Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study

Duran, Selcen; Uçar, Cahit; GÜÇLÜ, KENAN; YÜCEL, HASAN ESAT; Konar, Naime Meric

doi:10.46332/aemj.836358

Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study

Hasan Esat YÜCEL, (Ahi Evran Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Kırşehir, Türkiye)

Kenan GUCLU, (Araştırma ve Eğitim Hastanesi, Biyokimya Anabilim Dalı, Kırşehir, Türkiye)

Cahit UÇAR, (Ahi Evran Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Kırşehir, Türkiye)

Selcen DURAN, (Ahi Evran Üniversitesi, Tıp Fakültesi, Nöroloji Anabilim Dalı, Kırşehir, Türkiye)

Naime Meriç KONAR (Ahi Evran Üniversitesi, Tıp Fakültesi, Biyoistatistik ve Tıp Bilimleri Anabilim Dalı, Kırşehir, Türkiye)

Ahi Evran Medical Journal

4 1

Yıl: 2021 Cilt: 5 Sayı: 2 Sayfa Aralığı: 134 - 139 Metin Dili: İngilizce DOI: 10.46332/aemj.836358 İndeks Tarihi: 29-07-2022

Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study

Öz:

Purpose: Wet cupping treatment is one of the oldest known methods of treatment. Recently, some studies have shown that wet cuppingtherapy removes oxidants and reduces oxidative stres. However, these studies are limited. The aim of this study is to investigate theeffectiveness of wet cupping treatment on oxidant-anti oxidant system.Materials And Methods: Our study consisted of 26 patients. Right before the wet cupping treatment, venous blood samples werecollected. During the procedure, samples were collected from the cup blood. Right after the wet cupping treatment venous bloodsamples were collected again. On the 14th day, the participants were called and venous blood samples were collected. In all of thesesamples, total oxidant level (TOS), oxidative stress index (OSI) and total antioxidant level (TAS) levels were studied and compared.Results: Total anti-oxidant level, total oxidant level and oxidative stress index levels in cup blood were higher than all venous bloodsamples. While there was no significant change in TAS and TOS levels after the application, oxidative stress index levels decreasedsignificantly.Conclusion: Wet cupping therapy reduces the oxidative stress index, which is the most important indicator of oxidative tissue damage.Therefore, it may be involved in the treatment of diseases associated with oculatory tissue damage.

Anahtar Kelime: wet cupping treatment total oxidant level total anti-oxidant level oxidative stress ındex

Islak Kupa Tedavisinin Oksidatif Stres İndeksi ve Total Anti Oksidan Kapasite Düzeylerine Etkisinin Araştırılması: Pilot Bir Çalışma

Öz:

