Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder

YILDIZ, Mesut; Yorguner, Nese; Batmaz, Sedat; Çelikbaş, Zekiye; Oran demir, Meral; ergün, serhat

doi:10.5455/PBS.20180626100402

Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder

Mesut YILDIZ, (Marmara Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, İstanbul, Türkiye)

Neşe YORGUNER KÜPELİ, (Marmara Üniversitesi, Pendik Eğitim ve Araştırma Hastanesi, Psikiyatri Kliniği, İstanbul, Türkiye)

Meral O. DEMİR, (Tokat Ruh Sağlığı ve Hastalıkları Hastanesi, Tokat, Türkiye)

Sedat BATMAZ, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Tokat, Türkiye)

Zekiye ÇELİKBAŞ, (Tokat Ruh Sağlığı ve Hastalıkları Hastanesi, Tokat, Türkiye)

Serhat ERGÜN (Marmara Üniversitesi, Pendik Eğitim ve Araştırma Hastanesi, Psikiyatri Kliniği, İstanbul, Türkiye)

Psychiatry and behavioral sciences (Online)

11 4

Yıl: 2018 Cilt: 8 Sayı: 2 Sayfa Aralığı: 71 - 78 Metin Dili: İngilizce DOI: 10.5455/PBS.20180626100402 İndeks Tarihi: 08-12-2020

Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder

Öz:

