World wide liver toxicity is the most prevelent healthcare problem. We need to address this with herbal based medicine because herbal products have high efficacy and less side effects. Many of the Ehretia genus (Boraginaceae) have the hepatoprotective property. But Ehretia microphylla (EM) was not reported yet for its hepaptoprotective potential. Therefore the current research was aimed to evaluate the hepatoprotective action of EM. The hepatoprotective activity of EM was assessed against the paracetamol induced liver toxic rats. The chloroform and ethyl acetate extracts of EM were selected for the investigation. The dose was selected by using OECD423 guidelines. The paracetamol intoxicated rats were elevated the liver functional parameters like serum SGOT, SGPT and ALP levels and also triglyceride and total cholesterol. These elevated parameters were significantly lowered in chloroform and ethyl acetate extracts of EM pretreated rats when compared with silymarin. However the antioxidant markers including CAT, SOD, GSH and GPx were significantly increased in EM extract treated rats when compared with paracetamol induced toxic rats. It revealed the plant extracts of EM has significant hepatoprotective activity. Further, this research will useful for the isolation of active principles from EM and determining its molecular mechanisms.