Amaç: Islak kupa tedavisi bilinen en eski tedavi yöntemlerinden biridir. Son zamanlarda oksidanları uzaklaştırarak, oksidatif stresi azalttığına dair bazı çalışmalar yapılmıştır. Ancak bu çalışmalar sınırlı sayıdadır. Amacımız ıslak kupa tedavisinin oksidan ve antioksidan sistem üzerindeki etkinliğini araştırmaktır. Araçlar ve Yöntem: Çalışmamıza 26 hasta dahil edildi. Islak kupa tedavisinde hemen önce venöz kan örneklemesi yapıldı. Kupa tedavisiyle birlikte kupaya dolan kandan, işlemden hemen sonra ve 14. günde yine venöz kandan örneklemeleri yapıldı. Tüm örneklerden total oksidan düzey, total anti-oksidan düzey ve oksidatif stress indeksi düzeyleri çalışılarak karşılaştırılması yapıldı. Bulgular: Kupa kanındaki total oksidan düzey, total anti-oksidan düzey ve oksidatif stres indeksi seviyeleri, tüm venöz kan parametrelerinden yüksek bulundu. Uygulama sonrası, total oksidan ve total anti-oksidan düzeylerde belirgin bir değişiklik olmazken, oksidatif stres indeksi önemli bir şekilde azalmıştır. Sonuç: Islak kupa tedavisi, oksidatif doku hasarının en önemli göstergesi olan oksidatif stres indexini azaltır. Bu nedenle oksidatif doku hasarıyla ilişkili hastalıkların tedavisinde yer alabilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Ullah K, Younis A, Wali M. An investigation into the effect of Cupping Therapy as a treatment for Anterior Knee Pain and its potential role in Health Promotion. Internet J. Altern Med. 2007;4(1):1‐9.
2. Michalsen A, Bock S, Lüdtke R, et al. Effects of Traditional Cupping Therapy in Patients With Carpal Tunnel Syndrome: A Randomized Controlled Trial. J. Pain. 2009;10(6):601‐608.
3. Eisenberg DM, Davis RB, Ettner SL, et al. Trends in Alternative Medicine Use in the United States, 1990‐ 1997: Results of a Follow‐up National Survey. JAMA 1998;280(18):1569‐1575.
4. Christopoulou‐Aletra H, Papavramidou N. Cupping: an alternative surgical procedure used by Hippocratic physicians. J Altern Complement Med. 2008;14(8):899‐902
5. Kim T, Kang JW, Kim KH, et al. Cupping for Treating Neck Pain in Video Display Terminal (VDT) Users: A Randomized Controlled Pilot Trial. J Occup. Health. 2012;54(6):416‐426.
6. Yoo SS, Tausk F. Cupping: East meets West. Int J Dermatol. 2004;43(9):664-665.
7. Ersoy S, İnci H, Sunay D, et al. Wet Cupping Therapy Improves Health Related Quality of Life: A Self‐Controlled Interventional Study. Ankara Med J. 2019;(1):270‐277.
8. Karabulut AR. Tıbb-ı Nebevî Ansiklopedisi 1-2, 6. baskı. Ankara: Kozan Ofset; 2006.
9. Zhang SJ, Liu JP, He KQ. Treament of acute gouty ar thritis by bloodletting cupping plus herbal medicine. J Tradit Chin Med. 2010;30(1):18‐20.
10. Ahmedi M, Siddiqui MR. The value of wet cupping as a therapy in modern medicineAn Islamic Perspective. Webmed Central Alternative Medicine. 2014;5(12):WMC004785.
11. Cao H, Li X, Liu J. An updated review of the efficacy of cuping theapy. PloS one 2012;7(2):e31793.
12. El Sayed SM, Mahmoud HS, Nabo MMH. Medical and scientific bases of Wet Cupping Therapy (Al-Hijamah): In Light of Modern Medicine and Prophetic Medicine. AlternInteg Med. 2013;2:1–16.
13. El Sayed SM, Al-Quliti A-S, Salah Mahmoud H,et al. Therapeutic Benefits of Al-hijamah: in Light of Modern Medicine and Prophetic Medicine. American Journal of Medical and Biological Research. 2014;2(2):46–71.
14. Kaki A, Sawsan R, Samiha M, et al. Wet Cupping Reduces Pain and Improves Health-related Quality of Life Among Patients with Migraine: A Prospective Observational Study. Oman Med J. 2019;34(2):105- 109.
15. Kavadar G, Eroğlu Demir S, Aytekin E, Akbal Y. Use of traditional and complementary medicine for musculoskeletal diseases. Turk J Med Sci. 2019- 18;49(3):809-814.
16. El-Shanshory M, Hablas NM, Shebl Y, et al. Al-hijamah (wet cupping therapy of prophetic medicine) significantly and safely reduces iron overload and oxidative stress in thalassemic children: a novel pilot study. J Blood Med. 2018; 9:241–251.
17. Tagil SM, Celik HT, Ciftci S. et al. Wet-cupping removes oxidants and decreases oxidative stress. Complementary Ther Med. 2014;22(6):1032–1036.
18. Urso ML, Clarkson, PM. Oxidative stress, exercise, and antioxidant supplementation, Toxicology. 2003;189(1-2):41-54.
19. Clarkson PM,Thompson HS. Antioxidants: What role do they play in physical activity and health?. Am J Clin Nutr. 2000;72(2):637-646.
20. Yeum KJ, Russell MR, Krinsky IN, Adlini G. Biomarkers of antioxidan capacity in hydrophilic and lipophilic compartments of human plasma. Arch Biochem Biophys. 2004;430(1):97-103.
21. Kisaoglu A, Borekci B, Yapca OE, Bilen H, Suleyman H. Tissue Damage and Oxidant/Antioxidant Balance. EAJM. 2013;45(1):47-49.
22. Goulart M, Batoreu MC, Rodrigues AS, Laires A, Rueff J. Lipoperoxidation products and thiol antioxidants in chromium exposed workers. Mutagenesis. 2005;20(5):311-315.
23. Yuliani S, Mustofa, Partadiredja G.The neuroprotective effects of an ethanolic turmeric (Curcuma longa L.) extract against trimethyltin-induced oxidative stress in rats. Nutr Neurosci. 2018;7:1-8.
24. Dai DF, Chiao YA, Marcinek DJ, Szeto HH, Rabinovitchet PS. Mitochondrial oxidative stress in aging and healthspan. Longevity Healthspan. 2014;3(1):6.
25. Mei Y, Thompson MD, Cohen RA, Tong XY. Autophagy and oxidative stress in cardiovascular diseases. Biochim Biophys Acta. 2015;1852(2):243-251.
26. Erdamar H, Demirci H, Yaman H, et al. The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status. Clin Chem Lab Med. 2008;46(7):1004-1010.
27. Weinberg F, Chandel NS. Reactive oxygen species-dependent signaling regulates cancer. Cell Mol Life Sci. 2009;66(23):3663-3673.
28. Kamat PK, Kalani A, Kyles P, Tyagi SC, Tyagi N. Autophagy of mitochondria: a promising therapeutic target for neurodegenerative disease. Cell Biochem Biophys. 2014;70(2):707-719.
29. Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem. 2004;37(4):277–285.
30. Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 2005;38(12):1103-1111.
31. Ersoy S, Altinoz E, Benli AR, et al. Investigation of wet cupping therapy’s effect on oxidative stress based on biochemical parameters. Eur J Integr Med. 2019;30:100946.