Objective: There is an association between bipolar disorder and autism spectrum disorders. The aim of the current study isto examine the autistic characteristics of bipolar patients and to determmine their relationship with the clinical features of thediseaseMethods: Using a cross-sectional design, 148 patients with bipolar disorder (BD) were recruited to the study. The patients’clinical status were assessed by using Montgomery-Asberg Depression Rating Scale and Young Mania Rating Scale. Autistic liketraits/symptoms were measured using the Autism-Spectrum Quotient (AQ).Results: Within the whole group 26.4 % of the participants were classified as demonstrating higher levels of autistic traits. Therewas a weak positive correlation between communication/mind reading subscale of the AQ, and depression and mania severity.No significant correlations were observed between the autistic traits, and other demographic and clinical variablesConclusions: We found a low rate of autistic traits/symptoms in patients with BD compared to other studies. There wereweak positive correlations between the autistic features and depression and mania severity. Identification of autistic features inbipolar patients may help to better understand the etiology and clinical manifestation of the disorder.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Merikangas KR, Akiskal HS, Angst J, Greenberg PE, Hirschfeld RM, Petukhova M, et al. Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry 2007;64(5):543-52. Erratum in: Arch Gen Psychiatry 2007;64:1039. [CrossRef]
2. Falkai P, Malchow B, Schmitt A. Neurobiological background of affective disorders. In: Dieter Schoepf, ed. Psychiatric Disorders-New Frontiers in Affective Disorders. Intech 2013, p. 3-20. [CrossRef]
3. Wing L. Language, social, and cognitive impairments in autism and severe mental retardation. J Autism Dev Disord 1981;11(1):31-44. [CrossRef]
4. Simonoff E, Pickles A, Charman T, Chandler S, Loucus T, baird G. Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. J Am Acad Child Adolesc Psychiatry 2008;47(8):921-9. [CrossRef]
5. Vannucchi G, Masi G, Toni C, Dell’Osso L, Erfurth A, Perugi G. Bipolar disorder in adults with Asperger’s Syndrome: a systematic review. J Affect Disord 2014;168:151-60. [CrossRef]
6. Piven J, Palmer P. Psychiatric disorder and the broad autism phenotype: evidence from a family study of multiple-incidence autism families. Am J Psychiatry 1999;156(4):557-63.
7. Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 2013;381(9875):1371-9. [CrossRef]
8. Buoli M, Caldiroli A, Caletti E, Zugno E, Altamura AC. The impact of mood episodes and duration of illness on cognition in bipolar disorder. Compr Psychiatry 2014;55(7):1561-6. [CrossRef]
9. Bora E, Bartholomeusz C, Pantelis C. Meta-analysis of Theory of Mind (ToM) impairment in bipolar disorder. Psychol Med 2016;46(2):253-64. [CrossRef]
10. Pine DS, Guyer AE, Goldwin M, Towbin KA, Leibenluft E. Autism spectrum disorder scale scores in pediatric mood and anxiety disorders. J Am Acad Child Adolesc Psychiatry 2008;47(6):652- 61. [CrossRef]
11. Matsuo J, Kamio Y, Takahashi H, Ota M, Teraishi T, Hori H, et al. Autistic-like traits in adult patients with mood disorders and schizophrenia. PLoS One 2015;10(4):e0122711. [CrossRef]
12. Abu-Akel A, Clark J, Perry A, Wood SJ, Forty L, Craddock N, et al. Autistic and schizotypal traits and global functioning in bipolar I disorder. J Affect Disord 2017;207:268-75. [CrossRef]
13. American Psychiatric Association. Diagnostic and ststistical manual of mental disorders. 5th ed. Washington, DC: Author; 2013.
14. Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979;134:382-9. [CrossRef]
15. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978;133:429-35. [CrossRef]
16. Baron-Cohen S, Whellwright S, Skinner R, Martin J, Clubley E. The Autism-Spectrum Quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. J Autism Dev Disord 2001;31(5):5-17. [CrossRef]
17. Hawley CJ, Gale TM, Sivakumaran T. Hertfordshire Neuroscience Research group. Defining remission by cut off score on the MADRS: selecting the optimal value. J Affect Disord 2002;72(2):177-84. [CrossRef]
18. Ozer SK, Demir B, Tugal O, Kabakci E, Yazici MK. Montgomery and Asberg Depression Rating Scale: inter-rater reliability and validity study. Turk Psikiyatri Derg 2001;12(3):185-94. (Turkish)
19. Karadag F, Oral ET, Yalcin FA, Erten E. Reliability and validity of Turkish translation of Young Mania Rating Scale. Turk Psikiyatri Derg 2001;13(2):107-14. (Turkish)
20. Kose S, Bora E, Erermis S, Aydin C. Psychometric features of Turkish version of Autism-Spectrum Quotient. Anadolu Psikiyatri Dergisi 2010;11(3):253-60. (Turkish)
21. IBM Corp. Released 2013. IBM SPSS Statistics for Windows, Version 22.0. Armonk, NY: IBM Corp, 2013.
22. Angst J. The emerging epidemiology of hypomania and bipolar II disorder. J Affect Disord 1998;50(2-3):143-51. [CrossRef]
23. Grant BF, Stinson FS, Hasin DS, Dawson DA, Chou SP, Ruan WJ, et al. Prevalence, correlates, and comorbidity of bipolar I disorder and axis I and II disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry 2005;66(10):1205-15. [CrossRef]
24. Kupka RW, Nolen WA, Altshuler LL, Denicoff KD, Frye MA, Leverich GS, et al. The Stanley Foundation Bipolar Network. 2. Preliminary summary of demographics, course of illness and response to novel treatments. Br J Psychiatry Suppl 2001;41:S177-S83. [CrossRef]
25. Akkaya C, Altin M, Kora K, Karamustafalioglu N, Yasan A, Tomruk N, et al. Sociodemographic and clinical features of patients with bipolar I disorder in Turkey-Home study. Klinik Psikofarmakol Bülteni-Bulletin of Clinical Psychopharmacology 2012;22(1):31-42. (Turkish) [CrossRef]
26. Akarsu S, Erdem M, Bolu A, Günay H, Garip B, Ak M, et al. Bipolar bozuklukta cinsiyete göre klinik ve sosyodemografik özelliklerin karşılaştırılması. Gülhane Tıp Dergisi 2012;54(4):279-83. (Turkish) [CrossRef]
27. Ozdemir O, Coskun S, Mutlu EA, Ozdemir PG, Atli A, Yilmaz E, et al. Family history in patients with bipolar disorder. Noro Psikiyatr Ars 2016;53(3):276-9. [CrossRef]
28. Lai MC, Lombardo MV, Pasco G, Ruigrok AN, Wheelwright SJ, Sadek, SA, et al. A behavioral comparison of male and female adults with high functioning autism spectrum conditions. PloS One 2011;6(6):e20835. [CrossRef]
29. Billstedt E, Gillberg IC, Gillberg C. Autism after adolescence: population-based 13- to 22-year follow-up study of 120 individuals with autism diagnosed in childhood. J Autism Dev Disord 2005;35(3):351-60. [CrossRef]
30. Cederlund M, Hagberg B, Billstedt E, Gillberg IC, Gillberg C. Asperger syndrome and autism: a comparative longitudinal follow-up study more than 5 years after original diagnosis. J Autism Dev Disord 2008;38(1):72-85. [CrossRef]
31. Farley MA, McMahon WM, Fombonne E, Jenson WR, Miller J, Garner M, et al. Twenty-year outcome dor individuals with autism and average or near-average cognitive abilities. Autism Res 2009;2(2):109-18. [CrossRef]
32. Gotham K, Pickles A, Lord C. Trajectories of autism severity in children using standardized ADOS scores. Pediatrics 2012; 130(5),e1278-e1284. [CrossRef]
33. Tincani M, Travers J, Boutot A. Race, culture, and autism spectrum disorder: understanding the role of diversity in successful educational interventions. Res Pract Persons Severe Disabl 2009;34(3-4):81-90. [CrossRef]
34. Head AM, McGillivray JA, Stokes MA. Gender differences in emotionality and sociability in children with autism spectrum disorders. Mol Autism 2014; 5(1):19. [CrossRef]
35. Stoddart KP, Burke L, Muskat B, Manett J, Duhaime S, Accardi C, et al. Diversity in Ontario’s youth and adults with autism spectrum disorders: complex needs in unprepared systems. Toronto (ON): The Redpath Centre, 2013.
36. Simoneau TL, Miklowitz DJ, Richards JA, Saleem R, George EL. Bipolar disorder and family communication: effects of a psychoeducational treatment program. J Abnorm Psychol 1999;108(4):588-97. [CrossRef]

