Okur S (2020). Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing. , 53 - 58. 10.31196/huvfd.704364 |
| Chicago | Doğan Elif,Yenice Güler,Gedikli Semin,Okur Sıtkıcan Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing. (2020): 53 - 58. 10.31196/huvfd.704364 |
| MLA | Doğan Elif,Yenice Güler,Gedikli Semin,Okur Sıtkıcan Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing. , 2020, ss.53 - 58. 10.31196/huvfd.704364 |
| AMA | Doğan E,Yenice G,Gedikli S,Okur S Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing. . 2020; 53 - 58. 10.31196/huvfd.704364 |
| Vancouver | Doğan E,Yenice G,Gedikli S,Okur S Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing. . 2020; 53 - 58. 10.31196/huvfd.704364 |
| IEEE | Doğan E,Yenice G,Gedikli S,Okur S "Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing." , ss.53 - 58, 2020. 10.31196/huvfd.704364 |
| ISNAD | Doğan, Elif vd. "Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing". (2020), 53-58. https://doi.org/10.31196/huvfd.704364 |
| APA | Doğan E, Yenice G, Gedikli S, Okur S (2020). Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing. Harran Üniversitesi Veteriner Fakültesi Dergisi, 9(1), 53 - 58. 10.31196/huvfd.704364 |
| Chicago | Doğan Elif,Yenice Güler,Gedikli Semin,Okur Sıtkıcan Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing. Harran Üniversitesi Veteriner Fakültesi Dergisi 9, no.1 (2020): 53 - 58. 10.31196/huvfd.704364 |
| MLA | Doğan Elif,Yenice Güler,Gedikli Semin,Okur Sıtkıcan Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing. Harran Üniversitesi Veteriner Fakültesi Dergisi, vol.9, no.1, 2020, ss.53 - 58. 10.31196/huvfd.704364 |
| AMA | Doğan E,Yenice G,Gedikli S,Okur S Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing. Harran Üniversitesi Veteriner Fakültesi Dergisi. 2020; 9(1): 53 - 58. 10.31196/huvfd.704364 |
| Vancouver | Doğan E,Yenice G,Gedikli S,Okur S Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing. Harran Üniversitesi Veteriner Fakültesi Dergisi. 2020; 9(1): 53 - 58. 10.31196/huvfd.704364 |
| IEEE | Doğan E,Yenice G,Gedikli S,Okur S "Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing." Harran Üniversitesi Veteriner Fakültesi Dergisi, 9, ss.53 - 58, 2020. 10.31196/huvfd.704364 |
| ISNAD | Doğan, Elif vd. "Effects of Oral and Topical Momordica Charantia-Propolis Premix on Wound Healing". Harran Üniversitesi Veteriner Fakültesi Dergisi 9/1 (2020), 53-58. https://doi.org/10.31196/huvfd.704364 |