APA	YÜCEL H, GÜÇLÜ K, Uçar C, Duran S, Konar N (2021). Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study. , 134 - 139. 10.46332/aemj.836358
Chicago	YÜCEL HASAN ESAT,GÜÇLÜ KENAN,Uçar Cahit,Duran Selcen,Konar Naime Meric Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study. (2021): 134 - 139. 10.46332/aemj.836358
MLA	YÜCEL HASAN ESAT,GÜÇLÜ KENAN,Uçar Cahit,Duran Selcen,Konar Naime Meric Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study. , 2021, ss.134 - 139. 10.46332/aemj.836358
AMA	YÜCEL H,GÜÇLÜ K,Uçar C,Duran S,Konar N Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study. . 2021; 134 - 139. 10.46332/aemj.836358
Vancouver	YÜCEL H,GÜÇLÜ K,Uçar C,Duran S,Konar N Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study. . 2021; 134 - 139. 10.46332/aemj.836358
IEEE	YÜCEL H,GÜÇLÜ K,Uçar C,Duran S,Konar N "Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study." , ss.134 - 139, 2021. 10.46332/aemj.836358
ISNAD	YÜCEL, HASAN ESAT vd. "Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study". (2021), 134-139. https://doi.org/10.46332/aemj.836358

APA	YÜCEL H, GÜÇLÜ K, Uçar C, Duran S, Konar N (2021). Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study. Ahi Evran Medical Journal, 5(2), 134 - 139. 10.46332/aemj.836358
Chicago	YÜCEL HASAN ESAT,GÜÇLÜ KENAN,Uçar Cahit,Duran Selcen,Konar Naime Meric Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study. Ahi Evran Medical Journal 5, no.2 (2021): 134 - 139. 10.46332/aemj.836358
MLA	YÜCEL HASAN ESAT,GÜÇLÜ KENAN,Uçar Cahit,Duran Selcen,Konar Naime Meric Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study. Ahi Evran Medical Journal, vol.5, no.2, 2021, ss.134 - 139. 10.46332/aemj.836358
AMA	YÜCEL H,GÜÇLÜ K,Uçar C,Duran S,Konar N Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study. Ahi Evran Medical Journal. 2021; 5(2): 134 - 139. 10.46332/aemj.836358
Vancouver	YÜCEL H,GÜÇLÜ K,Uçar C,Duran S,Konar N Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study. Ahi Evran Medical Journal. 2021; 5(2): 134 - 139. 10.46332/aemj.836358
IEEE	YÜCEL H,GÜÇLÜ K,Uçar C,Duran S,Konar N "Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study." Ahi Evran Medical Journal, 5, ss.134 - 139, 2021. 10.46332/aemj.836358
ISNAD	YÜCEL, HASAN ESAT vd. "Study on the Effect of Wet Cupping Therapy on Oxidative Stres Index and Total Antioxidant Capacity Levels: A Pilot Study". Ahi Evran Medical Journal 5/2 (2021), 134-139. https://doi.org/10.46332/aemj.836358