APA	YILDIZ M, Yorguner N, Oran demir M, Batmaz S, Çelikbaş Z, ergün s (2018). Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder. , 71 - 78. 10.5455/PBS.20180626100402
Chicago	YILDIZ Mesut,Yorguner Nese,Oran demir Meral,Batmaz Sedat,Çelikbaş Zekiye,ergün serhat Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder. (2018): 71 - 78. 10.5455/PBS.20180626100402
MLA	YILDIZ Mesut,Yorguner Nese,Oran demir Meral,Batmaz Sedat,Çelikbaş Zekiye,ergün serhat Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder. , 2018, ss.71 - 78. 10.5455/PBS.20180626100402
AMA	YILDIZ M,Yorguner N,Oran demir M,Batmaz S,Çelikbaş Z,ergün s Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder. . 2018; 71 - 78. 10.5455/PBS.20180626100402
Vancouver	YILDIZ M,Yorguner N,Oran demir M,Batmaz S,Çelikbaş Z,ergün s Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder. . 2018; 71 - 78. 10.5455/PBS.20180626100402
IEEE	YILDIZ M,Yorguner N,Oran demir M,Batmaz S,Çelikbaş Z,ergün s "Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder." , ss.71 - 78, 2018. 10.5455/PBS.20180626100402
ISNAD	YILDIZ, Mesut vd. "Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder". (2018), 71-78. https://doi.org/10.5455/PBS.20180626100402

APA	YILDIZ M, Yorguner N, Oran demir M, Batmaz S, Çelikbaş Z, ergün s (2018). Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder. Psychiatry and behavioral sciences (Online), 8(2), 71 - 78. 10.5455/PBS.20180626100402
Chicago	YILDIZ Mesut,Yorguner Nese,Oran demir Meral,Batmaz Sedat,Çelikbaş Zekiye,ergün serhat Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder. Psychiatry and behavioral sciences (Online) 8, no.2 (2018): 71 - 78. 10.5455/PBS.20180626100402
MLA	YILDIZ Mesut,Yorguner Nese,Oran demir Meral,Batmaz Sedat,Çelikbaş Zekiye,ergün serhat Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder. Psychiatry and behavioral sciences (Online), vol.8, no.2, 2018, ss.71 - 78. 10.5455/PBS.20180626100402
AMA	YILDIZ M,Yorguner N,Oran demir M,Batmaz S,Çelikbaş Z,ergün s Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder. Psychiatry and behavioral sciences (Online). 2018; 8(2): 71 - 78. 10.5455/PBS.20180626100402
Vancouver	YILDIZ M,Yorguner N,Oran demir M,Batmaz S,Çelikbaş Z,ergün s Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder. Psychiatry and behavioral sciences (Online). 2018; 8(2): 71 - 78. 10.5455/PBS.20180626100402
IEEE	YILDIZ M,Yorguner N,Oran demir M,Batmaz S,Çelikbaş Z,ergün s "Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder." Psychiatry and behavioral sciences (Online), 8, ss.71 - 78, 2018. 10.5455/PBS.20180626100402
ISNAD	YILDIZ, Mesut vd. "Correlation of Autistic Symptoms With Depression and Mania Severity in Bipolar Disorder". Psychiatry and behavioral sciences (Online) 8/2 (2018), 71-78. https://doi.org/10.5455/PBS.20180626100402